Results 231 to 240 of about 81,958 (262)

ADP-Ribose in Glycation and Glycoxidation Reactions

1997
Glycation is initiated by reaction of a reducing sugar with a protein amino group to generate a Schiff base adduct. Following an Amadori rearrangement to form a ketoamine adduct, a complex chemistry involving oxidation often leads to protein glycoxidation products referred to as advanced glycosylation end products (AGE).
E L, Jacobson, D, Cervantes-Laurean, M K, Jacobson   +2 more
openaire   +2 more sources

Detection of poly(ADP-ribose) polymerase and its reaction product poly(ADP-ribose) by immunocytochemistry

The Histochemical Journal, 1996
Poly(ADP-ribose) polymerase catalyses the formation of ADP-ribose polymers covalently attached to various nuclear proteins, using NAD+ as substrate. The activity of this enzyme is strongly stimulated upon binding to DNA single or double strand breaks. Poly(ADP-ribosyl)ation is an immediate cellular response to DNA damage and is thought to be involved ...
J H, Küpper, L, van Gool, M, Müller, A, Bürkle   +3 more
openaire   +2 more sources

New Insights into the Roles of NAD+-Poly(ADP-ribose) Metabolism and Poly(ADP-ribose) Glycohydrolase

Current Protein & Peptide Science, 2016
Accumulating evidence has suggested the fundamental functions of NAD+-poly(ADP-ribose) metabolism in cellular and physiological processes, including energy homeostasis, signal transduction, DNA transaction, genomic stability and cell death or survival. The NAD+ biosynthesis and poly(ADP-ribose) [(ADP-R)n] turnover are tightly controlled by several key ...
Seiichi, Tanuma, Akira, Sato, Takahiro, Oyama, Atsushi, Yoshimori, Hideaki, Abe, Fumiaki, Uchiumi   +5 more
openaire   +2 more sources

Monoclonal Antibodies against Poly(ADP-ribose) Recognize Different Structures of Poly(ADP-ribose)

2020
The characteristics of two monoclonal antibodies to poly(ADP-Rib) and the various structures of poly(ADP-Rib) recognized by these monoclonal antibodies have been examined. One antibody, IgG monoclonal antibody 10H, reacted with most parts of poly (ADP-Rib) molecules, and its binding was only slightly inhibited by Ado(P)-Rib-P, a monomer unit of the ...
H, Kawamitsu, H, Hoshino, M, Miwa, T, Sugimura   +3 more
openaire   +2 more sources

Quantification of Poly(ADP-Ribose) In Vitro: Determination of the ADP-Ribose Chain Length and Branching Pattern

2011
The structural integrity of eukaryotic genomes, to a great extent, depends on highly regulated and -coordinated enzymatic chromosomal poly(ADP-ribosyl)ation cycles that target chromatin proteins for specific covalent epigenetic poly(ADP-ribose) modification.
Rafael, Alvarez-Gonzalez, Myron K, Jacobson   +1 more
openaire   +2 more sources

The rise of ADP-ribose–ubiquitin

Nature Structural & Molecular Biology
Chatrin Chatrin, Kang Zhu, Ivan Ahel
openaire   +2 more sources

Poly(ADP-ribose): A Dynamic Trigger for Biomolecular Condensate Formation

Trends in Cell Biology, 2020
Anthony K L Leung
exaly  

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

Ca-A Cancer Journal for Clinicians, 2011
Johann S de Bono, Timothy A Yap, Shahneen Sandhu   +2 more
exaly  

Poly(ADP-ribose) (PAR) polymer is a death signal

Proceedings of the National Academy of Sciences of the United States of America, 2006
Valina Dawson, Shaida Andrabi, Guy Poirier   +2 more
exaly  

ADP-Ribose

1997
openaire   +1 more source