Results 121 to 130 of about 61,359 (235)

Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain

Nature Communications
ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major family in this category.
Zhengrui Zhang, Jiaqi Fu, Johannes Gregor Matthias Rack, Chuang Li, Jim Voorneveld, Dmitri V. Filippov, Ivan Ahel, Zhao-Qing Luo, Chittaranjan Das   +8 more
doaj   +1 more source

Mitokondriális eredetű nitrogén szabadgyökök és ATP-függő K-csatornák szerepe az organellum működésében = The involvement of mitochondrial-derived nitrogen radicals and mitoK-ATP channels in the regulation of organelle function [PDF]

, 2009
Elsőként a mitoKATP csatornák alegységeit terveztük azonosítani humán szív mintákon. A kísérletek során megbizonyosodtunk afelől, hogy a korábban ilyen csatornáknak gondolt fehérjék nincsenek jelen megfelelő számban és formában a mitokondriális ...
Csordás, Attila, Horváth, Eszter Mária, Lacza, Zsombor, Pankotai, Eszter, Szabó, Csaba   +4 more
core  

Comprehensive methylome map of lineage commitment from haematopoietic progenitors. [PDF]

, 2010
Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged.
Aryee, Martin J, Daley, George Q, Doi, Akiko, Ehrlich, Lauren IR, Feinberg, Andrew P, Ho, Lena, Inlay, Matthew A, Irizarry, Rafael A, Ji, Hong, Karsunky, Holger, Kim, Kitai, Lee, Hwajin, Lindau, Paul, Murakami, Peter, Rossi, Derrick J, Seita, Jun, Serwold, Thomas, Weissman, Irving L   +17 more
core   +2 more sources

CD24 in Melanoma: Biomarker, Innate Immune Checkpoint and Emerging Therapeutic Target

Experimental Dermatology, Volume 35, Issue 5, May 2026.
ABSTRACT Immune checkpoint inhibitors have transformed the treatment of advanced melanoma, yet many patients develop primary or acquired resistance. Although most work has focused on adaptive checkpoints (PD‐1 and CTLA‐4), accumulating evidence implicates innate immune suppression and stem‐like, drug‐resistant melanoma cell states.
Claudia Lasalle, Rachel C. Chang, Nicole C. Nowak, Yulu Wang, Alessio Giubellino, Kyle T. Amber, Adrian P. Mansini   +6 more
wiley   +1 more source

Uncoupling of DNA excision repair and nucleosomal unfolding in poly (ADP-ribose)-depleted mammalian cells [PDF]

, 2017
The repair of DNA damage in eukaryotic cells is closely coupled with local changes of chromatin structure such that newly synthesized repair patches transiently appear in ‘free' DNA domains with increased accessibility to enzymatic and chemical probes ...
Althaus, Felix R., Mathis, Georg
core  

ZmNPSN13 Potentiates Maize Rough Dwarf Disease Upon Recruitment by the RBSDV P7‐1 Effector

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
ZmNPSN13 serves as an additional host target of P7‐1 and forms a pathogenic complex with ZmGDIα and ZmGA2ox7.3, which is disrupted by replacing ZmGDIα with ZmGDIα‐hel. Knockout of ZmNPSN13 restores hormonal balance and enhances resistance to MRDD. ABSTRACT Maize rough dwarf disease (MRDD), caused by fijiviruses, poses a major threat to global maize ...
Suining Deng, Yixiao Qin, Baoshen Liu, Siqi Jiang, Tao Zhong, Qingcai Liu, Jianju Liu, Yuanliang Liu, Manman Li, Yanmei Li, Mingzhu Yan, Qian Li, Mingliang Xu   +12 more
wiley   +1 more source

Arginine-Specific Mono ADP-Ribosylation In Vitro of Antimicrobial Peptides by ADP-Ribosylating Toxins

PLoS ONE, 2012
Among the several toxins used by pathogenic bacteria to target eukaryotic host cells, proteins that exert ADP-ribosylation activity represent a large and studied family of dangerous and potentially lethal toxins. These proteins alter cell physiology catalyzing the transfer of the ADP-ribose unit from NAD to cellular proteins involved in key metabolic ...
Castagnini M, Picchianti M, Talluri E, Biagini M, Del Vecchio M, Di Procolo P, Norais N, Nardi Dei V, BALDUCCI, Enrico   +8 more
openaire   +5 more sources

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.

PLoS Pathogens, 2019
ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible diphtheria toxin-like enzymes known as PARPs.
Matthew E Grunewald, Yating Chen, Chad Kuny, Takashi Maejima, Robert Lease, Dana Ferraris, Masanori Aikawa, Christopher S Sullivan, Stanley Perlman, Anthony R Fehr   +9 more
doaj   +1 more source

A Highly Conserved SNARE‐Associated Protein Enhances Plant Immunity by Regulating Vesicle Trafficking

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3426-3440, May 2026.
ABSTRACT The plant endomembrane system and vesicle trafficking are central to plant immunity, mediating the targeted delivery and recycling of defence molecules during pathogen attack. Here, we investigated the functional role of soybean Vacuole Membrane Protein 1 (GmVMP1) in mediating resistance against soybean cyst nematode (SCN, Heterodera glycines).
Tracy E. Hawk, Peitong Li, Hafiz Muhammad Khalid Abbas, Mst Shamira Sultana, Sarbottam Piya, Nicole Coffey, Cengizhan Öztürk, Sobhan Bahrami Zadegan, Susan Thomas Laird, Mazen Alazem, Samantha P. Nuzzi, J. Hollis Rice, Chris Wyman, Tessa Burch‐Smith, Vince Pantalone, Tarek Hewezi   +15 more
wiley   +1 more source

The Role of Histone Modifications in Plant Priming and Their Analysis by Chromatin Immunoprecipitation

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT Plants are frequently exposed to adverse conditions. Priming, also known as acclimation or hardening, induces stress memory and prepares plants for future challenges by activating defense and protective mechanisms. For this reason, priming is an effective means to maintain plant yield in the face of climate change. Memory behind the priming is
Aslihan Temel, Nihal Gören‐Sağlam
wiley   +1 more source