Results 141 to 150 of about 186,020 (321)

Associations among sleep quality, cognitive processing therapy, and posttraumatic stress disorder symptoms in a primary care setting

open access: yesJournal of Traumatic Stress, EarlyView.
Abstract Evidence describing the association between sleep quality and trauma‐focused therapy is mixed. This secondary analysis of a primary care sample examined whether (a) baseline sleep quality moderated posttraumatic stress disorder (PTSD) symptom severity over time across groups receiving different doses of cognitive processing therapy (CPT) and ...
Nicola Park   +7 more
wiley   +1 more source

Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 83-97, January 2023., 2023
Abstract Exposure to fine particulate matter (PM2.5) from incomplete fossil fuel combustion (coal, oil, gas and diesel) has been linked to increased morbidity and mortality due to metabolic diseases. PM2.5 exaggerate adipose inflammation and insulin resistance in mice with diet‐induced obesity.
Bendik C. Brinchmann   +9 more
wiley   +1 more source

Exercise training to increase tumour natural killer‐cell infiltration in men with localised prostate cancer: a randomised controlled trial

open access: yesBJU International, Volume 131, Issue 1, Page 116-124, January 2023., 2023
Objectives To explore the effects of preoperative high‐intensity interval training (HIIT) compared to usual care on tumour natural killer (NK)‐cell infiltration in men with localised prostate cancer (PCa), as NK‐cell infiltration has been proposed as one of the key mechanisms whereby exercise can modulate human tumours.
Sissal Sigmundsdóttir Djurhuus   +12 more
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

open access: yesBritish Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi   +6 more
wiley   +1 more source

Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform

open access: yesMovement Disorders, EarlyView.
Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles   +29 more
wiley   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni   +5 more
wiley   +1 more source

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