Results 91 to 100 of about 77,829 (292)

Bacterial Toxin Exploits Host Membrane Phospholipid as a Receptor for Binding, Entry, and Cytopathogenicity

Molecular Microbiology, EarlyView.
Mycoplasma pneumoniae pathogenesis relies on its CARDS toxin, which initiates cell binding and subsequent uptake by exploiting sphingomyelin, a key phospholipid found in the host plasma membrane. Maximal cellular entry and full cytotoxic effects are achieved through a synergistic mechanism that involves interaction with the protein coreceptor annexin ...
Alejandra M. Kirkpatrick, Thirumalai R. Kannan   +1 more
wiley   +1 more source

NAD+-dependent post-translational modification of Escherichia coli glyceraldehyde-3-phosphate dehydrogenase [PDF]

, 2009
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional housekeeping protein reported to be a target of several covalent modifications in many organisms.
Josefa Badia, Juan Aguilar, Laura Aguilera, Laura Baldoma, Rosa Giménez   +4 more
core   +6 more sources

CD13 regulation of membrane recycling: implications for cancer dissemination

Molecular & Cellular Oncology, 2019
Membrane recycling is critical to numerous cell functions and its dysregulation contributes to cancer and metastasis. We established that activation of the transmembrane molecule aminopeptidase N (ANPEP, also known as CD13) tethers the IQ motif ...
Mallika Ghosh, Linda H. Shapiro
doaj   +1 more source

Evidence that phospholipase D mediates ADP ribosylation factor- dependent formation of Golgi coated vesicles

Journal of Cell Biology, 1996
Formation of coatomer-coated vesicles from Golgi-enriched membranes requires the activation of a small GTP-binding protein, ADP ribosylation factor (ARF).
N. Ktistakis, H. Brown, M. G. Waters, P. Sternweis, Michael Roth   +4 more
semanticscholar   +1 more source

A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. [PDF]

, 2020
Clostridium difficile infections (CDIs) cause severe and occasionally life-threatening diarrhea. Hyper-virulent strains produce CDT, a toxin that ADP-ribosylates actin monomers and inhibits actin polymerization.
Bier, Ethan, Franc, Nathalie C, Guichard, Annabel, Roy, Sitara, Schwartz, Ruth   +4 more
core  

Are guanine nucleotide binding proteins a distinct class of regulatory proteins? [PDF]

, 1983
Proteins which bind guanine nucleotides are found in a diverse set of key regulatory positions. They are involved in hormone action, visual transduction, protein synthesis and microtubule assembly. In addition to their ability to bind guanine nucleotides
Kleinzeller, Cassel, Martin, Pfeuffer, Hanski, Northup, Northup, Rodbell, Cooper, Houslay, Manning, Johnson, Bokoch, Zahniser, Stryer, Kuhn, Fung, Baehr, Hurley, Hughes, Yamazaki, Abood, Bitensky, Kawamura, Kawamura, Emeis, Swarup, Maitra, Schreier, Safer, Safer, Fakunding, Brot, Hachmann, Uchida, Collier, Montanaro, Beaudet, Laursen, Velenzuela, Spiegelman, Carlier, Zackroff, Weisenberg, Heyworth, Heyworth, Goodhardt, Shih, Capon, Willingham   +49 more
core   +1 more source

Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection

New Phytologist, EarlyView.
Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Pepe Cana‐Quijada, Pablo Morales‐Martínez, Tábata Rosas‐Díaz, Jessica Pérez‐Sancho, Tamara Jiménez‐Góngora, José Antonio Navarro, Rosa Lozano‐Durán, Araceli G. Castillo, Vicente Pallás, Eduardo R. Bejarano   +9 more
wiley   +1 more source

TARG1 affects EGFR signaling through the regulation of RNA metabolism

Scientific Reports
Epidermal Growth Factor Receptor (EGFR) signaling plays a central role in cell proliferation, migration, and survival. Emerging evidence suggests a connection between ADP-ribosylation and EGFR regulation.
Mihály Mérey, Roberta Fajka-Boja, Gergely Imre, Péter Gudmann, Zsolt Török, Lajos Mátés, Ágnes Czibula, Gyula Timinszky   +7 more
doaj   +1 more source

CARF regulates the alternative splicing and piwi/piRNA complexes during mouse spermatogenesis through PABPC1

Acta Biochimica et Biophysica Sinica
ADP-ribosylation factor collaborator (CARF), which is also known as CDKN2AIP, was first recognized as an ADP-ribosylation factor-interacting protein that participates in the activation of the ARF-p53-p21 (WAF1 ...
Cao Yuming, Wang Shengnan, Liu Jie, Xu Jinfeng, Liang Yan, Ao Fei, Wei Zexiao, Wang Li   +7 more
doaj   +1 more source

Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses

Viruses, 2020
The guanine nucleotide exchange factor GBF1 is a well-known factor that can activate different ADP-ribosylation factor (Arf) proteins during the regulation of different cellular vesicular transport processes.
José L. Martínez, Carlos F. Arias
doaj   +1 more source