Results 61 to 70 of about 577,986 (368)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs

Frontiers in Endocrinology, 2019
Neonatal lambs, as other neonates, have physiologically a very low plasma melatonin concentration throughout 24 h. Previously, we found that melatonin given to neonates daily for 5 days decreased heart weight and changed plasma cortisol and gene ...
Felipe A. Beñaldo, Aníbal J. Llanos, Aníbal J. Llanos, Claudio Araya-Quijada, Auristela Rojas, Alejandro Gonzalez-Candia, Emilio A. Herrera, Emilio A. Herrera, Germán Ebensperger, Gertrudis Cabello, Guillermo J. Valenzuela, María Serón-Ferré   +11 more
doaj   +1 more source

Post-Mortem Immunohistochemical Evidence of β2-Adrenergic Receptor Expression in the Adrenal Gland [PDF]

, 2019
The evidence from post-mortem biochemical studies conducted on cortisol and catecholamines suggest that analysis of the adrenal gland could provide useful information about its role in human pathophysiology and the stress response.
Alibrandi A., Asmundo A., Baldino G., Cardia L., Macaione V., Malta C., Micali A., Minutoli L., Mondello C., Puzzolo D., Ventura Spagnolo E.   +10 more
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Detección precoz de trastornos endocrinológicos

Revista Médica Clínica Las Condes, 2010
Se revisan los trastornos más comunes del sistema endocrino que se detectan en la consulta no especializada. Se hace énfasis en: a) Trastornos tiroideos tales como hipo o hipertiroidismo, nódulos de la tiroides y la importancia de la enfermedad de la ...
M. Patricio Trincado, Dr., B. Carolina Letelier, Dra.   +1 more
doaj   +1 more source

Steroid stewardship

Indian Journal of Endocrinology and Metabolism, 2022
Steroid stewardship is the systematic effort to prescribe and monitor glucocorticoids in a rational manner, while balancing benefit and potential risk, in patients who require this therapy.
Sanjay Kalra, Ashok Kumar, Rakesh Sahay
doaj   +1 more source

Deep Multi-Scale Resemblance Network for the Sub-class Differentiation of Adrenal Masses on Computed Tomography Images [PDF]

arXiv, 2020
The accurate classification of mass lesions in the adrenal glands (adrenal masses), detected with computed tomography (CT), is important for diagnosis and patient management. Adrenal masses can be benign or malignant and benign masses have varying prevalence.
arxiv  

Stability and Hopf bifurcation analysis of a four-dimensional hypothalamic-pituitary-adrenal axis model with distributed delays [PDF]

, 2017
A four-dimensional mathematical model of the hypothalamus-pituitary-adrenal (HPA) axis is investigated, incorporating the influence of the GR concentration and general feedback functions. The inclusion of distributed time delays provides a more realistic modeling approach, since the whole past history of the variables is taken into account.
arxiv   +1 more source

Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia [PDF]

, 2006
Objective: Familial glucocorticoid deficiency type I (FGD1) is a rare form of primary adrenal insufficiency resulting from recessive mutations in the ACTH receptor (MC2R, MC2R).
Achermann, JC, Al-Ali, M, Alzyoud, M, Brain, CE, Clark, AJ, Dattani, MT, Hindmarsh, PC, Lin, L, Metherell, LA   +8 more
core   +2 more sources

Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia [PDF]

Endocrinology and Metabolism Clinics of North America, 2015
Adrenal steroidogenesis is a dynamic process, reliant on de novo synthesis from cholesterol, under the stimulation of ACTH and other regulators. The syntheses of mineralocorticoids (primarily aldosterone), glucocorticoids (primarily cortisol), and adrenal androgens (primarily dehydroepiandrosterone and its sulfate) occur in separate adrenal cortical ...
Richard J. Auchus, Adina F. Turcu
openaire   +3 more sources