Results 111 to 120 of about 77,829 (292)

High-throughput screening assay for PARP-HPF1 interaction inhibitors to affect DNA damage repair

Scientific Reports
ADP-ribosyltransferases PARP1 and PARP2 play a major role in DNA repair mechanism by detecting the DNA damage and inducing poly-ADP-ribosylation dependent chromatin relaxation and recruitment of repair proteins.
Saurabh S. Dhakar, Albert Galera-Prat, Lari Lehtiö   +2 more
doaj   +1 more source

Cloning and characterization of ADP-ribosylation factor 1b from the olive flounder Paralichthys olivaceus

Fisheries and Aquatic Sciences, 2017
Small GTPases are well known as one of the signal transduction factors of immune systems. The ADP-ribosylation factors (ARFs) can be classified into three groups based on the peptide sequence, protein molecular weight, gene structure, and phylogenetic ...
So-Hee Son, Jin-Hyeon Jang, Hyeon-Kyeong Jo, Joon-Ki Chung, Hyung-Ho Lee   +4 more
doaj   +1 more source

Myristoylation of ADP-ribosylation Factor 1 Facilitates Nucleotide Exchange at Physiological Mg Levels (*)

Journal of Biological Chemistry, 1995
Recombinant N-myristoylated bovine ADP-ribosylation factor 1 (myr-rARF1) has been expressed in bacteria and purified to near homogeneity with a high (85%) myristoylation efficiency.
M. Franco, P. Chardin, M. Chabre, S. Paris   +3 more
semanticscholar   +1 more source

Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]

, 1990
Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland, Wenzel-Seifert, Katharina   +1 more
core   +1 more source

Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6

BMC Cell Biology, 2009
Background Peroxisomes execute diverse and vital functions in virtually every eukaryote. New peroxisomes form by budding from pre-existing organelles or de novo by vesiculation of the ER.
Mannaerts Guy P, Van Dijck Patrick, Huybrechts Sofie J, Hongu Tsunaki, Baumgart-Vogt Eveline, Brees Chantal, Anthonio Erin A, Kanaho Yasunori, Van Veldhoven Paul P, Fransen Marc   +9 more
doaj   +1 more source

Regulation of GRP1-catalyzed ADP Ribosylation Factor Guanine Nucleotide Exchange by Phosphatidylinositol 3,4,5-Trisphosphate*

Journal of Biological Chemistry, 1998
Cellular levels of phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) are rapidly elevated in response to activation of growth factor receptor tyrosine kinases.
J. Klarlund, L. Rameh, L. Cantley, J. Buxton, J. Holik, Christoper Sakelis, V. Patki, S. Corvera, M. Czech   +8 more
semanticscholar   +1 more source

β-Arrestin-mediated ADP-ribosylation Factor 6 Activation and β2-Adrenergic Receptor Endocytosis*

Journal of Biological Chemistry, 2001
β-Arrestins are multifunctional adaptor proteins known to regulate internalization of agonist-stimulated G protein-coupled receptors by linking them to endocytic proteins such as clathrin and AP-2. Here we describe a previously unappreciated mechanism by
A. Claing, Wei Chen, W. Miller, N. Vitale, J. Moss, R. Premont, R. Lefkowitz   +6 more
semanticscholar   +1 more source

Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]

, 2009
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo, Jae-Hyun Park, Jung-Won Kim, Meng-Lay Lin, Miki Akiyama, Tatsuhiko Tsunoda, Tomomi Ueki, Toshihiko Nishidate, Toyomasa Katagiri, Yataro Daigo, Yusuke Nakamura   +10 more
core   +2 more sources

System-Wide Characterization of MoArf GTPase Family Proteins and Adaptor Protein MoGga1 Involved in the Development and Pathogenicity of Magnaporthe oryzae

mBio, 2019
ADP ribosylation factor (Arf) small GTPase family members are involved in vesicle trafficking and organelle maintenance in organisms ranging from Saccharomyces cerevisiae to humans.
Shengpei Zhang, Lina Yang, Lianwei Li, Kaili Zhong, Wenhao Wang, Muxing Liu, Ying Li, Xinyu Liu, Rui Yu, Jialiang He, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang   +13 more
doaj   +1 more source

Type I Phosphatidylinositol 4-Phosphate 5-Kinase Directly Interacts with ADP-ribosylation Factor 1 and Is Responsible for Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Golgi Compartment*

Journal of Biological Chemistry, 2000
Phosphatidylinositol (PtdIns) 4,5-bisphosphate is involved in many aspects of membrane traffic, but the regulation of its synthesis is only partially understood.
David H. Jones, James B. Morris, C. Morgan, Hisatake Kondo, R. Irvine, S. Cockcroft   +5 more
semanticscholar   +1 more source