Results 261 to 270 of about 133,679 (301)
Some of the next articles are maybe not open access.
The Use of Biotinylated Poly(ADP-Ribose) for Studies on Poly(ADP-Ribose)-Protein Interaction
Analytical Biochemistry, 1994Poly(ADP-ribose) is routinely detected by the use of radioactive polymers formed from labeled substrates. In this report a simple and time-saving method for the biotinylation and the detection of poly(ADP-ribose) on blots is described. The polymer modified by light-induced reaction with photobiotin was colorimetrically detected and quantified, using ...
F M, Narendja, G, Sauermann
openaire +2 more sources
Poly(ADP-ribose): Historical perspective
Molecular and Cellular Biochemistry, 1994The early historical background of the discovery of poly(ADP-ribose) and the following development of science on poly(ADP-ribose) are reviewed. Fundamental knowledge on the natures of poly(ADP-ribose), poly(ADP-ribose) polymerase and enzymes degrading poly(ADP-ribose) are summarized with brief description on the methodology for their purification and ...
Masanao Miwa
exaly +3 more sources
Journal of Molecular Graphics and Modelling, 2013
Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme responsible for the degradation of ADP-ribose polymers. Very recently, the first crystal structure of PARG was reported (Dea Slade, et al., Nature 477 (2011) 616), and a possible SN1-type-like mechanism was proposed.
Qianqian, Hou +4 more
openaire +2 more sources
Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme responsible for the degradation of ADP-ribose polymers. Very recently, the first crystal structure of PARG was reported (Dea Slade, et al., Nature 477 (2011) 616), and a possible SN1-type-like mechanism was proposed.
Qianqian, Hou +4 more
openaire +2 more sources
Trapping Poly(ADP-Ribose) Polymerase
The Journal of Pharmacology and Experimental Therapeutics, 2015Recent findings indicate that a major mechanism by which poly(ADP-ribose) polymerase (PARP) inhibitors kill cancer cells is by trapping PARP1 and PARP2 to the sites of DNA damage. The PARP enzyme-inhibitor complex "locks" onto damaged DNA and prevents DNA repair, replication, and transcription, leading to cell death.
Yuqiao, Shen +2 more
openaire +2 more sources
The Life History of Poly(ADP-ribose)
2020We present arguments and data in support of the following sequence of events in ghost cells. Poly(ADP-ribose, ADPR) synthetase, activated by binding to DNA at a break or other anomaly, synthesizes chains of polymer upon itself, adding new residues at the proximal 1" terminus of the growing chain.
M, Ikejima +4 more
openaire +2 more sources
Preparation of cyclic ADP-ribose antagonists and caged cyclic ADP-ribose.
Methods in enzymology, 1997link_to_subscribed_fulltext
Gee, KR +6 more
openaire +3 more sources
The crystal structure of cyclic ADP-ribose
Nature Structural Biology, 1994link_to_subscribed_fulltext
Aarhus, R, Lee, HC, Levitt, D
openaire +4 more sources
Position of Cyclization in Cyclic ADP-Ribose
Biochemical and Biophysical Research Communications, 1993Cyclic adenosine diphosphoribose (cADPR) is a putative second messenger of calcium homeostasis synthesized from NAD by cleavage of the nicotinamide-ribose bond and cyclization of the ribose to the adenine ring. In this study, the ultraviolet absorption spectra of cADPR have been studied as a function of pH and compared to other compounds containing an ...
H, Kim, E L, Jacobson, M K, Jacobson
openaire +2 more sources
Poly(ADP-Ribose) Polymerase Inhibitors
Current Medicinal Chemistry, 2003Poly(ADP-ribose) polymerase-1 (PARP-1) is the principal member of the PARP enzyme family consisting of PARP-1 and several recently identified novel poly(ADP-ribosyl)ating enzymes. PARP-1 functions as a DNA damage sensor and signalling molecule. Upon binding to DNA breaks, activated PARP cleaves NAD(+) into nicotinamide and ADP-ribose and polymerizes ...
Garry J, Southan, Csaba, Szabó
openaire +2 more sources
Enzymology of ADP-ribose polymer synthesis
Molecular and Cellular Biochemistry, 1994In this minireview, we summarize recent advances on the enzymology of ADP-ribose polymer synthesis. First, a short discussion of the primary structure and cloning of poly(ADP-ribose) polymerase (PARP) [EC 2.4.2.30], the enzyme that catalyzes the synthesis of poly(ADP-ribose), is presented.
R, Alvarez-Gonzalez +2 more
openaire +2 more sources