Results 41 to 50 of about 8,116 (160)

Changes in Protein Expression of Renal Drug Transporters and Drug‐Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann, Dorien J. M. Peters, Amin Rostami‐Hodjegan, Patricia Wilson, Jill Norman, Jill Barber, Zubida M. Al‐Majdoub   +6 more
wiley   +1 more source

A model to predict disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD): the ADPKD Outcomes Model. [PDF]

, 2018
Background: Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD); however, the natural course of disease progression is heterogeneous between patients.
Bennett Wilton, Hayley, Cabrera, Maria-Cristina V, McEwan, Phil, O'Reilly, Karl, Ong, Albert CM, Robinson, Paul, Sandford, Richard, Scolari, Francesco, Walz, Gerd, Ørskov, Bjarne   +9 more
core   +5 more sources

Therapeutic advances in ADPKD: the future awaits

Journal of Nephrology, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is a heterogeneous genetic disorder included in ciliopathies, representing the fourth cause of end stage renal disease (ESRD), with an estimated prevalence between 1:1000 and 1:2500. It is mainly caused by mutations in the PKD1 and PKD2 genes encoding for polycystin 1 (PC1) and polycystin 2 (PC2 ...
Capuano I., Buonanno P., Riccio E., Amicone M., Pisani A.   +4 more
openaire   +5 more sources

Gynecological surgery in patients with kidney failure on chronic kidney replacement therapy: A binational data linkage study of morbidity and mortality outcomes

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study evaluates postoperative outcomes of patients with kidney failure on chronic kidney replacement therapy after gynecological surgery. Methods This binational data‐linkage study identified patients with kidney failure via the Australia and New Zealand Dialysis and Transplant Registry who underwent major gynecological ...
Mina Khair, Dharmenaan Palamuthusingam, Carmel M. Hawley, Elaine M. Pascoe, Usama Shahid, David W. Johnson, Magid Fahim   +6 more
wiley   +1 more source

Autosomal dominant polycystic kidney disease and coronary artery dissection or aneurysm: A systematic review [PDF]

, 2016
Importance Autosomal dominant polycystic kidney disease (ADPKD) has been associated with cardiovascular abnormalities such as intracranial and aortic aneurysms.
Lopes, JA, Neves, JB, Rodrigues, FB
core   +1 more source

Posterior Reversible Leukoencephalopathy Syndrome and Disseminated Varicella‐Zoster Virus Infection After Kidney Transplantation

IJU Case Reports, EarlyView.
ABSTRACT Introduction Posterior reversible leukoencephalopathy syndrome (PRES) is a rare but serious complication in kidney transplant recipients, often triggered by calcineurin inhibitors (CNIs) and infections. Case Presentation A 52‐year‐old woman with end‐stage kidney disease underwent cadaveric renal transplantation. Two months post‐transplant, she
Kenji Tsutsui, Shigeaki Nakazawa, Makoto Kinoshita, Yoko Higa, Soichi Matsumura, Shota Fukae, Ryo Tanaka, Norichika Ueda, Yoichi Kakuta, Norio Nonomura   +9 more
wiley   +1 more source

Operative and nonoperative management of acute cholecystitis in patients on chronic kidney replacement therapy

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
Abstract Background Patients with kidney failure receiving chronic kidney replacement therapy (KRT: dialysis or kidney transplantation) have increased risks of postoperative mortality and morbidity. This study assesses the outcomes of acute cholecystitis in patients on chronic KRT who undergo cholecystectomy compared to nonoperative management ...
Dharmenaan Palamuthusingam, Carmel M. Hawley, Elaine M. Pascoe, David Wayne Johnson, Palvannan Sivalingam, Simon T. Wood, Pranavan Palamuthusingam, Matthew D. Jose, Magid Fahim   +8 more
wiley   +1 more source

Index cases of intracranial aneurysms in autosomal dominant polycystic kidney disease: longitudinal experience from a single renal transplantation centre

ANZ Journal of Surgery, EarlyView.
Abstract Background The prevalence of intracranial aneurysms (ICAs) is higher in patients with autosomal dominant polycystic kidney disease (ADPKD) than in the general population. This extrarenal manifestation carries significant mortality and morbidity risks.
Joel Ern Zher Chan, Kate S. Olakkengil, Shantanu Bhattacharjya, Santosh Antony Olakkengil   +3 more
wiley   +1 more source

Hypertension in autosomal dominant polycystic kidney disease: a meta-analysis [PDF]

, 2016
CONTEXT: Autosomal dominant polycystic kidney disease (ADPKD) is a common disorder that can cause hypertension during childhood, but the true prevalence of hypertension during childhood is not known.
Cuthell, O, Dudley, J, Langan, D, Marlais, M, Sinha, MD, Winyard, PJ   +5 more
core   +1 more source

Robot‐assisted vs open kidney transplantation from deceased donors

BJU International, EarlyView.
Objectives To test the hypothesis that the type of surgical approach, robot‐assisted kidney transplantation (RAKT) vs open kidney transplantation (OKT), impacts intra‐operative and postoperative surgical outcomes of patients receiving kidney transplantation from deceased donors.
Luca Afferi, Angelo Territo, Alessio Pecoraro, Lorenzo Masieri, Milla Ortved, Julia Abildgaard Dagnæs‐Hansen, Begonya Etcheverry, Andrea Gallioli, Donato Cannoletta, Joris Vangeneugden, Jeremy Mercier, Thomas Prudhomme, Isacco Donnini, Antonino Vazzana, Malene Rohrsted, Francesc Vigués, Nicolas Doumerc, Karel Decaestecker, Joan Palou, Riccardo Campi, Sergio Serni, Andreas Roder, Alberto Breda   +22 more
wiley   +1 more source