Results 41 to 50 of about 213,935 (349)

Score predictor factor analysis: Reproducing observed covariances by means of factor score predictors [PDF]

Front. Psychol. 10:1895 (2019), 2019
The model implied by factor score predictors does not reproduce the non-diagonal elements of the observed covariance matrix as well as the factor loadings. It is therefore investigated whether it is possible to estimate factor loadings for which the model implied by the factor score predictors optimally reproduces the non-diagonal elements of the ...
arxiv   +1 more source

BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity.

Molecular Biology of the Cell, 2004
Small GTPases of the ADP-ribosylation factor (ARF) family play a key role in membrane trafficking by regulating coated vesicle formation, and guanine nucleotide exchange is essential for the ARF function.
Hye-Won Shin, N. Morinaga, M. Noda, K. Nakayama   +3 more
semanticscholar   +1 more source

PARP-3 and APLF function together to accelerate nonhomologous end joining [PDF]

, 2010
PARP-3 is a member of the ADP-ribosyl transferase superfamily of unknown function. We show that PARP-3 is stimulated by DNA double-strand breaks (DSBs) in vitro and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate
Ahel, Ame, Anna E.O. Fisher, Audebert, Bekker-Jensen, Benjamin, Bernardo Reina-San-Martin, Boulton, Brown, Bryant, Bryant, Caldecott, Caldecott, Critchlow, Ding, Drouet, El-Khamisy, Farmer, Fisher, Grawunder, Guy Poirier, Hochegger, Hottiger, Iles, Isabelle Robert, Kanno, Keith W. Caldecott, Kickhoefer, Kleine, Le Page, Lehtio, Limei Ju, Lobrich, Loseva, Macrae, Mahaney, Maria C. Zuma, Mehrotra, Michele Rouleau, Morrison, Okano, Otto, Poirier, Robert, Roberts, Rogakou, Rogakou, Rouleau, Rulten, Smith, Soulas-Sprauel, Stevnsner, Stuart L. Rulten, Sugimura, Trucco, Wang, Yan, Yang, Yano, Yano   +59 more
core   +1 more source

Binding immunoglobulin 2 functions as a proviral factor for potyvirus infections in Nicotiana benthamiana

Molecular Plant Pathology, Volume 24, Issue 2, Page 179-187, February 2023., 2023
Interaction between binding immunoglobulin protein 2 (BiP2) and NIb of potyvirus promotes virus infections, making BiP2 a good candidate for gene modification to generate a resistant cultivar against potyviruses. Abstract Infection of viruses from the genera Bromovirus, Potyvirus, and Potexvirus in Nicotiana benthamiana induces significant up ...
Kristin Widyasari, John Bwalya, Kook‐Hyung Kim   +2 more
wiley   +1 more source

In Vivo Level of Poly(ADP-ribose)

Challenges, 2018
PolyADP-ribosylation is a post-translational modification that plays key roles in cellular physiological functions and DNA damage responses. PolyADP-ribosylation is finely and dynamically regulated by various enzymes and factors involved in the synthesis
Masanao Miwa, Chieri Ida, Sachiko Yamashita, Kenichi Kouyama, Yasuhito Kuroda, Takayuki Eguchi, Narumi Ohta, Teruaki Sato, Masataka Tsuda, Masakazu Tanaka   +9 more
doaj   +1 more source

Purification and Cloning of a Brefeldin A-inhibited Guanine Nucleotide-exchange Protein for ADP-ribosylation Factors*

Journal of Biological Chemistry, 1999
Activation of ADP-ribosylation factors (ARFs), ∼20-kDa guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking, depends on guanine nucleotide-exchange proteins (GEPs), which accelerate replacement of bound ...
Akira Togawa, N. Morinaga, M. Ogasawara, J. Moss, M. Vaughan   +4 more
semanticscholar   +1 more source

A novel physiological role for ARF1 in the formation of bidirectional tubules from the Golgi. [PDF]

, 2017
Capitalizing on CRISPR/Cas9 gene-editing techniques and super-resolution nanoscopy, we explore the role of the small GTPase ARF1 in mediating transport steps at the Golgi.
Baddeley, David, Bewersdorf, Joerg, Bottanelli, Francesca, Erdmann, Roman S, Ernst, Andreas M, Kilian, Nicole, Kromann, Emil B, Lessard, Mark D, Rivera-Molina, Felix, Rothman, James E, Schepartz, Alanna, Schroeder, Lena K, Toomre, Derek   +12 more
core   +2 more sources

ADP ribosylation factor regulates spectrin binding to the Golgi complex [PDF]

Proceedings of the National Academy of Sciences, 1998
Homologues of two major components of the well-characterized erythrocyte plasma-membrane-skeleton, spectrin (a not-yet-cloned isoform, βIΣ* spectrin) and ankyrin (Ank G119 and an ≈195-kDa ankyrin), associate with the Golgi complex. ADP ribosylation factor (ARF) is a small G protein that controls the architecture and
Godi, A, Santone, I, Pertile, P, Devarajan, P, Stabach, P. R, Morrow, J. S, Di Tullio, G, Polishchuk, R, Petrucci, T. C, Luini, A, DE MATTEIS, Maria Antonietta   +10 more
openaire   +4 more sources

The potential role and application of PARP inhibitors in cancer treatment [PDF]

, 2009
Background: Since many anti-cancer agents act by inflicting DNA damage on tumour cells, there is increasing interest in the use of inhibitors of DNA repair to increase the cytotoxicity of these agents.
Chalmers, Anthony J
core   +2 more sources

Filling in the GAPs in the ADP-ribosylation factor story [PDF]

Proceedings of the National Academy of Sciences, 2000
The GTP-binding proteins known as ADP-ribosylation factors (ARFs) function in cells to regulate membrane traffic and structure. Like all GTPases, ARFs cycle between a GDP-bound, inactive and a GTP-bound, active form. When GTP-bound, ARFs alter membrane lipid composition, assemble cytosolic coat proteins, and remodel actin associated with various ...
openaire   +3 more sources