Results 161 to 170 of about 200,795 (317)

Figure S7 from Comparative Single-Cell Transcriptomics of Human Neuroblastoma and Preclinical Models Reveals Conservation of an Adrenergic Cell State [PDF]

Bethel Tesfai Embaie, Hirak Sarkar, Adele M. Alchahin, Jörg Otte, Thale Kristin Olsen, Conny Tümmler, Polina Kameneva, Artem V. Artemov, Natalia Akkuratova, Igor Adameyko, Jan‐Bernd Stukenborg, Malin Wickström, Per Kogner, John Inge Johnsen, Shenglin Mei, Peter V. Kharchenko, Ninib Baryawno   +16 more
openalex   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

The effect of sex on the isolated and combined α- and β-adrenergic control of blood flow during handgrip in adults at high altitude: An exploratory study. [PDF]

Physiol Rep
Maier LE, Vanden Berg ER, Simpson L, Ewalts M, Foster K, Baylis J, Gasho C, Macleod D, van Diepen S, Anholm J, Lawley J, Ainslie PN, Gibbons TD, Stembridge M, Moore J, Steinback CD.   +15 more
europepmc   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Could Esmolol/Landiolol Infusion During Pulsed Field Ablation of Atrial Fibrillation Have Averted Takotsubo Syndrome? [PDF]

JACC Case Rep
Madias JE.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Vasopressor Strategy in Pediatric Sepsis: A Clinical Pharmacology Perspective. [PDF]

J Pediatr Pharmacol Ther
Green DJ, Watt KM.
europepmc   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Association between Depression, Pressure Pain Sensitivity, Stress and Autonomous Nervous System Function in Stable Ischemic Heart Disease: Impact of Beta-Adrenergic Receptor Blockade

, 2016
Søren Ballegaard, Natasha C. Bergmann, Benny Karpatschof, Jesper Kristiansen, Finn Gyntelberg, Lars Arendt‐Nielsen, Per Bech, Åke Hjalmarson, Jens Faber   +8 more
openalex   +2 more sources

Diverse tissue expression of rat alpha 2-adrenergic receptor genes. [PDF]

, 1993
Diane E. Handy, C S Flordellis, Natalia Bogdanova, Margaret Bresnahan, Haralambos Gavras   +4 more
openalex   +1 more source