Results 11 to 20 of about 368,892 (303)

Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer

Nature Communications, 2021
Emerging data demonstrate that the activity of immune cells can be modulated by microbial molecules. Here, we show that the short-chain fatty acids (SCFAs) pentanoate and butyrate enhance the anti-tumor activity of cytotoxic T lymphocytes (CTLs) and ...
Maik Luu, Zeno Riester, Adrian Baldrich, Nicole Reichardt, S. Yuille, A. Busetti, M. Klein, Anne Wempe, Hanna Leister, H. Raifer, F. Picard, K. Muhammad, K. Ohl, Rossana Romero, Florence Fischer, C. Bauer, M. Huber, T. Gress, M. Lauth, Sophia Danhof, T. Bopp, T. Nerreter, I. Mulder, U. Steinhoff, M. Hudecek, A. Visekruna   +25 more
semanticscholar   +1 more source

Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T

Molecular Cancer, 2023
In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T) therapy are two milestone achievements in clinical immunotherapy. However, both show limited efficacies in most solid neoplasms, which necessitates the exploration
Qiaofei Liu, Jia-Yao Li, Huaijin Zheng, Sen Yang, Yuze Hua, Nan Huang, J. Kleeff, Q. Liao, Wenming Wu   +8 more
semanticscholar   +1 more source

CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

Nature Communications, 2021
The immunosuppressive tumor microenvironment (TME) represents a major barrier for effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous and plastic cell components of the TME which can either promote tumor progression (M2 ...
A. Rodríguez-García, Rachel C. Lynn, M. Poussin, Monika A. Eiva, Lauren Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, T. Matsuyama, D. Powell   +10 more
semanticscholar   +1 more source

The Combined Clinical Efficacy and Safety Analysis of Adoptive Immunotherapy with Radiotherapy and Chemotherapy in Non-Small-Cell Lung Cancer: Systematic Review and Meta-Analysis

Applied Bionics and Biomechanics, 2022
Objective. To explore the differential efficacy of chemoradiotherapy combined with adoptive immunotherapy and radiochemotherapy alone in patients with non-small-cell lung cancer (NSCLC). Methods.
Zhiming Fan, Honggui He, Liqun Chen
doaj   +1 more source

Neoantigen‐reactive T cell: An emerging role in adoptive cellular immunotherapy

MedComm, 2021
Adoptive cellular immunotherapy harnessing the intrinsic immune system for precise treatment has exhibited preliminary success against malignant tumors.
Yicheng Zhu, Youkun Qian, Zhile Li, Yangyang Li, Bin Li   +4 more
doaj   +1 more source

Genetic ablation of PRDM1 in antitumor T cells enhances therapeutic efficacy of adoptive immunotherapy.

Blood, 2021
Adoptive cancer immunotherapy can induce objective clinical efficacy in patients with advanced cancer; however, a sustained response is achieved in a minority of cases.
T. Yoshikawa, Zhiwen Wu, Satoshi Inoue, Hitomi Kasuya, H. Matsushita, Yusuke Takahashi, H. Kuroda, W. Hosoda, Shiro Suzuki, Yuki Kagoya   +9 more
semanticscholar   +1 more source

Anti-Tumor Effects after Adoptive Transfer of IL-12 Transposon-Modified Murine Splenocytes in the OT-I-Melanoma Mouse Model. [PDF]

PLoS ONE, 2015
Adoptive transfer of gene modified T cells provides possible immunotherapy for patients with cancers refractory to other treatments. We have previously used the non-viral piggyBac transposon system to gene modify human T cells for potential immunotherapy.
Daniel L Galvan, Richard T O'Neil, Aaron E Foster, Leslie Huye, Adham Bear, Cliona M Rooney, Matthew H Wilson   +6 more
doaj   +1 more source

New Orders to an Old Soldier: Optimizing NK Cells for Adoptive Immunotherapy in Hematology [PDF]

Biomedicines, 2021
, Erden Atilla, Pinar Ataca
exaly   +2 more sources

Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Nature Biomedical Engineering, 2021
Malignant transformation and tumour progression are associated with cancer-cell softening. Yet how the biomechanics of cancer cells affects T-cell-mediated cytotoxicity and thus the outcomes of adoptive T-cell immunotherapies is unknown.
Kewen Lei, Armand Kurum, Murat Kaynak, Lucia Bonati, Y. Han, Veronika Cencen, Min Gao, Yu-Qing Xie, Yugang Guo, M. Hannebelle, Yangping Wu, Guanyu Zhou, Ming Guo, G. Fantner, M. Sakar, Li Tang   +15 more
semanticscholar   +1 more source

Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors

Hematology, Transfusion and Cell Therapy, 2021
The use of immunotherapy in cancer treatment over the past decade has resulted in significant advances and improvements in cancer patients survival with the use of checkpoint inhibitors.
Mirella Nardo, Tatiane C. Motta, Leandro M. Colli, Mauro P. Avanzi   +3 more
doaj   +1 more source