Results 111 to 120 of about 188,515 (292)

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Identification of the Mouse T Cell ADP-Ribosylome Uncovers ARTC2.2 Mediated Regulation of CD73 by ADP-Ribosylation

Frontiers in Immunology, 2021
Mouse T cells express the ecto-ADP-ribosyltransferase ARTC2.2, which can transfer the ADP-ribose group of extracellular nicotinamide adenine dinucleotide (NAD+) to arginine residues of various cell surface proteins thereby influencing their function ...
Mario Leutert, Mario Leutert, Yinghui Duan, Riekje Winzer, Stephan Menzel, Stephan Menzel, Eva Tolosa, Tim Magnus, Michael O. Hottiger, Friedrich Koch-Nolte, Björn Rissiek   +10 more
doaj   +1 more source

Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]

, 1990
Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland, Wenzel-Seifert, Katharina   +1 more
core   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Serine ADP-Ribosylation Depends on HPF1

Molecules and Cells, 2017
Summary ADP-ribosylation (ADPr) regulates important patho-physiological processes through its attachment to different amino acids in proteins. Recently, by precision mapping on all possible amino acid residues, we identified histone serine ADPr marks in ...
J. Bonfiglio, P. Fontana, Qi Zhang, T. Colby, Ian Gibbs-Seymour, I. Atanassov, Edward J. Bartlett, R. Žaja, I. Ahel, I. Matic   +9 more
semanticscholar   +1 more source

G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma [PDF]

, 1992
Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) consist of a nucleotide-binding alpha subunit and a high- affinity complex of beta and gamma subunits.
Gilman, Alfred G., Iñiguez-Lluhi, Jorge A., Robishaw, Janet D., Simon, Melvin I.   +3 more
core  

Control of T lymphocyte morphology by the GTPase Rho [PDF]

, 2003
Background Rho family GTPase regulation of the actin cytoskeleton governs a variety of cell responses. In this report, we have analyzed the role of the GTPase Rho in maintenance of the T lymphocyte actin cytoskeleton.
Woodside, Darren G, Wooten, David K, Teague, T Kent, Miyamoto, Yuko J, Caudell, Eva G, Udagawa, Taturo, Andruss, Bernard F, McIntyre, Bradley W   +7 more
core   +2 more sources

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses

Cell Discovery, 2021
Signaling cascades provide integrative and interactive frameworks that allow the cell to respond to signals from its environment and/or from within the cell itself.
Flurina Boehi, Patrick Manetsch, Michael O. Hottiger   +2 more
doaj   +1 more source

A toxin hunter in the microworld of bacteria: a project on novel inhibitors against bacterial AB5 toxins [PDF]

, 2016
[要旨] 病原性細菌が産生する蛋白性のAB5型トキシンは1個のAサブユニットと5個のBサブユニットから構成される外毒素である。両サブユニットはそれぞれ特徴的な役割を持ち，互いに巧妙に機能分担をして一つのトキシンを形成している。Aサブユニットは主に毒性に直接関与する特異的な酵素活性を有する。一方，Bサブユニットは標的細胞のレセプターに対する結合能を有し，AB5型トキシンを標的細胞に吸着させる。ここでは毒性が全く異なるAB5型トキシンとして，コレラ菌が産生するコレラトキシン（CT ...
Fujun Shen (314092), Jiandong Yang (196004), Rong Hou (149003), Yang Da (89805)   +3 more
core   +3 more sources