Results 351 to 360 of about 3,248,964 (397)
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Adoptive T‐cell transfer in cancer immunotherapy
Immunology & Cell Biology, 2006Adoptive T‐cell therapy has definite clinical benefit in relapsed leukaemia after allogeneic transplant and in Epstein–Barr virus‐associated post‐transplant lymphoproliferative disease. However, the majority of tumour targets are weakly immunogenic self‐antigens and success has been limited in part by inadequate persistence and expansion of transferred
Tey, Siok-Keen +2 more
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Adoptive Transfer of Immunity to Plasmodium berghei
The Journal of Protozoology, 1969SYNOPSIS. Immunity to P. berghei in rats was transferred adoptively with spleen cells but not with bone marrow cells, thymus cells, peripheral lymph node cells or thoracic duct lymphocytes from immune donors. The parasite multiplies at the same rate in control and protected rats but when about 10% of host red cells are infected the number of infected ...
J. A. Roberts, P. Tracey-Patte
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2012
The clinical use of adoptively-transferred T or NK lymphocytes with anti-tumor activity is gaining in popularity as reports of success accumulate. High specific activity with minimal off target effects contribute to a class of therapy with minimal toxicity that is transformative for cancer patients, who with their physicians have come to accept severe ...
Conrad Russell Y. Cruz +2 more
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The clinical use of adoptively-transferred T or NK lymphocytes with anti-tumor activity is gaining in popularity as reports of success accumulate. High specific activity with minimal off target effects contribute to a class of therapy with minimal toxicity that is transformative for cancer patients, who with their physicians have come to accept severe ...
Conrad Russell Y. Cruz +2 more
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Knowledge/technology transfer and adoption
Proceedings of the 34th Annual Hawaii International Conference on System Sciences, 2005Knowledge management is comprised of knowledge generation, transfer, accumulation, adoption, and diffusion. Contemporary technology transfer (TT) focuses on the adoption of knowledge. Technology is essentially knowledge. Transfer is the movement of knowledge/technology via some type of channel (analog or digital): person-to-person, group-to-group, and ...
David V. Gibson +2 more
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Transiently redirected T cells for adoptive transfer
Cytotherapy, 2011T cells can be redirected to reject cancer by retroviral transduction with a chimeric antigen receptor (CAR) or by administration of a bispecific T cell engager (BiTE). We demonstrate that transfection of T cells with messenger (m) RNA coding for CAR is an alternative strategy.We describe the pre-clinical evaluation of a method based on transient ...
Gustav Gaudernack +8 more
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Adoptive cell transfer therapy for melanoma
Experimental Dermatology, 2022AbstractAdoptive cell transfer (ACT) of tumor‐infiltrating lymphocytes (TILs) for melanoma is an example of the most successful cancer immune therapy. It achieves a durable complete response about ~20% of patients, and they might be cured. However, the ratio of patients with durable benefits is not high, and its complicated procedure prevents its ...
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Transfer And Adoption Of Labour Saving Technologies
Journal of Research in National Development, 2008The study was carried out to assess the transfer and adoption of labour saving technologies in Apa Local Government area of BenueState. A total sample size One Hundred and Twenty was used in the study. Interview schedule was used to collect the data from respondents.
EE Idu, GO Ogwola
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1984
Publisher Summary This chapter describes adoptive transfer as the transfer of immunity from one animal to another by live, immunocompetent cells as opposed to immune serum or preformed antibody. It explores that the principle of adoptive transfer showed delayed-type hypersensitivity to picryl chloride could be transferred from sensitized to normal ...
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Publisher Summary This chapter describes adoptive transfer as the transfer of immunity from one animal to another by live, immunocompetent cells as opposed to immune serum or preformed antibody. It explores that the principle of adoptive transfer showed delayed-type hypersensitivity to picryl chloride could be transferred from sensitized to normal ...
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Isolation of Immune Cells for Adoptive Transfer
2017Adoptive transfer of T lymphocytes is a useful technique to characterize the role of the immune system in hypertension and vascular disease. Here we describe as an example the isolation of splenic T regulatory cells from donor mice processed to obtain a single cell suspension, followed by negative and positive selection to obtain CD4+ T cells and CD4 ...
Ernesto L. Schiffrin +3 more
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Adoptive Transfer of Splenocytes to Immunocompromised Mice
2012Analysis of the immune response of mice to Helicobacter infection has been greatly aided by the use of various deficient mouse strains. Here we present protocols for reconstitution of immune-deficient mice with wild-type immune cells and protocols for analysis of the outcome.
Kathryn A. Eaton, Brian M. Gray
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