Results 191 to 200 of about 41,601 (289)

Evidence that xylazine disrupts skin homeostasis by acting on epithelial cells through the kappa opioid receptor. [PDF]

Dis Model Mech
Robertson TF, Horn A, Smith FM, Huttenlocher A.   +3 more
europepmc   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, Volume 40, Issue 4, Page 1970-2002, April 2026.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Vitamin A Derivatives and Adipose Tissue Differentiation: Molecular Pathways Driving Browning and Anti-Obesity Effects. [PDF]

Curr Obes Rep
Bilikozen Aygun B, Basturk B, Ayaz A.
europepmc   +1 more source

Angiotensin‐(1–7) Alleviates Isoproterenol‐Induced Cardiac Hypertrophy by Suppressing Autophagy and Apoptosis Through the Synergistic Action of Mas Receptor and Angiotensin II Type 2 Receptor

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim The aim of this study is to determine whether Angiotensin‐(1–7) [Ang‐(1–7)] alleviates isoproterenol (ISO)–induced cardiac hypertrophy by suppressing excessive autophagy and apoptosis through coordinated Mas receptor (MasR) and angiotensin II type‐2 receptor (AT2R) signaling, and to elucidate the underlying mechanisms.
Xiaomei Wang, Fei Guo, Xiaoqian Wang, Yu Guo, Siyao Fan, Lan Hong, Honghua Jin   +6 more
wiley   +1 more source

Beta 2 adrenergic receptor agonists as a treatment for metabolic dysfunction-associated steatohepatitis (MASH). [PDF]

NPJ Metab Health Dis
Winkler BS, Stayer KM, Rao AK, Arif E, Mendenhall TT, Thomas KL, Driggers KR, Zuo X, Fitzgibbon W, Deng P, Su Y, Dang Y, Gerges M, Kagan D, Pasham V, Wolf B, Rockey DC, Hartman JH, Lipschutz JH.   +18 more
europepmc   +1 more source

3,4‐Methylenedioxymethamphetamine (MDMA) does not induce robust psychomotor activation and 50‐kHz ultrasonic vocalisations in tryptophan hydroxylase 2 (Tph2)‐deficient rats lacking serotonin in the central nervous system

British Journal of Pharmacology, Volume 183, Issue 7, Page 1539-1556, April 2026.
Background and Purpose 3,4‐Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, is a psychostimulant with entactogenic properties and known to induce arousal and euphoria. As an amphetamine derivate, MDMA acts on the monoamine systems in the brain and stimulates release of dopamine (DA), noradrenaline (NA) and serotonin (5‐HT), yet their ...
Tianhua Wang, Rainer K. W. Schwarting, Markus Wöhr   +2 more
wiley   +1 more source

Biased Orthosteric Agonism and Allosteric Modulation: Emerging Strategies for Developing New Class of β-Agonists for Obstructive Airway Diseases. [PDF]

Am J Respir Cell Mol Biol
Shah SD, Deshpande DA.
europepmc   +1 more source

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, Volume 38, Issue 4, Page 220-228, April 2026.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source

Multicomplex Pharmacophore Modeling of Estrogen Receptors Suggests the Probable Repurposing of Procaterol as an Antiproliferative Agent Against Breast Cancer Cells. [PDF]

Int J Mol Sci
Vazquez-Mendoza LH, Mendoza-Figueroa HL, Jacobo-Herrera NJ, Bakalara N, González-Juárez DE, Correa-Basurto J, García-Vázquez JB.   +6 more
europepmc   +1 more source

Efficacy of AOPT Combined With Collagen Dressings on Facial Flushing and Skin Barrier Function in Patients With Rosacea

International Wound Journal, Volume 23, Issue 4, April 2026.
ABSTRACT This study aimed to evaluate the efficacy of advanced optimal pulse technology (AOPT) combined with collagen dressings on facial flushing and skin barrier function in patients with rosacea. A total of 150 patients with rosacea were prospectively enrolled and randomised into the control group (n = 75, received AOPT treatment alone) and ...
Jinzhu Mao, Mengyao Yang
wiley   +1 more source