Results 231 to 240 of about 310,786 (327)

IMMU-50. SYSTEMIC ADOPTIVE TRANSFER IMMUNOTHERAPY WITH TCR-TRANSDUCED T-CELLS TARGETING NY-ESO-1 FOR MENINGIOMA [PDF]

, 2019
Matthew Z. Sun, Joey Orpilla, Erick Contreras, Janet Treger, Donna Molaie, Jonathan Tsang, Joseph Antonios, Anthony Wang, Linda M. Liau, Robert M. Prins, Richard G. Everson   +10 more
openalex   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy

, 2016
Nicholas Casey, Hiroshi Fujiwara, Kazushi Tanimoto, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa   +7 more
openalex   +2 more sources

Requirement of Innate Immunity in Tumor-Bearing Mice Cured by Adoptive Immunotherapy Using Tumor-Draining Lymph Nodes [PDF]

, 2015
John B. Ammori, Khaled Hamzeh, Hallie J. Graor, Julian Kim   +3 more
openalex   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

An inducible caspase 9 safety switch for T-cell therapy [PDF]

, 2005
Brenner, MK, Dotti, G, Heslop, HE, Pule, MA, Rooney, CM, Spencer, DM, Straathof, KC, Vanin, EF, Yotnda, P   +8 more
core   +1 more source

Code for the publication "CERTOMICS: Trusted Single-Cell Multiomics Pipeline for High-Resolution Proling of Adoptive Cellular Immunotherapies"

Christina Katharina Kuhn
openalex   +1 more source

Tumor-Induced L-Selectinhigh Suppressor T Cells Mediate Potent Effector T Cell Blockade and Cause Failure of Otherwise Curative Adoptive Immunotherapy [PDF]

, 2002
Liaomin Peng, Jørgen Kjaergäard, Gregory E. Plautz, Mohamed K. Awad, Judith Drazba, Suyu Shu, Peter A. Cohen   +6 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Fully automated expansion and activation of clinical-grade natural killer cells for adoptive immunotherapy [PDF]

, 2015
Markus Granzin, Stephanie Soltenborn, Sabine Müller, Jutta Kollet, Maria Berg, Adelheid Cerwenka, Richard Childs, Volker Huppert   +7 more
openalex   +1 more source