Results 241 to 250 of about 133,679 (301)

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age‐Dependent Structural Deficits in the Kidney

Aging Cell, Volume 25, Issue 5, May 2026.
During kidney aging, loss of the MICOS complex drives cristae disorganization, impairs oxidative capacity, and alters mitochondrial dynamics. MICOS disruption elevates mitochondrial ROS and disrupts calcium homeostasis, linking mitochondrial structural remodeling to metabolic dysfunction in aging kidney tissue.
Prasanna Katti, Praveena Prasad, Sepiso K. Masenga, Prasanna Venkhatesh, Zer Vue, Andrea G. Marshall, Benjamin Rodriguez, Han Le, Edgar Garza‐Lopez, Alexandria Murphy, Brenita Jenkins, Ashlesha Kadam, Jianqiang Shao, Amber Crabtree, Pamela Martin, Chantell Evans, Mark A. Phillips, David Hubert, Nelson Wandira, Okwute M. Ochayi, Dhanendra Tomar, Clintoria R. Williams, Jennifer Gaddy, Briar Tomeau, LaCara Bell, Taneisha Gillyard, Markis' Hamilton, Vineeta Sharma, Mohd Mabood Khan, Elma Zaganjor, Olujimi A. Ajijola, Estevão Scudese, Tyne W. Miller Fleming, André Kinder, Chandravanu Dash, Anita M. Quintana, Bret C. Mobley, Julia D. Berry, Pooja Jadiya, Dao‐Fu Dai, Annet Kirabo, Oleg Kovtun, Jenny C. Schafer, Sean Schaffer, Renata Oliveira Pereira, Debra D. Murray, Joyonna Gamble‐George, Melanie R. McReynolds, Antentor Hinton Jr   +48 more
wiley   +1 more source

Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage. [PDF]

DNA Repair (Amst)
Al-Rahahleh RQ, Roos WP, Saville KM, Andrews JF, Wu Z, Koczor CA, Prakash A, Sobol RW.   +7 more
europepmc   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Targeted Treatment of Cancer by Using Conjugate Compounds with Poly(ADP-ribose) Polymerase (PARP) Inhibitors. [PDF]

ACS Med Chem Lett
Zhou X, Liang SH.
europepmc   +1 more source

Genomic Profiling in Localized Prostate Cancer: Associations With Biochemical Recurrence and Response to Salvage Radiotherapy

Cancer Science, Volume 117, Issue 5, Page 1469-1480, May 2026.
Early screening for somatic alterations in localized prostate cancer could help predict biochemical recurrence risk and optimize salvage therapy selection. ABSTRACT The clinical significance of comprehensive genomic profiling (CGP) has been established in metastatic castration‐resistant prostate cancer (PC).
Kenji Zennami, Tetsuya Takimoto, Takuhisa Nukaya, Makoto Sumitomo, Mayu Takeda, Eiji Sugihara, Hideyuki Saya, Ryoichi Shiroki   +7 more
wiley   +1 more source

Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition. [PDF]

J Phys Chem B
Shanmugam N, Chatterjee S, Cisneros GA.
europepmc   +1 more source

Development and characterization of recombinant ADP-ribose binding reagents that allow simultaneous detection of mono and poly ADP-ribose. [PDF]

J Biol Chem
Chiu SP, Camacho CV, Kraus WL.
europepmc   +1 more source

Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose. [PDF]

EMBO J
Bejan DS, Lacoursiere RE, Pruneda JN, Cohen MS.   +3 more
europepmc   +1 more source

DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint. [PDF]

DNA Repair (Amst)
Khan MM, Roos WP, Pearson CR, Leonard SM, Angajala A, Gibbs DY, Liu JC, Ragin C, Sobol RW.   +8 more
europepmc   +1 more source