Results 71 to 80 of about 748,383 (382)

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Electron-microscopic features of changes in the adrenal and thyroid glands in chronic hypoxia

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021
The aim of the study was to study the characteristic features of ultrastructural changes in the cellular and extracellular matrix of the adrenal and thyroid glands in chronic hypoxia.Materials and methods. The study used the thyroid and adrenal glands of
S. M. Yagubova
doaj   +1 more source

New directions for the treatment of adrenal insufficiency [PDF]

, 2015
The following funding bodies supported this work: Biotechnology and Biological Sciences Research Council (BBSRC BB/L00267/1, to LG), Rosetrees Trust (to LG), Barts and The London Charity (417/2235, to LG), EU COFUND (PCOFUND-GA-2013-608765, to LG and GRB)
Allen, Allende, Badylak, Bancos, Berkes, Birke, Buaas, Chamoux, Chamoux, Clipsham, Cogger, Cox, Crawford, Drucker, Dubernard, El-Khairi, Else, Faulk, Fayard, Franksson, Freedman, Gallo-Payet, Gondo, Gondo, Grodstein, Guasti, Guasti, Hardy, Hardy, Hardy, Hardy, Hatano, Huang, Huang, Ibbertson, Jadhav, Kearns, Kim, King, Laufer, Ludwig, Luo, Mazilu, Parker, Sancho-Martinez, Schimmer, Schnabel, Sonoyama, Takahashi, Tanaka, Teebken, Thomas, Thomas, Thomas, Thomas, Thomas, Val, Val, Vierbuchen, Vouillarmet, Walczak, Walczak, Wei, Wilhelm, Wong, Yazawa, Yazawa, Yazawa, Yazawa, Zupekan   +69 more
core   +2 more sources

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Acoustic radiation force impulse (ARFI) elastography of adrenal glands in healthy adult dogs

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
To describe the ARFI elastography in the evaluation of the adrenal glands in adult dogs, to evaluate the stiffness of adrenal parenchyma and to determine the qualitative and quantitative standards of the ARFI technique, which have not yet been described ...
S. Fernandez, M.A.R. Feliciano, S. Borin-Crivellenti, L.Z. Crivellenti, M.C. Maronezi, A.P.R. Simões, P.D.A. Silva, R.R. Uscategui, N.R.N. Cruz, A.E. Santana, W.R.R. Vicente   +10 more
doaj   +1 more source

Primary hyperaldosteronism: challenges in subtype classification

BMC Research Notes, 2012
Background Primary hyperaldosteronism (PA) is a serious and potentially debilitating disease. Detailed guidelines have been written to guide endocrinologists in establishing the diagnosis of PA as well as in subtype classification of PA. The objective of
Layden Brian T, Hahr Allison J, Elaraj Dina M   +2 more
doaj   +1 more source

Adrenal insufficiency due to bilateral adrenal metastases - A systematic review and meta-analysis [PDF]

, 2019
Objective: Bilateral adrenal metastases may cause adrenal insufficiency (AI) but it is unclear if screening for AI in patients with bilateral adrenal metastases is justified, despite the potential for adrenal crises. Method: A search using PubMed/Medline,
Falhammar, Henrik, Rushworth, R Louise, Tallis, Philippa H, Torpy, David J   +3 more
core   +1 more source

The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders [PDF]

, 2020
Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity.
Clark, Ashley K, Saric-Bosanac, Suzana, Shi, Vivian Y, Sivamani, Raja K   +3 more
core  

Sequential Metabolism of 7-Dehydrocholesterol to Steroidal 5,7-Dienes in Adrenal Glands and Its Biological Implication in the Skin

PLoS ONE, 2009
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC metabolism by adrenal glands ex vivo.
A. Slominski, M. Żmijewski, I. Semak, T. Sweatman, Z. Janjetović, Wei Li, J. Zjawiony, R. Tuckey   +7 more
semanticscholar   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source