Results 41 to 50 of about 214,380 (250)

Ex vivo expansion of human T cells for adoptive immunotherapy using the novel Xeno-free CTS Immune Cell Serum Replacement [PDF]

, 2015
The manufacture of clinical grade cellular products for adoptive immunotherapy requires ex vivo culture and expansion of human T cells. One of the key components in manufacturing of T cell therapies is human serum (HS) or fetal bovine serum (FBS), which ...
Schjetne, Karoline W., Lee, Sau K., Smith, Corey, Rehan, Sweera, Beagley, Leone, Aarvak, Tanja, Khanna, Rajiv, Okern, Grethe   +7 more
core   +1 more source

Autotransplantation of T-lymphocytes as a tool for antigen-specific immunotherapy of oncological diseases

Вестник трансплантологии и искусственных органов, 2018
Autotransplantation of immune cells to induce immunological rejection of tumors can be a useful approach in tumor treatment. Despite the low efficiency of this  approach demonstrated in the past, the active development of cell technologies and  genetic ...
A. Yu. Lupatov, P. A. Karalkin, A. A. Boyko, K. N. Yarygin   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

Journal for ImmunoTherapy of Cancer, 2017
Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors.
Irene Scarfò, Marcela V. Maus
doaj   +1 more source

Novel Immunotherapeutic Approach in Gastric Cancer

Acta Medica Bulgarica, 2020
Gastric cancer (GC) is suitable for immunotherapy because 80% of it display microsatellite and chromosomal instability, some mutations and DNA hypermethylation. Therefore, GC is more immunogenic.
Gulubova M., Hadzhi M., Ignatova M., Chonov D., Balakan O., Aydan M., Ananiev J.   +6 more
doaj   +1 more source

Adoptive Immunotherapy beyond CAR T-Cells. [PDF]

Cancers (Basel), 2021
Adoptive cell immunotherapy (ACT) is a vibrant field of cancer treatment that began progressive development in the 1980s. One of the most prominent and promising examples is chimeric antigen receptor (CAR) T-cell immunotherapy for the treatment of B-cell
Titov A, Zmievskaya E, Ganeeva I, Valiullina A, Petukhov A, Rakhmatullina A, Miftakhova R, Fainshtein M, Rizvanov A, Bulatov E.   +9 more
europepmc   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors [PDF]

, 1988
The ability of memory T lymphocytes derived from latently infected mice to control murine cytomegalovirus disease in the immunocompromised host was studied by adoptive transfer experiments.
Reddehase, Matthias J., Koszinowski, Ulrich H., Mutter, Wolfgang, Jonjic, Stipan, Weiland, Frank   +4 more
core   +1 more source

Long-term survival after immunotherapy and targeted therapy without chemotherapy in an elderly patient with HER2-positive gastroesophageal junction cancer: A case report

Human Vaccines & Immunotherapeutics, 2022
A 74-yr-old man underwent thoracic laparoscopy combined with radical gastrectomy, and the postoperative pathological diagnosis was esophageal and gastric cardia cancer pT3N1M0, pStage IIB. Immunohistochemical staining for HER2 (3+) and PD-L1 (
Wei-Ling Li, Ying Zhang, Xiao-Ling Zhang, Yun-Yi Du, Wen-Qing Hu, Jun Zhao   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source