Results 161 to 170 of about 41,637 (221)
Management of Traumatic Brain Injury Sequelae With Alpha-2 Adrenergic Receptor Agonists
Journal of Head Trauma RehabilitationObjective: To describe clinical uses of the class of alpha-2 receptor agonist medications in the treatment of traumatic brain injury sequelae. Clinicians treating patients with traumatic brain injuries (TBI) will often see patients who have been prescribed alpha-2 agonists or may consider initiating use.
Jamie L. Ott, Thomas K. Watanabe
openaire +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Different Affinities of α2-Agonists for Imidazoline and α2-Adrenergic Receptors
American Journal of Hypertension, 1989It has recently been shown that imidazoline alpha 2-adrenergic agonists, such as clonidine and UK 14,304, selectively bind to both alpha 2- and imidazoline receptors in basolateral membranes from rabbit renal proximal tubule. In order to define the relative affinity of three antihypertensive alpha 2-agonists for the two classes of receptors, we ...
René-Alexandre Podevin +4 more
openaire +3 more sources
Pharmacological screening of a new alpha-2 adrenergic receptor agonist, mafedine, in zebrafish
Neuroscience Letters, 2019Pharmacological agents acting at alpha-2 adrenergic receptors are widely used in physiology and neuroscience research. Mounting evidence of their potential utility in clinical and experimental psychopharmacology, necessitates new models and novel model organisms for their screening. Here, we characterize behavioral effects of mafedine (6-oxo-1-phenyl-2-
Yuriy I. Sysoev +5 more
openaire +3 more sources
Alpha-2 Adrenergic Receptor Agonists
2014Alpha-2 adrenergic receptor agonists include clonidine, guanfacine, guanabenz, methyldopa, rilmenidine, and moxonidine. These are centrally active antihypertensive drugs.
Esen Özkaya +1 more
openaire +2 more sources
Peripheral nociceptive effects of α2-adrenergic receptor agonists in the rat
Neuroscience, 1995We have previously shown that norepinephrine can produce hyperalgesia via an alpha 2-adrenergic receptor mechanism. The alpha 2-adrenergic receptor agonist clonidine has, however, also been shown to produce peripheral analgesia. In view of the multiple alpha 2-subtypes currently known (i.e.
Paul G. Green +3 more
openaire +3 more sources
[Adrenergic receptor and alpha 2 agonist--2: Structure-function relationship of adrenoceptors].
Masui. The Japanese journal of anesthesiology, 1997 Recombinant DNA experiments using chimeric receptors containing portions of alpha 2 and beta 2 adrenoceptors demonstrated structure-function relationships of adrenoceptors. The seventh transmembrane domain determines the subtype ligand binding specificity between alpha 2 and beta 2 adrenoceptors.
Toshiki Mizobe
openaire +2 more sources
Molecular Pharmacology, 1990
Unlabeled p-iodoclonidine was efficacious in attenuating forskolin-stimulated cAMP accumulation in SK-N-SH neuroblastoma cells. Maximal attenuation was 76 +/- 3%, with an EC50 of 347 +/- 60 nM. Comparable values of epinephrine were 72 +/- 3% and 122 +/- 22 nM. Responses to both agonists were abolished by 10 microM phentolamine.
B M, Baron, B W, Siegel
openaire +2 more sources
Unlabeled p-iodoclonidine was efficacious in attenuating forskolin-stimulated cAMP accumulation in SK-N-SH neuroblastoma cells. Maximal attenuation was 76 +/- 3%, with an EC50 of 347 +/- 60 nM. Comparable values of epinephrine were 72 +/- 3% and 122 +/- 22 nM. Responses to both agonists were abolished by 10 microM phentolamine.
B M, Baron, B W, Siegel
openaire +2 more sources
Cross‐dependence to opioid and α 2 ‐adrenergic receptor agonists in NG108‐15 cells
The FASEB Journal, 1988Clonidine, a partial alpha 2-agonist, has been used empirically to alleviate opiate withdrawal symptoms, but the mechanism of its effects is not completely understood. We studied the interactions of opioid and adrenergic receptor agonists in the NG108-15 cells, which are a model of opiate dependence.
José M. Musacchio +2 more
openaire +3 more sources