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Molecular Characterization of ADP-Ribosylation Factors
1993Cholera toxin (CT) is largely responsible for the pathogenesis of cholera, a devastating diarrheal disease characterized by marked abnormalities in fluid and electrolyte flux (Carpenter 1980; Finkelstein 1973; Kelly 1986). The toxin, a product of Vibrio cholerae, is an oligomeric protein composed of one A subunit (CTA) of about 29kDa and five B ...
J. Moss, M. Vaughan
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ADP-ribosylation Factors Protein Activators of Cholera Toxin
1993Publisher Summary The toxins alter the activity of the guanine nucleotide-binding proteins (G proteins) by catalyzing the transfer of the ADP-ribose moiety of NAD to a critical amino acid in the a subunit. This ADP-ribosylation reaction results in either activation (e.g., cholera toxin, E.
J, Moss, M, Vaughan
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ADP-ribosylation factors (Arfs)
1999Abstract AP180 is an abundant neurone-specific clathrin-associated phosphoprotein, which supports in vitro the assembly of clathrin triskelia into a homogeneous population of cage-like structures. This function appears to be regulated by inositol polyphosphates. Proteins related to AP180 are also expressed in non-neuronal cells.
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ADP-Ribosylation Factor-1 Is Sensitive to N-Ethylmaleimide
Journal of Biochemistry, 1998The treatment of normal rat kidney cells with N-ethylmaleimide caused the release of beta-COP, a component of coatomer, from the Golgi apparatus without causing disassembly of the organelle. The release of beta-COP, which was not due to depolymerization of microtubules, was markedly blocked by the activation of GTP-binding proteins by aluminum fluoride
T, Yamaguchi +5 more
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Archaebacterial elongation factor is ADP-ribosylated by diphtheria toxin
Nature, 1980Archaebacteria have been defined as a 'third primary kingdom' of cells in addition to the urkaryotes and the eubacteria. While the latter two correspond approximately to the conventional categories eukaryotes and prokaryotes respectively, the Archaebacteria have up to now comprised four groups of microorganisms: the methanogenic bacteria, the extremely
M, Kessel, F, Klink
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Insulin and epidermal growth factor stimulate poly ADP-ribosylation
Biochemical and Biophysical Research Communications, 1981Abstract Treatment of contact-inhibited BALBc 3T3 fibroblasts with insulin or epidermal growth factor elicited a considerable increase in the capacity of poly (ADP-ribose) synthesis. Stimulation of the poly ADP-ribosylation was observed after long-term hormone treatment (18 hours) but not after short-term treatment (1 hour) and it appeared to ...
Shimizu, Y, Shimizu, N
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Activation of Toxin ADP-Ribosyltransferases by the Family of ADP-Ribosylation Factors
1997ADP-ribosylation factors or ARFs are 20-kDa guanine nucleotide-binding proteins, initially identified as stimulators of cholera toxin-catalyzed ADP-ribosylation of Gs alpha. We now know that ARFs play a critical role in many vesicular trafficking events and ARF activation of a membrane-associated phospholipase D (PLD) has been recognized. ARF is active
M, Vaughan, J, Moss
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The Biology of ADP-Ribosylation Factors
1993Adenosine diphosphate (ADP) ribosylation factor (ARF) was originally defined as an activity required for the efficient activation of the purified, stimulatory, regulatory component of adenylyl cyclase, Gs, by cholera toxin (Schleifer et al. 1982; Kahn 1989, 1991).
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
ADP-ribosylation factor domain protein 1
AfCS-Nature Molecule Pages, 2011Venkateswarlu Kanamarlapudi +1 more
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