ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions [PDF]
Frontiers in Cell and Developmental Biology, 2022 Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li +3 more
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Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family (*) [PDF]
Journal of Biological Chemistry, 1995 Activation of phosphatidylcholine-specific phospholipase D (PLD) has been implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis.
S. Hammond +7 more
semanticscholar +2 more sources
Class I ADP-ribosylation factors are involved in enterovirus 71 replication.
PLoS ONE, 2014 Enterovirus 71 is one of the major causative agents of hand, foot, and mouth disease in infants and children. Replication of enterovirus 71 depends on host cellular factors.
Jianmin Wang, Jiang Du, Qi Jin
doaj +3 more sources
Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis. [PDF]
PLoS ONE, 2023 Atherosclerosis is the root cause of major cardiovascular diseases (CVD) such as myocardial infarction and stroke. ADP-ribosylation factor 6 (Arf6) is a ubiquitously expressed GTPase known to be involved in inflammation, vascular permeability and is ...
Venkateswara R Gogulamudi +9 more
doaj +2 more sources
Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance MARTX toxins present across multiple bacterial genera are primary virulence factors that facilitate initial colonization, dissemination, and lethality in a wide range of hosts, including humans. Upon entry into host cells, the toxins undergo
Lee Y +11 more
europepmc +2 more sources
Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1. [PDF]
Oncotarget, 2016 Metastasis is the major cause of cancer-related death in breast cancer patients, which is controlled by specific sets of genes. Targeting these genes may provide a means to delay cancer progression and allow local treatment to be more effective.
Xie X +7 more
europepmc +2 more sources
Cholesterol 25‐Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4 [PDF]
Advanced ScienceCholesterol 25‐hydroxylase (CH25H), an enzyme involved in cholesterol metabolism, regulates inflammatory responses and lipid metabolism. However, its role in kidney disease is not known.
Lu Zhang +12 more
doaj +2 more sources
ADP ribosylation factor-like GTPase 6-interacting protein 5 (ARL6IP5): a prenylated Rab acceptor protein 1 (PRA1) family protein that shapes the ER membrane and regulates ER-phagy [PDF]
Autophagy ReportsThe prenylated Rab acceptor protein 1 (PRA1) domain is a conserved domain encompassing four transmembrane domains (TMDs). ARL6IP5 (ADP ribosylation factor-like GTPase 6-interacting protein 5) is a member of the PRA1 family and interacts with the ...
Yasunori Yamamoto, Toshiaki Sakisaka
doaj +2 more sources
Role of ADP ribosylation factor guanylate kinase 1 in the malignant biological behavior of gastric cancer [PDF]
HeliyonAim: This study aims to investigate the influence of ASAP1 (ADP ribosylation factor guanylate kinase 1) on the malignant behavior of gastric cancer (GC) cells and to elucidate the potential molecular mechanisms involved in cancer development and ...
Qiong Luo +6 more
doaj +2 more sources
The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell Induction via Control of IL-2 Availability [PDF]
Cells, 2022 Interleukin-2 is central to the induction and maintenance of both natural (nTreg) and induced Foxp3-expressing regulatory T cells (iTreg). Thus, signals that modulate IL-2 availability may, in turn, also influence Treg homeostasis.
Bernd Geers +9 more
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