p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels. [PDF]
, 2007 BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease with few treatment options other than renal replacement therapy. p21, a cyclin kinase inhibitor which has pleiotropic effects on the cell cycle, in many cases acts
Anderson, Sharon +6 more
core +3 more sources
Targeting Cyst Initiation in ADPKD [PDF]
Journal of the American Society of Nephrology, 2009 With approximately 12.5 million people worldwide affected by autosomal dominant polycystic kidney disease (ADPKD), one hopes we are now at the beginning of multiple therapeutic breakthroughs. ADPKD is a hereditary disorder caused by a genetic defect in either polycystin-1 ( PKD1 ; PC1) or polycystin-2 ( PKD2 ; PC2) that leads to progressive kidney cyst
Stephanie J, Leuenroth, Craig M, Crews
openaire +2 more sources
Magnetic resonance imaging 3t and total fibrotic volume in autosomal dominant polycystic kidney disease [PDF]
, 2018 INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal hereditary disorder. Several authors have attempted to identify a kidney damage marker for predicting the prognosis and the effectiveness of therapy in ADPKD ...
Ciccariello, Mauro +9 more
core +1 more source
Kidney Diseases, 2020 Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, with a prevalence of 1/2,500–1/1,000, and it affects 1.25 million people in China.
Chang-Lin Mei +18 more
doaj +1 more source
Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury [PDF]
, 2009 Autosomal dominant polycystic kidney disease (ADPKD) results from mutations in either PKD1 or PKD2 and accounts for 10% of all patients on renal replacement therapy. The kidney disease phenotype is primarily characterized by cyst formation, but there are
Haylor, J.L. +4 more
core +2 more sources
Characterization of Primary Cilia in Osteoblasts Isolated From Patients With ADPKD and CKD
JBMR Plus, 2021 Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of chronic kidney disease (CKD) and leads to a specific type of bone disease.
Renata C Pereira +6 more
doaj +1 more source
Chronic subdural haematoma and arachnoid cyst in autosomal dominant polycystic kidney disease (ADPKD) [PDF]
, 2005 We present the unusual association between chronic subdural haematoma (CSDH), intracranial arachnoid cyst and autosomal dominant polycystic kidney disease (ADPKD) in a 27-year-old man. CSDH is a documented complication of intracranial arachnoid cyst, the
Leung, GKK, Yiu, WF
core +1 more source
Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression. [PDF]
, 2015 BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by numerous fluid-filled cysts that frequently result in end-stage renal disease. While promising treatment options are in advanced clinical development,
Bernet, F. +11 more
core +2 more sources
TAMEing ADPKD with metformin: safe and effective?
Kidney International, 2021 The biguanide metformin has been safely and widely used in the treatment of type 2 diabetes mellitus for decades. Preclinical studies have suggested that it may have a role in slowing disease progression in autosomal dominant polycystic kidney disease. In this issue, Perrone et al.
Ong, A.C.M., Gansevoort, R.T.
openaire +3 more sources
Autosomal dominant polycystic kidney disease and coronary artery dissection or aneurysm: A systematic review [PDF]
, 2016 Importance Autosomal dominant polycystic kidney disease (ADPKD) has been associated with cardiovascular abnormalities such as intracranial and aortic aneurysms.
Lopes, JA, Neves, JB, Rodrigues, FB
core +1 more source