Results 301 to 310 of about 132,161 (355)
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Adoptive Transfer Immunization of Mice
Cold Spring Harbor Protocols, 2021This procedure is designed to enrich and expand antibody-forming cells for use in generating monoclonal antibodies. Gamma-irradiation is used to wipe out the immune system in a recipient animal, after which spleen cells that have reverted to memory cells are obtained from syngeneic donor animals and transferred to the irradiated animal, allowing the ...
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Adoptive cell transfer therapy for melanoma
Experimental Dermatology, 2022AbstractAdoptive cell transfer (ACT) of tumor‐infiltrating lymphocytes (TILs) for melanoma is an example of the most successful cancer immune therapy. It achieves a durable complete response about ~20% of patients, and they might be cured. However, the ratio of patients with durable benefits is not high, and its complicated procedure prevents its ...
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Adoptive T-cell Transfer in Melanoma
Immunotherapy, 2012Immunotherapy holds a highly promising treatment approach for metastatic melanoma patients. Adoptive cell transfer (ACT) involves the ex vivo expansion of autologous antitumor reactive lymphocytes and their reinfusion into lymphodepleted patients, accompanied by IL-2 administration.
Orit, Itzhaki +6 more
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Adoptive transfer of T-cell immunity
Trends in Immunology, 2002Abstract Allogeneic transplantation is the most successful form of T-cell-based cancer immunotherapy to date. However, a major complication of allogeneic transplantation remains the occurrence of graft-versus-host disease (GVHD). Two recent developments might lead to procedures for the induction of strong tumor-specific T-cell immunity without these ...
Helmut W H G, Kessels +2 more
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2019
Lymphocytes are an important component of inflammatory bowel disease (IBD) pathogenesis. T cells in particular are potent inducers of inflammation in this disease as well as recurrent players in chronic lesion formation. Here we describe a method for adoptive transfer colitis in mice, which serves as a T cell-based model of inflammatory bowel disease ...
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Lymphocytes are an important component of inflammatory bowel disease (IBD) pathogenesis. T cells in particular are potent inducers of inflammation in this disease as well as recurrent players in chronic lesion formation. Here we describe a method for adoptive transfer colitis in mice, which serves as a T cell-based model of inflammatory bowel disease ...
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Knowledge/technology transfer and adoption
Proceedings of the 33rd Annual Hawaii International Conference on System Sciences, 2005Knowledge management is comprised of knowledge generation, transfer, accumulation, adoption, and diffusion. Contemporary technology transfer (TT) focuses on the adoption of knowledge. Technology is essentially knowledge. Transfer is the movement of knowledge/technology via some type of channel (analog or digital): person-to-person, group-to-group, and ...
D.V. Gibson +2 more
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2012
The clinical use of adoptively-transferred T or NK lymphocytes with anti-tumor activity is gaining in popularity as reports of success accumulate. High specific activity with minimal off target effects contribute to a class of therapy with minimal toxicity that is transformative for cancer patients, who with their physicians have come to accept severe ...
Donald R. Shaffer +2 more
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The clinical use of adoptively-transferred T or NK lymphocytes with anti-tumor activity is gaining in popularity as reports of success accumulate. High specific activity with minimal off target effects contribute to a class of therapy with minimal toxicity that is transformative for cancer patients, who with their physicians have come to accept severe ...
Donald R. Shaffer +2 more
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Adoptive Transfer of Immunity to Plasmodium berghei
The Journal of Protozoology, 1969SYNOPSIS. Immunity to P. berghei in rats was transferred adoptively with spleen cells but not with bone marrow cells, thymus cells, peripheral lymph node cells or thoracic duct lymphocytes from immune donors. The parasite multiplies at the same rate in control and protected rats but when about 10% of host red cells are infected the number of infected ...
J A, Roberts, P, Tracey-Patte
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Adoptive transfer of immunodiabetes in guinea pig
Acta Diabetologica Latina, 1974Inoculation of lymph node or spleen cells from diabetic guinea pigs producing precipitating anti-insulin antibodies produced signs of immunodiabetes in young guinea pigs with cyclophosphamide-suppressed immunological reactivity. Blood sugar increased on day 5 after the cell transfer and distinct B-cell degranulation in the islets of Langerhans was ...
L, Korcáková, M, Titlbach, K, Nouza
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Adoptive cell transfer in autoimmune hepatitis
Expert Review of Gastroenterology & Hepatology, 2015Adoptive cell transfer is an intervention in which autologous immune cells that have been expanded ex vivo are re-introduced to mitigate a pathological process. Tregs, mesenchymal stromal cells, dendritic cells, macrophages and myeloid-derived suppressor cells have been transferred in diverse immune-mediated diseases, and Tregs have been the focus of ...
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