Results 131 to 140 of about 214,575 (242)
Reversible ADP-ribosylation of the 78 kDa glucose-regulated protein
, 1990 Starvation of Mouse hepatoma cells for essential amino acids or glucose results in the mono-ADP-ribosylation of the 78 kDa glucose-regulated protein, GRP78. Here we show that the ADP-ribosylated and non-ADP-ribosylated forms of GRP78 are interconvertible
Ledford, Barry E. +3 more
core +1 more source
The PARP1/ARTD1-Mediated Poly-ADP-Ribosylation and DNA Damage Repair in B Cell Diversification
Antibodies, 2014 ADP-ribosylation is an essential post-translational modification, mediated by a family of proteins named poly-ADP-ribose polymerases/Diphtheria toxin-like ADP-ribosyltransferases (PARPs/ARTDs), that functions to assist in cellular homeostasis through an ...
Jackline J.M. Lasola +3 more
doaj +1 more source
Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation
Cells, 2019 Cells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD+, a coenzyme in redox reactions, also mediates several ubiquitous cell
Ann-Katrin Hopp, P. Grüter, M. Hottiger
semanticscholar +1 more source
Scientific Reports, 2018 Macrodomains are conserved protein folds associated with ADP-ribose binding and turnover. ADP-ribosylation is a posttranslational modification catalyzed primarily by ARTD (aka PARP) enzymes in cells.
Mareike Bütepage +15 more
doaj +1 more source
Modulation of endogenous ADP-ribosylation in rat brain
, 1992 Endogenous ADP-ribosylation of proteins was measured in homogenates, membranes, and cytosol from rat brain regions. Several proteins were ADP-ribosylated in homogenates, especially a 49 kDa protein.
Jope, Richard S +3 more
core +1 more source
ADP-ribosylation of BSA by Pertussigen Follows the same Mechanism as ADP-ribosylation of Transducine
, 1986 Pertussigen is a toxin responsible for the ADP-ribosylation of the Adenylate cyclase system inhibitory component. It has been verified through polyacrylamide gel electrophoresis that the ADP-ribosylation occurs only if the reaction mixture is ...
Cabrera, John
core
A Clickable Aminooxy Probe for Monitoring Cellular ADP-Ribosylation
, 2015 ADP-ribosylation is essential for cell function, yet there is a dearth of methods for detecting this post-translational modification in cells. Here, we describe a clickable aminooxy alkyne (AO-alkyne) probe that can detect cellular ADP-ribosylation on ...
Rory K. Morgan (1545481) +1 more
core +1 more source
Identification of ADP-ribosylation site in human glutamate dehydrogenase isozymes
, 2005 When the influence of ADP-ribosylation on the activities of the purified human glutamate dehydrogenase isozymes (hGDH1 and hGDH2) was measured in the presence of 100μM NAD+ for 60min, hGDH isozymes were inhibited by up to 75%.
Seung-Ju Yang +11 more
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PARP7 is a proteotoxic stress sensor that labels proteins for degradation
The EMBO JournalADP-ribosylation is a post-translational modification that plays a critical role in cellular stress responses. We have observed that during proteotoxic stress, cellular ADP-ribosylation increases, with ADP-ribosylated proteins accumulating in cytoplasmic
Nonso J Ikenga +4 more
doaj +1 more source
Poly(ADP-ribosylation) of a DNA topoisomerase [PDF]
, 1983 journal articleA DNA topoisomerase activity, copurifying with poly(ADP-ribose) synthetase from calf thymus, >95% inhibited if extensive poly(ADP-ribosylation) is allowed to occur.
Ferro, Ari M.; Higgins, N. Patrick +1 more
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