The Flavivirus NS3 Protein: Its Multifaceted Roles and Therapeutic Potential
Journal of Medical Virology, Volume 98, Issue 4, April 2026.Abstract Mosquito‐borne flaviviruses are important human pathogenic viruses and can cause an array of symptoms ranging from asymptomatic to mild illness but can progress to severe disease conditions. Prominent members of the family Flaviviridae include Dengue virus, Zika virus, and West Nile virus, whose spread has increased globally due to the ...
Haejeong Lee, Hee Cho, Michaela U. Gack
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Cell Propagation of Cholera Toxin CTA ADP-Ribosylating Factor by Exosome Mediated Transfer [PDF]
, 2018 In this study, we report how the cholera toxin (CT) A subunit (CTA), the enzyme moiety responsible for signaling alteration in host cells, enters the exosomal pathway, secretes extracellularly, transmits itself to a cell population.
Boussadia, Zaira +11 more
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Integration of epigenetics into ecotoxicology: insights and fundamental research needs
Biological Reviews, Volume 101, Issue 2, Page 826-847, April 2026.ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto +3 more
wiley +1 more source
mBio, 2019 ADP ribosylation factor (Arf) small GTPase family members are involved in vesicle trafficking and organelle maintenance in organisms ranging from Saccharomyces cerevisiae to humans.
Shengpei Zhang +13 more
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Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites [PDF]
, 2017 Poly(ADP-ribose) polymerase 1 (PARP1) synthesizes poly(ADP-ribose) (PAR) using nicotinamide adenine dinucleotide (NAD) as a substrate. Despite intensive research on the cellular functions of PARP1, the molecular mechanism of PAR formation has not been ...
Altmeyer, Matthias +4 more
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Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]
, 2009 Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo +10 more
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The role of ADP-ribosylation in regulating DNA interstrand crosslink repair [PDF]
, 2016 ADP-ribosylation by ADP-ribosyltransferases (ARTs) has a wellestablished role in DNA strand break repair by promoting enrichment of repair factors at damage sites through ADP-ribose interaction domains. Here, we exploit the simple eukaryote Dictyostelium
Ahel, Ivan +10 more
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Phages carry orphan antitoxin-like enzymes to neutralize the DarTG1 toxin-antitoxin defense system
Nature CommunicationsThe astounding number of anti-phage defenses encoded by bacteria is countered by an elaborate set of phage counter-defenses, though their evolutionary origins are often unknown. Here, we report the discovery of an orphan antitoxin counter-defense element
Anna Johannesman +3 more
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Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes. [PDF]
, 2019 Poly(ADP-ribose) polymerase 1 (PARP-1) is a multidomain multifunctional nuclear enzyme involved in the regulation of the chromatin structure and transcription.
Ampofo, Michelle +13 more
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PLoS Pathogens, 2010 Candida albicans, the major fungal pathogen of humans, causes life-threatening infections in immunocompromised individuals. Due to limited available therapy options, this can frequently lead to therapy failure and emergence of drug resistance. To improve
Elias Epp +10 more
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