Results 31 to 40 of about 8,116 (160)

Emerging key roles for P2X receptors in the kidney [PDF]

, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E., Peppiatt-Wildman, Claire M., Schwiebert, E. M., Wildman, Scott S.P.   +3 more
core   +2 more sources

Extrarenal manifestations of ADPKD

Kidney International, 1997
A 47-year-old woman was evaluated in the Nephrology Clinic at New England Medical Center for autosomal dominant polycystic kidney disease (ADPKD). She had undergone abdominal and pelvic noncontrast computed tomographic scans for the evaluation of dyspareunia and stress incontinence.
openaire   +3 more sources

Cardiovascular Manifestations and Management in ADPKD

Kidney International Reports, 2023
Cardiovascular disease (CVD) is the major cause of mortality in autosomal dominant polycystic kidney disease (ADPKD) and contributes to significant burden of disease. The manifestations are varied, including left ventricular hypertrophy (LVH), intracranial aneurysms (ICAs), valvular heart disease, and cardiomyopathies; however, the most common ...
Sagar, Priyanka S., Rangan, Gopala K.
openaire   +2 more sources

Renal Volume in ADPKD Patient Evaluation [PDF]

International Journal of Nephrology, 2020
The clinical manifestations of ADPKD are related to the growth of renal cysts. Renal volume has been recognised as the biomarker that is able to identify those patients at risk of complications (hypertension and haematuria) and at risk of progression to End Stage Renal Disease (ESRD).
M. Galliani, E. Vitaliano, S. Chicca, L. Calvaruso, L. Di Lullo, F. Iorio, M. E. Tosti, A. Paone   +7 more
openaire   +4 more sources

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex [PDF]

, 2009
Mutations in PKD1 and TRPP2 account for nearly all cases of autosomal dominant polycystic kidney disease (ADPKD). These 2 proteins form a receptor/ion channel complex on the cell surface. Using a combination of biochemistry, crystallography, and a single-
Buraei, Z., Chen, X.Z., Isacoff, E.Y., Li, M.H., Ong, A.C.M., Tong, L., Ulbrich, M., Yang, J., Yu, Y.   +8 more
core   +3 more sources

Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease. [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is a widespread genetic disease that leads to renal failure in the majority of patients. The very first pharmacological treatment, tolvaptan, received Food and Drug Administration approval in 2018 ...
Bourgeois, Bryan C, Kruger, Samantha L, Shillingford, Jonathan M, Torres, Jacob, Weimbs, Thomas   +4 more
core   +1 more source

Assessment of GFR by four methods in adults in Ashanti, Ghana: the need for an eGFR equation for lean African populations [PDF]

, 2010
Background. Equations for estimating glomerular filtration rate (GFR) have not been validated in Sub-Saharan African populations, and data on GFR are few. Methods.
Antwi, S, Banerjee, D, Boa, FG, Cappuccio, FP, Eastwood, JB, Emmett, L, Kerry, SM, Micah, FB, Miller, MA, Plange-Rhule, J   +9 more
core   +5 more sources

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

International consensus statement on the diagnosis and management of autosomal dominant polycystic kidney disease in children and young people [PDF]

, 2019
These recommendations were systematically developed on behalf of the Network for Early Onset Cystic Kidney Disease (NEOCYST) by an international group of experts in autosomal dominant polycystic kidney disease (ADPKD) from paediatric and adult nephrology,
Bergmann, Carsten, Bockenhauer, Detlef, Breysem, Luc, Cadnapaphornchai, Melissa A, Cetiner, Metin, Dudley, Jan, Emma, Francesco, Gimpel, Charlotte, Harris, Peter C, Harris, Tess, Konrad, Martin, König, Jens, Liebau, Max C, Marlais, Matko, Mekahli, Djalila, Metcalfe, Alison, Oh, Jun, Perrone, Ronald D, Schaefer, Franz, Sinha, Manish D, Titieni, Andrea, Torra, Roser, Weber, Stefanie, Winyard, Paul JD   +23 more
core   +2 more sources

LRP5 variants may contribute to ADPKD [PDF]

European Journal of Human Genetics, 2015
Mutations in Polycystic Kidney Disease proteins (PKD1 or PKD2) are causative for autosomal dominant polycystic kidney disease (ADPKD). However, a small subset of ADPKD probands do not harbor a mutation in any of the known genes. Low density lipoprotein Receptor-related Protein 5 (LRP5) was recently associated with hepatic cystogenesis in isolated ...
Carsten Bergmann, Alexander Hoischen, Joris A. Veltman, Joris A. Veltman, Joost P.H. Drenth, Martijn H. Breuning, Christian Gilissen, Hanka Venselaar, Dorien J.M. Peters, Rene H. M. te Morsche, Soufi Mehdi, Monique Losekoot, Wybrich R Cnossen   +12 more
openaire   +5 more sources