Results 101 to 110 of about 63,701 (227)

The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

MedComm, Volume 6, Issue 6, June 2025.
Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu, Shiyuan Huang, Li Peng, Li Yang, Guosong Zhang, Tao Liu, Fang Yan, Xi Peng   +7 more
wiley   +1 more source

Profile of Rat Adrenal microRNAs Induced by Gonadectomy and Testosterone or Estradiol Replacement. [PDF]

Int J Mol Sci
Jopek K, Tyczewska M, Blatkiewicz M, Olechnowicz A, Szyszka M, Stelcer E, Ciesiółka S, Jopek M, Malendowicz LK, Ruciński M.   +9 more
europepmc   +1 more source

Isolation and radioimmunoassay of thyroxine-binding globulin (TGB) [PDF]

, 1974
Erhardt, F., Horn, K., Livesey, P. G., Scriba, Peter Christian   +3 more
core   +1 more source

Critical Role of Skin in Pathogenesis: Bidirectional Crosstalk Between Skin and Multiple Organs

MedComm – Future Medicine, Volume 4, Issue 2, June 2025.
The skin functions as both a protective barrier and an autonomous immune organ, maintaining dynamic interactions with internal organs. This review analyzes skin‐organ crosstalk mechanisms, highlighting key cytokines (particularly IL‐17A) and microbial metabolites that mediate interorgan communication.
Wende Deng, Junyi Liu, Changheng Tang, Zhenghao Li, Ying Qiu, Han Zhou, Lanxuan Yang, Ting Li   +7 more
wiley   +1 more source

THE HORMONES OF THE ADRENAL CORTEX

Cold Spring Harbor Symposia on Quantitative Biology, 1937
openaire   +2 more sources

ACTH bioassay with isolated rat adrenal cells: ACTH activity of the porcins lipotropic peptide B [PDF]

, 1974
Baur, X., Marschner, I., Müller, O. A., Schwandt, P., Scriba, Peter Christian, Weisweiler, P.   +5 more
core   +1 more source

The Oxytocin Neurons in the Paraventricular Nucleus Are Essential for Chronic Sleep Deprivation‐Mediated Anxiety‐Related Behaviors

CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Chronic sleep deprivation (cSD) promoted anxiety‐related behaviors mainly through inhibiting AMPAR‐mediated postsynaptic excitability of PVNOXT neurons. LTF simulation of PVNOXT neurons could increase anxiety‐like behaviors by inhibiting the PVNOXT‐mPFC pathway. PVNOXT‐mediated inhibitory transmission of the mPFC was enhanced by HSF following cSD.
Yuxin Wang, Yifei Zhang, Yanchao Liu, Zhendong Xu, Jiyan Zhang, Like Wang, Yufeng Cang, Junbin Xin, Fuyu Han, Zhouhua Li, Chuanwei Hu, Xiangjie Kong, Yuchen Deng, Li Zhang, Hairong Wang, Haibo Xu, Ming Chen, Linlin Bi   +17 more
wiley   +1 more source

NR5A1 and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms. [PDF]

Reprod Med Biol
Inoue M, Miyabayashi K, Shima Y.
europepmc   +1 more source

Daytime sleepiness and BMI exhibit gender and age differences in patients with central disorders of hypersomnolence

Journal of Sleep Research, Volume 34, Issue 3, June 2025.
In a cohort of central disorders of hypersomnolence, specifically women with idiopathic hypersomnia showed a marked subjective daytime sleepiness peak in the early 30s, while the body mass index only started to rise at that age. Better understanding of the pathophysiology of these gender and age‐specific characteristics will support tailored ...
Laura Ferrazzini, Markus Schmidt, Zhongxing Zhang, Ramin Khatami, Yves Dauvilliers, Lucie Barateau, Geert Mayer, Fabio Pizza, Giuseppe Plazzi, Jari K. Gool, Rolf Fronczek, Gert Jan Lammers, Rafael del Rio‐Villegas, Rosa Peraita‐Adrados, Markku Partinen, Sebastiaan Overeem, Karel Sonka, Joan Santamaria, Raphael Heinzer, Francesca Canellas, Antonio Martins da Silva, Birgit Högl, Christian Veauthier, Aleksandra Wierzbicka, Eva Feketeova, Jitka Buskova, Michel Lecendreux, Silvia Miano, Ulf Kallweit, Anna Heidbreder, Claudio L. A. Bassetti, Julia van der Meer   +31 more
wiley   +1 more source

Salivary hormones in depression: the future in diagnosis and treatment. [PDF]

Ann Gen Psychiatry
Harsanyi S, Kupcova I, Csobonyeiova M, Klein M.   +3 more
europepmc   +1 more source