Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein. [PDF]
Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer's disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here, we used
Fong, Lauren K +5 more
core +3 more sources
ADRC in output and error form: connection, equivalence, performance
In this work, we investigate two specific linear ADRC structures, namely output- and error-based. The former is considered a 'standard' version of ADRC, a title obtained primarily thanks to its simplicity and effectiveness, which have spurred its adoption across multiple industries. The latter is found to be especially appealing to practitioners as its
Madonski, Rafal +2 more
openaire +3 more sources
AI‐enabled bumpless transfer control strategy for legged robot with hybrid energy storage system
Abstract Designing Hybrid energy storage system (HESS) for a legged robot is significant to improve the motion performance and energy efficiency of the robot. However, switching between the driving mode and regenerative braking mode in the HESS may generate a torque bump, which has brought significant challenges to the stability of the robot locomotion.
Zhiwu Huang +6 more
wiley +1 more source
Is commercial/private sector access to administrative data inevitable?
Background Currently in the UK, access to publicly collected administrative data for use in research, is only available to accredited researchers. However, administrative data may be of interest to commercial or private sector organisations, some of whom
Carol Porteous
doaj +1 more source
Raising Expectations: A State Scorecard on Long-Term Services and Supports for Older Adults, People With Physical Disabilities, and Family Caregivers [PDF]
Ranks long-term services and supports systems for affordability and access, choice of setting and provider, quality of life and care, and family caregivers support.
Ari Houser +3 more
core
We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour +10 more
wiley +1 more source
Active Disturbance Rejection Control for Piezoelectric Smart Structures: A Review
The piezoelectric smart structures, which can be labeled as the cream of the crop of smart structures without overstatement, are strongly impacted by a large number of uncertainties and disturbances during operation.
Juan Li +4 more
doaj +1 more source
ABSTRACT Background In 2023 and 2024, research into semaglutide (SEMA), an antiobesity and antidiabetic medication, indicated potential benefits beyond its approved uses, particularly in preventing Alzheimer's disease (AD). This highlights the link between obesity and AD development.
Amene Saghazadeh +14 more
wiley +1 more source
Design of MMC-STATCOM controller based on ADRC technology
The design of MMC-STATCOM controller based on auto disturbance rejection technology is studied. Based on the ADRC, the active disturbance rejection controller is designed for the active and reactive current decoupling tracking.
Chen Hui +3 more
doaj +1 more source
Ship Dynamic Positioning Control Based on Active Disturbance Rejection Control
Nowadays, Dynamic Positioning (DP) is applied to various tasks such as subsea pipeline laying and the requirements for the positioning performance in marine operations are higher and higher.
Hongliang Li +5 more
doaj +1 more source

