Results 31 to 40 of about 44,621 (163)

The State of Cellular Adoptive Immunotherapy for Neuroblastoma and Other Pediatric Solid Tumors

Frontiers in Immunology, 2017
Research on adult cancer immunotherapy is proceeding at a rapid pace resulting in an impressive success rate exemplified by a few high profile cases. However, this momentum is not readily extended to pediatric immunotherapy, and it is not for lack of ...
Thanh-Phuong Le, To-Ha Thai
doaj   +1 more source

Application of Immunotherapy in Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Hepatocellular carcinoma is one of the most common malignancies globally. It not only has a hidden onset but also progresses rapidly. Most HCC patients are already in the advanced stage of cancer when they are diagnosed, and have even lost the ...
Lele Miao, Lele Miao, Zhengchao Zhang, Zhengchao Zhang, Zhijian Ren, Zhijian Ren, Yumin Li, Yumin Li   +7 more
doaj   +1 more source

Comparative assessment of autologous and allogeneic iNKT cell transfer in iNKT cell-based immunotherapy

Frontiers in Immunology
Invariant natural killer T (iNKT) cells are a small subset of T lymphocytes that release large amounts of cytokines such as IFN-γ and exhibit cytotoxic activity upon activation, inducing strong anti-tumor effects.
Mariko Takami, Shinichiro Motohashi
doaj   +1 more source

Immunotherapeutic Strategies for Head and Neck Squamous Cell Carcinoma (HNSCC): Current Perspectives and Future Prospects

Vaccines, 2022
Neoantigens are abnormal proteins produced by genetic mutations in somatic cells. Because tumour neoantigens are expressed only in tumour cells and have immunogenicity, they may represent specific targets for precision immunotherapy.
Lei Gao, Anqi Zhang, Fuyuan Yang, Wei Du
doaj   +1 more source

Chimeric Antigen Receptor T Cell Therapy in Hematology

Turkish Journal of Hematology, 2015
It is well demonstrated that the immune system can control and eliminate cancer cells. Immune-mediated elimination of tumor cells has been discovered and is the basis of both cancer vaccines and cellular therapies including hematopoietic stem cell ...
Pınar Ataca, Önder Arslan
doaj   +1 more source

Autotransplantation of T-lymphocytes as a tool for antigen-specific immunotherapy of oncological diseases

Вестник трансплантологии и искусственных органов, 2018
Autotransplantation of immune cells to induce immunological rejection of tumors can be a useful approach in tumor treatment. Despite the low efficiency of this  approach demonstrated in the past, the active development of cell technologies and  genetic ...
A. Yu. Lupatov, P. A. Karalkin, A. A. Boyko, K. N. Yarygin   +3 more
doaj   +1 more source

Novel Immunotherapeutic Approach in Gastric Cancer

Acta Medica Bulgarica, 2020
Gastric cancer (GC) is suitable for immunotherapy because 80% of it display microsatellite and chromosomal instability, some mutations and DNA hypermethylation. Therefore, GC is more immunogenic.
Gulubova M., Hadzhi M., Ignatova M., Chonov D., Balakan O., Aydan M., Ananiev J.   +6 more
doaj   +1 more source

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

Journal for ImmunoTherapy of Cancer, 2017
Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors.
Irene Scarfò, Marcela V. Maus
doaj   +1 more source

Long-term survival after immunotherapy and targeted therapy without chemotherapy in an elderly patient with HER2-positive gastroesophageal junction cancer: A case report

Human Vaccines & Immunotherapeutics, 2022
A 74-yr-old man underwent thoracic laparoscopy combined with radical gastrectomy, and the postoperative pathological diagnosis was esophageal and gastric cardia cancer pT3N1M0, pStage IIB. Immunohistochemical staining for HER2 (3+) and PD-L1 (
Wei-Ling Li, Ying Zhang, Xiao-Ling Zhang, Yun-Yi Du, Wen-Qing Hu, Jun Zhao   +5 more
doaj   +1 more source

Adoptive Immunotherapy in Chimeras with Donor Lymphocytes [PDF]

Acta Haematologica, 2003
Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to separate the graft-versus-leukemia (GVL) effect from graft-versus-host disease (GVHD).
Kolb, Hans-Jochem, Schmid, Christoph, Chen, Xiao, Woiciechowski, Anja, Roskrow, Marie, Weber, Martin, Guenther, Wolfgang, Ledderose, Georg, Schleuning, Michael   +8 more
openaire   +4 more sources