Results 111 to 120 of about 2,704 (153)

ADP-ribosyl cyclase couples to cyclic AMP signaling in the cardiomyocytes

Biochemical and Biophysical Research Communications, 2005
ADP-ribosyl cyclase (ADPR-cyclase) produces a Ca(2+)-mobilizing second messenger cyclic ADP-ribose (cADPR) from beta-NAD(+). In this study, we examined the molecular basis of which beta-adrenergic receptor (betaAR) stimulation induces cADPR formation and characterized cardiac ADPR-cyclase.
Uh-Hyun Kim, Tae-Sik Nam, Ki-Chan Ha
exaly   +3 more sources

Crystallization of ADP‐ribosyl cyclase from Aplysia californica

Proteins: Structure, Function, and Genetics, 1996
ADP-ribosyl cyclase synthesizes the secondary messenger cyclic ADP-ribose from NAD+. Diffraction quality crystals of the enzyme from ovotestes of Aplysia californica have been obtained. Crystallographic analysis of this enzyme will yield insight into the mode of binding of the novel cyclic nucleotide and the mechanism by which NAD+ is cyclized.
Lee, HC, Prasad, GS, Levitt, DG, Stout, CD   +3 more
openaire   +3 more sources

Purification and characterization of CD38/ADP‐ribosyl cyclase from rat lung [PDF]

IUBMB Life, 1998
AbstractPurification and characterization of CD38/ADP‐ribosyl cyctase in the rat lung tissue was performed with microsomes solubilized in Triton X‐100 and the ADP‐ribosyl cyclase was then purified using sequential column chromatography. Partially purified rat lung ADP‐ribosyl cyclase was analyzed by immunoblotting using an antibody raised against a ...
C F Chang
exaly   +3 more sources

Role of kidney ADP-ribosyl cyclase in diabetic nephropathy

American Journal of Physiology-Renal Physiology, 2009
The role of ADP-ribosyl cyclases (ADPR-cyclases) in diabetic nephropathy was investigated. ADPR-cyclases synthesize cADP-ribose (cADPR), a Ca2+-mobilizing second messenger, and are stimulated by G protein-coupled receptors. We have previously reported that ADPR-cyclases can be activated by ANG II and showed that a specific kidney ADPR-cyclase inhibitor,
Seon-Young, Kim, Kwang-Hyun, Park, Rukhsana, Gul, Kyu Yoon, Jang, Uh-Hyun, Kim   +4 more
openaire   +2 more sources

ADP ribosyl-cyclases (CD38/CD157), social skills and friendship

Psychoneuroendocrinology, 2017
Why some individuals seek social engagement while others shy away has profound implications for normal and pathological human behavior. Evidence suggests that oxytocin (OT), the paramount human social hormone, and CD38 that governs OT release, contribute to individual differences in social skills from intense social involvement to extreme avoidance ...
Anne, Chong, Fabio, Malavasi, Salomon, Israel, Chiea Chuen, Khor, Von Bing, Yap, Mikhail, Monakhov, Soo Hong, Chew, Poh San, Lai, Richard P, Ebstein   +8 more
openaire   +2 more sources

GTP stabilization of adenylate cyclase activated and ADP-ribosylated by choleragen

Biochemical and Biophysical Research Communications, 1981
Abstract Choleragen activates adenylate cyclase in human skin fibroblasts by catalyzing the ADP-ribosylation of the 42,000 and 47,000 dalton guanyl nucleotide-binding regulatory components (G) of adenylate cyclase. The ADP-ribose linkage to 42,000 and 47,000 dalton proteins was stable at 30°C for 1 h with or without GTP, whereas GTP was required to ...
S, Nakaya, P A, Watkins, A J, Bitonti, L M, Hjelmeland, J, Moss, M, Vaughan   +5 more
openaire   +2 more sources

Purification and Characterization of ADP-Ribosyl Cyclase from Euglena gracilis

Journal of Biochemistry, 1999
ADP-ribosyl cyclase, which catalyzes the conversion from NAD+ to cyclic adenosine diphosphoribose (cADPR), is proposed to participate in cell cycle regulation in Euglena gracilis. This enzyme, which was found as a membrane-bound protein, was purified almost the homogeneity after solubilization with deoxycholate, and found to be a monomeric protein with
W, Masuda, S, Takenaka, S, Tsuyama, H, Inui, K, Miyatake, Y, Nakano   +5 more
openaire   +2 more sources

The expression of messenger RNA for ADP‐ribosyl cyclase in aldosterone‐producing adenomas

Clinical Endocrinology, 2005
SummaryObjective  Cyclic ADP‐ribose (cADPR) has been reported to be as potent and powerful at releasing intracellular Ca2+ as inositol triphosphate (IP3). To determine whether the cADPR system plays a signalling role in angiotensin II (Ang II)‐induced aldosterone synthesis in the human adrenal gland, we investigated the effects of Ang II on ADP‐ribosyl
Yoshiyu, Takeda, Mikiya, Usukura, Takashi, Yoneda, Nobushige, Oda, Yoko, Ito, Hiroshi, Mabuchi   +5 more
openaire   +2 more sources

A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis

Nature Cell Biology, 1999
Nucleoplasmic calcium ions (Ca2+) influence nuclear functions as critical as gene transcription, apoptosis, DNA repair, topoisomerase activation and polymerase unfolding. Although both inositol trisphosphate receptors and ryanodine receptors, types of Ca2+ channel, are present in the nuclear membrane, their role in the homeostasis of nuclear Ca2 ...
O A, Adebanjo, H K, Anandatheerthavarada, A P, Koval, B S, Moonga, G, Biswas, L, Sun, B R, Sodam, P J, Bevis, C L, Huang, S, Epstein, F A, Lai, N G, Avadhani, M, Zaidi   +12 more
openaire   +2 more sources

ADP-ribosylation of brain synaptosomal proteins correlates with adenylate cyclase activation

Biochemical and Biophysical Research Communications, 1982
Abstract ADP-ribosylation of the adenylate cyclase G F regulatory subunit by cholera toxin is a major tool for the study of this enzyme. Investigation of the brain enzyme has been hampered up to now by the failure to demonstrate cholera toxin-dependent ADP-ribosylation of membrane-bound proteins.
G, Berthillier, J, d'Alayer, A, Monneron
openaire   +2 more sources