Results 101 to 110 of about 281,775 (299)
Advanced Science, EarlyView.ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung +19 more
wiley +1 more source
BIOCHEMICAL CHARACTERIZATION OF AUTO-ADP-RIBOSYLATED NARE
, 2011 Mono ADP-ribosylation is a post-translational modification, conserved in viruses, prokaryotes and eukaryotes. Several ADP-ribose transfer enzymes as ART2, ART5, ExoS and CT are able to modify themselves, changing their chemical and biological functions ...
M. Picchianti +2 more
core
Zadovoljstvo javnosti z delovanjem sodišč, 2017
, 2017 Komisija Sveta Evrope za učinkovitost pravosodja (CEPEJ) priporoča izvedbo raziskav zadovoljstva uporabnikov sodišč kot enega od načinov za ugotavljanje kakovosti pravosodja.
Vrabec, Jaša +7 more
core +1 more source
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source
Some features of primary facial erysipelas under the present conditions
Терапевтический архив, 2014 Aim: to establish the features of clinical and laboratory changes in facial erysipelas in relation to its form. MATERIALS AND METHODS. Twenty-three patients (15 women and 8 men) aged 31 to 78 years who were diagnosed with moderate facial erysipelas ...
E G Fokina
doaj
Molecular characterization of novel ADP-ribosyl cyclases from the sea urchin
, 2010 Calcium signalling is ubiquitous and regulates diverse cellular processes. Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are second messengers that are involved in calcium release from the intracellular organelles ...
Ramakrishnan, L.
core
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
, 2015 Raziskava je del raziskovalnega projekta Minas, ki je v obdobju od junija 2014 do decembra 2015 potekal v štirih evropskih državah: Slovenija, Avstrija, Francija in Združeno kraljestvo.
Žakelj, Tjaša +5 more
core +1 more source
Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy
Advanced Science, EarlyView.Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee +11 more
wiley +1 more source
Current OncologyBackground: Ultraviolet (UV) radiation is a major risk factor for skin cancer. Nevertheless, many people tan in the sun and in tanning beds. The aim of this study was to explore the reasons behind these behaviors and to investigate whether the reasons ...
Katharina Diehl +4 more
doaj +1 more source