Results 71 to 80 of about 477,806 (337)
Advanced Science, EarlyView.Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu +17 more
wiley +1 more source
A rare occurrence of central precocious puberty in adrenal hypoplasia congenita
Sri Lanka Journal of Medicine, 2020 AHC (X-linked adrenal hypoplasia congenita) is a rare cause of adrenal insufficiency due to mutations in the DAX1 gene. It traditionally causes hypogonadotropic hypogonadism.
Rajesh Joshi, Karthik Shroff
doaj +1 more source
Adrenal Insufficiency and Glucocorticoid Use During the COVID-19 Pandemic
Clinics, 2020 The coronavirus disease 2019 (COVID-19) is an emerging pandemic challenge. Acute respiratory distress syndrome (ARDS) in COVID-19 is characterized by a severe cytokine storm.
M. Almeida, B. Mendonca
semanticscholar +1 more source
Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation
Advanced Science, EarlyView.Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li +18 more
wiley +1 more source
Current Screening Strategies for the Diagnosis of Adrenal Insufficiency in Children
Pediatric Health, Medicine and Therapeutics, 2023 Sasigarn A Bowden Division of Endocrinology, Department of Pediatrics, Nationwide Children’s Hospital/The Ohio State University College of Medicine, Columbus, OH, USACorrespondence: Sasigarn A Bowden, Nationwide Children’s Hospital, Division of ...
Bowden SA
doaj
Infant With Adrenal Insufficiency and Shock
MedEdPORTAL, 2015 Introduction Adrenal insufficiency is an uncommon presentation to the emergency department (ED) but can be the cause of morbidity and mortality if not recognized and treated appropriately.
Kelly Levasseur, Katherine Cashen
doaj +1 more source
The diagnosis of adrenal insufficiency in the critically ill patient: does it really matter? [PDF]
, 2006 The definition of what constitutes a \u27normal\u27 adrenal response to critical illness is unclear. Consequently, published studies have used a variety of biochemical criteria to define \u27adrenal insufficiency\u27.
Marik, Paul E
core +4 more sources
Advanced Science, EarlyView.Spirulina‐nano system facilitates the formation of drug coating on spirulina's surface through electrostatic adsorption. It targets intestinal villi effectively and overcomes the pharmacokinetic complications of IBS‐D. This system successfully carried out the treatment of multiple symptoms, including diarrhea, visceral hypersensitivity, mental symptoms,
Jiahui Ye +7 more
wiley +1 more source
Diagnosis and treatment of canine hypoadrenocorticism [PDF]
, 2018 Canine hypoadrenocorticism (Addison’s disease), the ‘great pretender’ of internal medicine, is a disease that should be frequently considered as a differential diagnosis of several clinical presentations, albeit it is less commonly the actual cause of ...
Gunn, Eilidh +2 more
core +1 more source
Advanced Science, EarlyView.This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li +22 more
wiley +1 more source