Results 41 to 50 of about 188,515 (292)
Temporal and Site-Specific ADP-Ribosylation Dynamics upon Different Genotoxic Stresses
Cells, 2021 The DNA damage response revolves around transmission of information via post-translational modifications, including reversible protein ADP-ribosylation.
Sara C. Buch-Larsen +3 more
doaj +1 more source
Chemoenzymatic and Synthetic Approaches To Investigate Aspartate- and Glutamate-ADP-Ribosylation.
Journal of the American Chemical Society, 2023 We report here chemoenzymatic and fully synthetic methodologies to modify aspartate and glutamate side chains with ADP-ribose at specific sites on peptides. Structural analysis of aspartate and glutamate ADP-ribosylated peptides reveals near-quantitative
Kyuto Tashiro +6 more
semanticscholar +1 more source
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels. [PDF]
Nat CommunCherdyntseva V +11 more
europepmc +3 more sources
Molecular basis for the reversible ADP-ribosylation of guanosine bases
Molecules and Cells, 2023 Summary Modification of nucleic acids by ADP-ribosylation is catalyzed by various ADP-ribosyltransferases, including the DarT enzyme. The latter is part of the bacterial toxin-antitoxin (TA) system DarTG, which was shown to provide control of DNA ...
M. Schuller +9 more
semanticscholar +1 more source
iScience, 2021 Summary: While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation of fibroblasts to myoblasts promotes
Lavinia Bisceglie +11 more
doaj +1 more source
Mono-ADP-ribosylation by PARP10 and PARP14 in genome stability
NAR Cancer, 2023 ADP-ribosylation is a post-translational modification involved in a variety of processes including DNA damage repair, transcriptional regulation, and cellular proliferation.
Ashna Dhoonmoon, Claudia M. Nicolae
semanticscholar +1 more source
Cell Reports, 2020 Summary: ADP-ribosylation of proteins is crucial for fundamental cellular processes. Despite increasing examples of DNA ADP-ribosylation, the impact of this modification on DNA metabolism and cell physiology is unknown. Here, we show that the DarTG toxin-
Emeline Lawarée +5 more
doaj +1 more source
Selective monitoring of the protein-free ADP-ribose released by ADP-ribosylation reversal enzymes.
PLoS ONE, 2021 ADP-ribosylation is a key post-translational modification that regulates a wide variety of cellular stress responses. The ADP-ribosylation cycle is maintained by writers and erasers.
Samuel Kasson +2 more
doaj +1 more source
Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response
Life Science Alliance, 2021 This work studies known and new ADPRHL2 mutations with different disease mechanisms overall indicating that loss of nuclear ARH3 alone is pathogenic via dysregulated nuclear ADP ribosylation.
Danique Beijer +10 more
doaj +1 more source
bioRxiv, 2021 SARS-CoV-2 non-structural protein 3 (Nsp3) contains a macrodomain that is essential for virus replication and is thus an attractive target for drug development.
L. Russo +11 more
semanticscholar +1 more source