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Platelet ADP Receptors and their Antagonists
Mini-Reviews in Medicinal Chemistry, 2003ADP plays a crucial role in haemostasis and thrombosis and its receptors are potential target for antithrombotic drugs. The knowledge of the ADP-receptors has been amplified by recent discoveries. This review highlights the ADP-receptors models and their antagonists described in the recent literature, mainly the thienopyridine derivatives.
Benoit, Patricia, Dogné, Jean-Michel
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Mono-ADP-Ribosylation Catalyzed by Arginine-Specific ADP-Ribosyltransferases
2018Methods are described for determination of arginine-specific mono-ADP-ribosyltransferase activity of purified proteins and intact cells by monitoring the transfer of ADP-ribose from NAD+ to a model substrate, e.g., arginine, agmatine, and peptide (human neutrophil peptide-1 [HNP1]), and for the nonenzymatic hydrolysis of ADP-ribose-arginine to ...
Linda A, Stevens, Joel, Moss
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Activation of Toxin ADP-Ribosyltransferases by the Family of ADP-Ribosylation Factors
1997ADP-ribosylation factors or ARFs are 20-kDa guanine nucleotide-binding proteins, initially identified as stimulators of cholera toxin-catalyzed ADP-ribosylation of Gs alpha. We now know that ARFs play a critical role in many vesicular trafficking events and ARF activation of a membrane-associated phospholipase D (PLD) has been recognized. ARF is active
M, Vaughan, J, Moss
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Enhancement by ADP of Thrombin-induced Aggregation in ADP-refractory Platelets
Thrombosis and Haemostasis, 1973SummaryIn ADP-refractory rat platelets, thrombin-induced aggregation is enhanced in the presence of ADP and inhibited in the absence of ADP. Two mechanisms are proposed for thrombin-induced platelet aggregation: one through ADP release which may become refractory, and a second mechanism in which thrombin acts synergistieally with ADP.
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The contents of adp systems work in administrative ADP applications
BIT, 1965An outline of the different phases in ADP work is presented. A detailed account is given of the purpose, contents, and results of each phase, and all inter-relations are illustrated in a flow chart.
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ADP receptors on platelets and ADP‐selective antiaggregating agents
Medicinal Research Reviews, 1996P, Savi, J M, Herbert
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Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation
Molecular Cell, 2021Corentin Gondrand +2 more
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An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation
Cell, 2020Juan JOSÉ Bonfiglio +2 more
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PARPs and ADP-ribosylation: Deciphering the complexity with molecular tools
Molecular Cell, 2023Morgan Dasovich, Anthony K L Leung
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