Results 81 to 90 of about 281,775 (299)
ADP-Glo: A Bioluminescent and Homogeneous ADP Monitoring Assay for Kinases
ASSAY and Drug Development Technologies, 2009 ADP-Glo™ is a novel bioluminescent, homogeneous assay for monitoring ADP producing biochemical reactions and thus it is an ideal assay for detecting enzyme activity using a wide variety of substrates. It is a universal assay that can be used with protein kinases, lipid kinases, sugar kinases, and many more kinases as well as ATPases.
Hicham, Zegzouti +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
ADP-ribosylation from molecular mechanisms to therapeutic implications.
, 2023 ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life.
I Ahel (7716542) +3 more
core
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Evaluation of an Antibody-Free ADP Detection Assay: ADP-Glo
ASSAY and Drug Development Technologies, 2009 Identification of kinase, especially protein kinase, modulators through high-throughput screening (HTS) has become a common strategy for drug discovery programs in both academia and the pharmaceutical industry. There are a number of platform technologies that can be used for measuring kinase activities.
Hu, Li +6 more
openaire +2 more sources
Preprečevanje oboroženih konfliktov, 2012
, 2012 Teoretsko področje preprečevanja oboroženih konfliktov še ni ustrezno odgovorilo, na kak način naj mednarodne organizacije pristopijo k preprečevanju konflikta v določenem konfliktnem okolju (kakšne pristope, strategije in sredstva uporabiti) in kako ...
Zupančič, Rok
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Čezmejno povezovanje in lokalne skupnosti, 2015
, 2015 Na obmejnem območju Istre je bila izvedena študija primera (poglobljena terenska raziskava) med pripadniki italijanske narodne manjšine v hrvaški Istri.
Rameša, Martina +4 more
core +2 more sources
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Identification of ADP-ribosylated peptides and ADP-ribose acceptor sites
Frontiers in Bioscience, 2014 ADP-ribosylation is a post-translational modification of proteins that comprises the transfer of the ADP-ribose moiety from NAD+ to specific amino acid residues on substrate proteins or to ADP-ribose itself. It is catalyzed by ADP-ribosyltransferases, a family of currently 22 human proteins that all possess an ADP-ribosyltransferase catalytic domain ...
Rosenthal, Florian, Hottiger, Michael O
openaire +2 more sources