Results 171 to 180 of about 41,601 (289)

Cross-Talk Between Signaling and Transcriptional Networks Regulating Thermogenesis-Insights into Canonical and Non-Canonical Regulatory Pathways. [PDF]

Int J Mol Sci
Simka-Lampa K.
europepmc   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

The Comparative Effectiveness of PDE5 Inhibitors and β3 Agonists Versus α-Blockers in Medical Expulsive Therapy for Distal Ureteric Stones: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Cureus
Ramanah M, Banerjee I, Nunkoo S, Robinson J, Krissheeven M, Banerjee I.   +5 more
europepmc   +1 more source

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview

American Journal of Hematology, Volume 101, Issue S1, Page 56-74, April 2026.
ABSTRACT The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs.
Adetola A. Kassim, Alexis A. Thompson, Punam Malik   +2 more
wiley   +1 more source

Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche. [PDF]

Bone Res
Chen Z, Luo Z, Greenblatt MB, Wu Z, Xu R.   +4 more
europepmc   +1 more source

Drug‐Induced Raynaud's Phenomenon and Underlying Mechanism: A Disproportionality Analysis From the World Health Organization Pharmacovigilance Database

Arthritis &Rheumatology, Volume 78, Issue 4, Page 985-992, April 2026.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's phenomenon (RP) and to explore their potential pathophysiologic mechanisms through a mixed disproportionality/clustering analysis from the World Health Organization (WHO) pharmacovigilance database.
Alex Hlavaty, Loubna Dari, Jean‐Luc Cracowski, Matthieu Roustit, Charles Khouri   +4 more
wiley   +1 more source

Oncosexology: A Narrative Review on Sexual Health and Quality of Life in Cancer Patients

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer remains a major global public health problem. A key aspect of cancer care among survivors is sexual health. Cancer patients experience a range of sexual dysfunctions, including erectile dysfunction, vaginal dryness, dyspareunia, and reduced libido.
Pasquale Marino, Roberta Colangelo, Paola Amendola, Ilaria Bochicchio, Alessandro Rocco Lettini, Stefania Lapadula, Alda Giuliano, Martina Catalano, Francesca Sanseverino   +8 more
wiley   +1 more source

Thermogenesis in Adipose Tissue: Adrenergic and Non-Adrenergic Pathways. [PDF]

Cells
Hossain MA, Poojari A, Rabiee A.
europepmc   +1 more source

Antinociceptive Effect of Cinnamaldehyde in Male Mice: Investigation of the Mechanisms of Action Through In Silico and In Vivo Approaches

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Cinnamaldehyde (CA), a major component of Cinnamomum spp. essential oils, has recognized bioactivity, including possible analgesic effects. However, its acute antinociceptive mechanisms remain unclear. This study assessed the influence of CA (15, 30, and 60 mg/kg, p.o.) on locomotor and exploratory behaviors via rotarod and open field tests in
Renaly I. de A. Rêgo, Hugo F. O. Pires, Arthur L. Dias, Maria Caroline R. B. Remigio, Humberto H. N. de Andrade, Pablo R. da Silva, Natália F. de Sousa, Luciana Scotti, Marcus T. Scotti, Mirian G. S. S. Salvadori, Ricardo D. de Castro   +10 more
wiley   +1 more source

The Brain‐Gut Axis in Parkinson's Disease Pathology

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Exposure to environmental toxins induces gut dysbiosis, increases intestinal epithelial barrier permeability, immune activation, and oxidative stress, promoting α‐syn misfolding and propagation. Brainstem DMV neurons exhibit α‐syn pathology, dysregulating neuronal excitability and vagal control of GI functions.
Kudret Selin Ozkaya, Kirsteen N. Browning   +1 more
wiley   +1 more source