Results 41 to 50 of about 46,883 (258)

Cloning and characterization of ADP-ribosylation factor 1b from the olive flounder Paralichthys olivaceus

Fisheries and Aquatic Sciences, 2017
Small GTPases are well known as one of the signal transduction factors of immune systems. The ADP-ribosylation factors (ARFs) can be classified into three groups based on the peptide sequence, protein molecular weight, gene structure, and phylogenetic ...
So-Hee Son, Jin-Hyeon Jang, Hyeon-Kyeong Jo, Joon-Ki Chung, Hyung-Ho Lee   +4 more
doaj   +1 more source

The small GTPase ARF6 regulates GABAergic synapse development

Molecular Brain, 2020
ADP ribosylation factors (ARFs) are a family of small GTPases composed of six members (ARF1–6) that control various cellular functions, including membrane trafficking and actin cytoskeletal rearrangement, in eukaryotic cells.
Hyeonho Kim, Hyeji Jung, Hyunsu Jung, Seok-Kyu Kwon, Jaewon Ko, Ji Won Um   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Shigella flexneri Regulation of ARF6 Activation during Bacterial Entry via an IpgD-Mediated Positive Feedback Loop

mBio, 2015
Entry into cells is critical for virulence of the human bacterial pathogens Shigella spp. Shigella spp. induce membrane ruffle formation and macropinocytic uptake, but the events instigating this process are incompletely understood. The host small GTPase
Anna Cristina Garza-Mayers, Kelly A. Miller, Brian C. Russo, Dipal V. Nagda, Marcia B. Goldberg   +4 more
doaj   +1 more source

Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]

, 2015
Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core  

Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]

, 1990
Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland, Wenzel-Seifert, Katharina   +1 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

PARP3 promotes macrophage inflammation via mono ADP ribosylation of Ppia Glu140

Molecular Medicine
Background Acute lung injury (ALI) carries significant mortality with limited targeted therapies. Macrophages drive early inflammatory propagation in ALI, exacerbating pulmonary inflammation.
Runjie Fan, Rongxing Zhu, Xiangxiu Cao, Shuhui Ye, Fengyi Gao, Yue Wu, Wanxin Yao, Guang Liang, Yanmei Zhang   +8 more
doaj   +1 more source

Structure ofPlasmodium falciparumADP-ribosylation factor 1 [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2010
Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 Å resolution and ...
William J, Cook, Craig D, Smith, Olga, Senkovich, Anthony A, Holder, Debasish, Chattopadhyay   +4 more
openaire   +2 more sources

Are guanine nucleotide binding proteins a distinct class of regulatory proteins? [PDF]

, 1983
Proteins which bind guanine nucleotides are found in a diverse set of key regulatory positions. They are involved in hormone action, visual transduction, protein synthesis and microtubule assembly. In addition to their ability to bind guanine nucleotides
Kleinzeller, Cassel, Martin, Pfeuffer, Hanski, Northup, Northup, Rodbell, Cooper, Houslay, Manning, Johnson, Bokoch, Zahniser, Stryer, Kuhn, Fung, Baehr, Hurley, Hughes, Yamazaki, Abood, Bitensky, Kawamura, Kawamura, Emeis, Swarup, Maitra, Schreier, Safer, Safer, Fakunding, Brot, Hachmann, Uchida, Collier, Montanaro, Beaudet, Laursen, Velenzuela, Spiegelman, Carlier, Zackroff, Weisenberg, Heyworth, Heyworth, Goodhardt, Shih, Capon, Willingham   +49 more
core   +1 more source