Results 71 to 80 of about 281,775 (299)

Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation

JCSM Rapid Communications, 2021
Background Mitochondrial bioenergetics are sensitive to adenosine diphosphate (ADP) concentration. Reactive oxygen species (ROS) production and respiration [oxygen consumption rate (OCR)] are altered at physiological ADP concentrations (i.e.
Gavin Pharaoh, Jacob Brown, Rojina Ranjit, Zoltan Ungvari, Holly Van Remmen   +4 more
doaj   +1 more source

A Poly-ADP-Ribose Polymer–GCSF Conjugate

, 2022
Poly-ADP-ribose (PAR) is a naturally occurring form of polymers synthesized through enzymatic reactions catalyzed by poly(ADP-ribose) polymerases (PARPs). It is known for regulating various important cellular signaling pathways and processes.
Lei Zhang (38117), Yong Zhang (5893), Jingwen Chen (489529), Xiao-Nan Zhang (1797094), Qinqin Cheng (5988329), Yiling Wang (620129)   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cellular adenylate energy charge and adenine nucleotides in brain tissue during hypoglycemia in newly born BALB/c mice pups

Exploration of Medicine
Aim: Hypoglycemia occurs in the neonatal period but the exact pathophysiology of the resulting brain injury at the cellular level is not well known. Therefore, a neonatal murine model was developed with insulin-induced hypoglycemia, to analyze the in ...
Hassib Narchi, Priyadharshini Yuvaraju, Junu A. George, Richard L. Jayaraj, Radhakrishnan Subramanian   +4 more
doaj   +1 more source

MiCREATE - Priseljeni otroci in priseljenske skupnosti v spreminjajoči se Evropi, 2021

, 2021
Projekt MiCreate (Migrant Children and Communities in a Transforming Europe) je mednarodni projekt, v okviru katerega je bila opravljena primerjalna raziskava v šolah, kjer so poleg Slovenije (koordinator projekta) sodelovale tudi Avstrija, Danska ...
Medarić, Zorana, Gornik, Barbara, Dežan, Lucija, Zadel, Maja, Sedmak, Mateja   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Storytelling in Mentoring: An Exploratory, Qualitative Study of Facilitating Learning in Developmental Interactions

SAGE Open, 2017
How is it that mentors teach—that protégé’s learn—that wisdom is shared between a mentor and protégé? This exploratory, qualitative study responds to a call in the literature to better understand what occurs in mentoring interactions by examining ...
Caroline P. D’Abate, Hali Alpert
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The role of purinergic signaling and cytokine network in the inflammatory process

Ветеринария сегодня
Introduction. Inflammation is a complex biological process essential for host defense against pathogens and tissue repair. This process is regulated by a variety of signaling molecules, among which purines and cytokines play an important role. Purinergic
V. V. Mosyagin, E. A. Isakova, G. F. Ryzhkova, I. P. Mosyagina   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source