Results 111 to 120 of about 61,359 (235)

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]

, 2009
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo, Jae-Hyun Park, Jung-Won Kim, Meng-Lay Lin, Miki Akiyama, Tatsuhiko Tsunoda, Tomomi Ueki, Toshihiko Nishidate, Toyomasa Katagiri, Yataro Daigo, Yusuke Nakamura   +10 more
core   +2 more sources

Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

Arthritis &Rheumatology, Volume 78, Issue 5, Page 1045-1061, May 2026.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin, Wenzhen Li, Xinyu A, Jun Shen, Xiaohui Meng, Yanqin Bian, Haihui Han, Zheng Xiang, Lei Ran, Songtao Sun, Jun Xie, Tao Yue, Qi Zhu, Xiaoming Zhang, Lu Xie, Lianbo Xiao   +15 more
wiley   +1 more source

5-HT2A receptor signalling through phospholipase D1 associated with its C-terminal tail [PDF]

, 2011
The 5-HT2AR (5-hydroxytryptamine-2A receptor) is a GPCR (G-protein-coupled receptor) that is implicated in the actions of hallucinogens and represents a major target of atypical antipsychotic agents.
Abbas, Banes, Berg, Bhattacharya, Cockcroft, Dean, Derek N. Robertson, Du, Du, Du, Eve M. Lutz, Fensome, Garrido, Gonzalez-Maeso, Gooz, Guillet-Deniau, Hammond, Hanke, Heuss, Hoyer, Ichikawa, Johnson, Johnson-Farley, Klein, Koch, Kurrasch-Orbaugh, Kurrasch-Orbaugh, Lavieri, Lee, Lehmann, Liting Sun, Louise Dickson, McCulloch, Melanie S. Johnson, Mitchell, Mitchell, Mitchell, Moya, Pamela J. Holland, Pehek, Perez-Mansilla, Quinn, Rajagopal, Rankovic, Rizzo, Roberta Rosie, Robertson, Rory Mitchell, Roth, Schmid, Schmidt, Scott, Shome, Sue Fleetwood-Walker, Sun, Tian, Yu, Zeniou-Meyer, Zoë Barclay   +58 more
core   +3 more sources

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

Tissue‐specific targeting of the ARF6 signalling axis for type 2 diabetes and obesity: From mechanism to nanodelivery

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Multitissue targeting and nanodelivery strategies centred on ADP‐ribosylation factor 6 for type 2 diabetes and insulin resistance. Abstract Disorders of glucose metabolism, particularly type 2 diabetes and obesity, remain major therapeutic challenges because they involve dysfunction across multiple tissues, including pancreatic β‐cells, peripheral ...
Yangyang Wang, Yan He, Zhiming Xiu, Huiyan Wang   +3 more
wiley   +1 more source

PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation

The EMBO Journal
Protein ADP-ribosylation plays important but ill-defined roles in antiviral signalling cascades such as the interferon response. Several viruses of clinical interest, including coronaviruses, express hydrolases that reverse ADP-ribosylation catalysed by ...
Victoria Chaves Ribeiro, Lilian Cristina Russo, Nícolas Carlos Hoch   +2 more
doaj   +1 more source

Proteomic Analysis of Cervicovaginal Fluid for Diagnostic Endometriosis Biomarker Discovery

PROTEOMICS – Clinical Applications, Volume 20, Issue 3, May 2026.
ABSTRACT Purpose Endometriosis is a prevalent inflammatory condition characterised by the presence of endometrial‐like tissue outside the uterus and is associated with significant challenges, including diagnostic delays and continued reliance on laparoscopy.
Emily S. J. Paterson, Simon Scheck, Torsten Kleffmann, Roopi Gill, Nicholas Bedford, Simon McDowell, Jane E. Girling, Claire E. Henry   +7 more
wiley   +1 more source

Opposite Regulatory Effects of Iron Ions on the In Vitro Catalytic Activities of NarE, the Toxin-like ADP-ribosyltransferase from Neisseria meningitidis [PDF]

, 2015
NarE, the mono ADP-ribosyltransferase identified in Neisseria meningitidis, catalyzes three enzymatic reactions. NarE transfers a single ADP-ribose unit to guanidine compounds, hydrolyses NAD in nicotinamide and free ADP-ribose, and ADP-ribosylates ...
Balducci, Enrico, Del Vecchio, Mariangela   +1 more
core   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, Volume 183, Issue 10, Page 2219-2235, May 2026.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source