Results 111 to 120 of about 10,542 (222)

The Ca2+-dependent Binding of Calmodulin to an N-terminal Motif of the Heterotrimeric G Protein beta Subunit [PDF]

, 1997
Ca2+ ion concentration changes are critical events in signal transduction. The Ca2+-dependent interactions of calmodulin (CaM) with its target proteins play an essential role in a variety of cellular functions.
Liu, Mingyao, Nakanishi, Osamu, Simon, Melvin, Wieland, Thomas, Yu, Bo   +4 more
core  

The two-pore channel TPCN2 mediates NAADP-dependent Ca-release from lysosomal stores [PDF]

, 2009
Second messenger-induced Ca2+-release from intracellular stores plays a key role in a multitude of physiological processes. In addition to 1,4,5-inositol trisphosphate (IP3), Ca2+, and cyclic ADP ribose (cADPR) that trigger Ca2+-release from the ...
Xiangang Zong, Michael Schieder, Hartmut Cuny, Stefanie Fenske, Christian Gruner, Katrin Rötzer, Oliver Griesbeck, Hartmann Harz, Martin Biel, Christian Wahl-Schott, A Beck, G Berridge, MJ Berridge, FX Boittin, EJ Bowman, LM Broad, PJ Calcraft, JM Cancela, D Churamani, GC Churchill, DE Clapham, DE Clapham, A Galione, A Galione, JV Gerasimenko, G Grynkiewicz, AH Guse, K Ishibashi, HC Lee, HC Lee, F Malavasi, R Masgrau, K Mikoshiba, AJ Morgan, B Much, E Peiter, BC Schroeder, M Steen, H Streb, C Wahl-Schott, FH Yu, R Zalk, N Zerangue   +42 more
core   +1 more source

Regulation of Nuclear Ca2+ Signaling by Translocation of the Ca2+ Messenger Synthesizing Enzyme ADP-ribosyl Cyclase during Neuronal Depolarization*

Journal of Biological Chemistry, 2008
In neurons, voltage-gated Ca2+ channels and nuclear Ca2+ signaling play important roles, such as in the regulation of gene expression. However, the link between electrical activity and biochemical cascade activation involved in the generation of the ...
S. Bezin, G. Charpentier, Hon-cheung Lee, G. Baux, P. Fossier, J. Cancela   +5 more
semanticscholar   +1 more source

ANTI-CD38 MONOCLONAL ANTIBODIES: TRANSFORMING MULTIPLE MYELOMA TREATMENT

Hematology, Transfusion and Cell Therapy
Introduction: Multiple myeloma (MM) is a neoplasm defined by the clonal proliferation of malignant plasma cells (PC) within the bone marrow (BM).
Cem Selim
doaj   +1 more source

Crystal structure of ADP-ribosyl cyclase [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 1996
C. D. Stout, G. Sridhar Prasad, E. A. Stura, D. E. McRee, D. G. Levitt, H. C. Lee   +5 more
openaire   +1 more source

ZFP36 proteins and mRNA targets in B cell malignancies [PDF]

, 2015
The ZFP36 proteins are a family of post-transcriptional regulator proteins that bind to adenine uridine rich elements (AREs) in 3’ untranslated (3’UTR) regions of mRNAs.
Alcaraz, A., Alcaraz, A.
core  

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. [PDF]

, 2002
The yeast silent information regulator (Sir)2 protein links cellular metabolism and transcriptional silencing through its nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase activity.
Frye, Roy A, North, Brian J, Ott, Melanie, Schwer, Bjorn, Verdin, Eric   +4 more
core  

CD38 as theranostic target in oncology

Journal of Translational Medicine
CD38 is a multifunctional transmembrane glycoprotein found in multiple tissues and overexpressed in many cancer cells, notably in hematological malignancies such as leukemia and multiple myeloma (MM).
Valentina Bocuzzi, Jessica Bridoux, Michelle Pirotte, Nadia Withofs, Roland Hustinx, Matthias D’Huyvetter, Jo Caers, Guillaume Marcion   +7 more
doaj   +1 more source

NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in Arabidopsis. [PDF]

, 2019
The 5' end of a eukaryotic mRNA transcript generally has a 7-methylguanosine (m7G) cap that protects mRNA from degradation and mediates almost all other aspects of gene expression.
Cai, Zongwei, Chen, Xuemei, Ni, Min, Shao, Xiaojian, Xia, Yiji, Zhang, Hailei, Zhang, Shoudong, Zhong, Huan   +7 more
core  

The CD38/CD157 mammalian gene family: An evolutionary paradigm for other leukocyte surface enzymes [PDF]

, 2006

core   +1 more source