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Poly(ADP-ribose) signaling in cell death
Molecular Aspects of Medicine, 2013Poly(ADP-ribosyl)ation (PARylation) is a reversible protein modification carried out by the concerted actions of poly(ADP-ribose) polymerase (PARP) enzymes and poly(ADP-ribose) (PAR) decomposing enzymes such as PAR glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3).
László Virág +2 more
exaly +4 more sources
The Histochemical Journal, 1996
Poly(ADP-ribose) polymerase catalyses the formation of ADP-ribose polymers covalently attached to various nuclear proteins, using NAD+ as substrate. The activity of this enzyme is strongly stimulated upon binding to DNA single or double strand breaks. Poly(ADP-ribosyl)ation is an immediate cellular response to DNA damage and is thought to be involved ...
J H, Küpper +3 more
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Poly(ADP-ribose) polymerase catalyses the formation of ADP-ribose polymers covalently attached to various nuclear proteins, using NAD+ as substrate. The activity of this enzyme is strongly stimulated upon binding to DNA single or double strand breaks. Poly(ADP-ribosyl)ation is an immediate cellular response to DNA damage and is thought to be involved ...
J H, Küpper +3 more
openaire +2 more sources
New Insights into the Roles of NAD+-Poly(ADP-ribose) Metabolism and Poly(ADP-ribose) Glycohydrolase
Current Protein & Peptide Science, 2016Accumulating evidence has suggested the fundamental functions of NAD+-poly(ADP-ribose) metabolism in cellular and physiological processes, including energy homeostasis, signal transduction, DNA transaction, genomic stability and cell death or survival. The NAD+ biosynthesis and poly(ADP-ribose) [(ADP-R)n] turnover are tightly controlled by several key ...
Seiichi, Tanuma +5 more
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ADP-Ribose in Glycation and Glycoxidation Reactions
1997Glycation is initiated by reaction of a reducing sugar with a protein amino group to generate a Schiff base adduct. Following an Amadori rearrangement to form a ketoamine adduct, a complex chemistry involving oxidation often leads to protein glycoxidation products referred to as advanced glycosylation end products (AGE).
E L, Jacobson +2 more
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Biotin-Labeling of Poly(ADP-ribose) in Poly(ADP-ribose)-Protein Interactions
1996Methods are described for the preparation of poly(ADP-ribose) and for the preparation of biotinylated poly(ADP-ribose). Poly(ADP-ribose) is covalently modified to its biotinylated derivative by light-induced reaction of photobiotin with the polymer.
Frank M. Narendja, Georg Sauermann
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Monoclonal Antibodies against Poly(ADP-ribose) Recognize Different Structures of Poly(ADP-ribose)
2020The characteristics of two monoclonal antibodies to poly(ADP-Rib) and the various structures of poly(ADP-Rib) recognized by these monoclonal antibodies have been examined. One antibody, IgG monoclonal antibody 10H, reacted with most parts of poly (ADP-Rib) molecules, and its binding was only slightly inhibited by Ado(P)-Rib-P, a monomer unit of the ...
H, Kawamitsu +3 more
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Medicinal Chemistry and Pharmacology of Cyclic ADP‐Ribose
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Barry V L, Potter, Timothy F, Walseth
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2011
The structural integrity of eukaryotic genomes, to a great extent, depends on highly regulated and -coordinated enzymatic chromosomal poly(ADP-ribosyl)ation cycles that target chromatin proteins for specific covalent epigenetic poly(ADP-ribose) modification.
Rafael, Alvarez-Gonzalez +1 more
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The structural integrity of eukaryotic genomes, to a great extent, depends on highly regulated and -coordinated enzymatic chromosomal poly(ADP-ribosyl)ation cycles that target chromatin proteins for specific covalent epigenetic poly(ADP-ribose) modification.
Rafael, Alvarez-Gonzalez +1 more
openaire +2 more sources
1987
In eukaryotic cells, two different types of enzymes are known to attack poly-(ADP-ribose). The first enzyme, poly(ADP-ribose) glycohydrolase, cleaves ri-bose-ribose bonds of both linear and branched portions of poly(ADP-ribose) polymers by an exoglycosidic hydrolysis mode.
Felix R. Althaus, Christoph Richter
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In eukaryotic cells, two different types of enzymes are known to attack poly-(ADP-ribose). The first enzyme, poly(ADP-ribose) glycohydrolase, cleaves ri-bose-ribose bonds of both linear and branched portions of poly(ADP-ribose) polymers by an exoglycosidic hydrolysis mode.
Felix R. Althaus, Christoph Richter
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Enzymatic properties of poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase on chromatin
1992The catabolism of NAD+ in cells is carried out by poly(ADP-ribose) polymerase (PARP) which converts NAD+ into poly(ADP-ribose) in response to DNA damage. All the evidence that has accumulated up to now indicates that the degradation of poly(ADP-ribose) in vivo is carried out by poly(ADP-ribose) glycohydrolase (the glycohydrolase) and not by a ...
Hélène Thomassin +6 more
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