Results 171 to 180 of about 20,695 (270)

Spinal motoneuron excitability is homeostatically regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice. [PDF]

Prog Neurobiol
Antonucci S, Caron G, Dikwella N, Krishnamurthy SS, Harster A, Wasicki B, Zarrin H, Tahanis A, Heuvel FO, Danner SM, Ludolph AC, Grycz K, Bączyk M, Zytnicki D, Roselli F.   +14 more
europepmc   +1 more source

Nociceptin/orphanin FQ – NOP receptor system: novel genetic and pharmacological tools

, 2012
The neuropeptide nociceptin/orphanin FQ (N/OFQ) selectively binds and activates the N/OFQ peptide (NOP) receptor. In cells expressing the NOP receptor N/OFQ inhibits cAMP accumulation and Ca2+ conductance and stimulates K+ currents.
Molinari, Stefano
core  

The Effect of Ketamine, Xylazine, and Ketamine/Xylazine Administration on SCN5A (Nav1.5) Gene Expression in Pigeons

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Voltage‐gated sodium channels, particularly Nav1.5 encoded by the SCN5A gene, play essential roles in neuronal conduction and cardiac function. Given the widespread use of anaesthetic agents such as ketamine and xylazine in animal studies, this study aimed to evaluate their effects on SCN5A gene expression in pigeon heart tissue.
Faezeh Sadat Moazzeni, Behnam Pedram, Seyed Morteza Razaghi Manesh   +2 more
wiley   +1 more source

Brimonidine Beyond a Single Specialty: Pharmacological Profile, Dermatologic Applications, and Advances in Drug Delivery Systems. [PDF]

Int J Mol Sci
Jóźwiak W, Pietrusiewicz M, Piechota-Urbańska M, Markowicz-Piasecka M.   +3 more
europepmc   +1 more source

The Orexin System Modulates Stress‐Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence

Addiction Biology, Volume 31, Issue 7, July 2026.
Chronic foot stress increases the vulnerability of adolescent mice to alcohol addiction‐related behaviours. Acute foot stress promotes the recovery of alcohol‐seeking behaviour in adolescent mice and increases orexin concentrations in the hippocampus, nucleus accumbens and prefrontal cortex.
Wenhao He, Aqian Hu, Tianshu Zhao, Li Deng, Huilin Wu, Xiaojun Xiang   +5 more
wiley   +1 more source

Prostaglandin analog therapy challenges and innovation in glaucoma therapeutics. [PDF]

Indian J Ophthalmol
Nath M, Alam K, Halder N, Dada T, Thirumurthy V.   +4 more
europepmc   +1 more source

Efficacy and safety of different vasopressor infusions on feto‐maternal outcomes in normotensive patients undergoing caesarean delivery: a systematic review and network meta‐analysis of randomised controlled trials

Anaesthesia, Volume 81, Issue 7, Page 995-1007, July 2026.
Summary Introduction Phenylephrine infusion is widely endorsed by guidelines as the preferred prophylactic drug for spinal hypotension in patients undergoing caesarean delivery; however, clinical practice continues to show marked variability in the selection of vasopressor drugs.
Narinder Pal Singh, Jeetinder Kaur Makkar, Bisman Jeet Kaur Khurana, Anuradha Borle, Preet Mohinder Singh   +4 more
wiley   +1 more source

Intranasal dexmedetomidine for perioperative analgesia in a patient on naltrexone maintenance therapy. [PDF]

Indian J Anaesth
Rangari A, Singh S, Mittal S, Garg H.
europepmc   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Xylazine Exposure and Association With Early Physiological and Withdrawal Symptoms in People With Opioid Use Disorder. [PDF]

J Addict Med
Strickland JC, Bergeria CL, Huhn AS, McKendrick G, Srungaram D, Pattillo E, Dunn KE.   +6 more
europepmc   +1 more source