Results 201 to 210 of about 41,601 (289)

Fixed-proportion mixtures with the α2-adrenergic agonist clonidine or lofexidine do not alter fentanyl self-administration in non-opioid-dependent male and female rats. [PDF]

J Pharmacol Exp Ther
Ortiz A, St Onge CM, Banks ML.
europepmc   +1 more source

The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Ana B. Caniceiro, Sofia P. Agostinho, Luiz F. Piochi, Nícia Rosário‐Ferreira, Irina S. Moreira   +4 more
wiley   +1 more source

Aβ and tau clearance through aerobic exercise: unveiling the β2-adrenergic receptor's role in regulating autophagy-lysosomal pathways. [PDF]

Autophagy Rep
Yang L, Yu H, Chai GS.
europepmc   +1 more source

International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease

Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.
As an orphan disease, where treatment is not curative and diagnosis is often slow, VSCM represents a serious health and social problem requiring research efforts in several directions. ABSTRACT Background Visceral myopathy (VSCM) is an ultra‐rare life‐threatening condition characterized by severe impairment of gastrointestinal (GI), genitourinary, and ...
Pascal De Santa Barbara, Isabella Ceccherini, Robert O. Heuckeroth, Carlo Di Lorenzo, Maria M. Alves, Arthur Beyder, Osvaldo Borrelli, Ludovica Cacopardo, Rachel Ceron, Jihong Chen, Federica Chiappori, Antonio Contessa, Roberto De Giorgio, Antonella Diamanti, Maria Grazia Faticato, Sandrine Faure, Sohaib K. Hashmi, Jan D. Huizinga, Raj P. Kapur, Cecile Lambe, Laurence Lancon, Ryan McManigal, Hayat Mousa, Alessandro Palmitelli, Victor Perreaux, Alessio Pini Prato, Michela Pitto, Elisa Proietti, John Rendu, Anna Rybak, Kenton M. Sanders, Sabah Sardar, Vincenzo Stanghellini, Renato Tambucci, Nikhil Thapar, Pieter Vanden Berghe, Massimo Vassalli, Qianqian Wang, Michael Wangler, Sharon Wolfson, Almira Zada, Jiliang Zhou, Federica Viti   +42 more
wiley   +1 more source

Diet-Induced Browning of White Adipose Tissue: Molecular Targets, Mechanisms, and Therapeutic Potential. [PDF]

Curr Issues Mol Biol
Yang ZD, Chen JW, Mei YX, Xia XW, Gong YJ, Ding WJ.   +5 more
europepmc   +1 more source

Cervical epidural catheter for administration of detomidine and morphine in a model of carpal synovitis in the horse

Veterinary Surgery, Volume 55, Issue 3, Page 646-656, April 2026.
Abstract Objective To determine the analgesic effects of detomidine and morphine administered by cervical epidural catheter (CEC) on a model of thoracic limb pain. Study design Prospective, randomized, blinded crossover study. Animals Five adult horses.
Veronica L. Edwards, Rachel Reed, Michael Perlini, Valerie J. Moorman   +3 more
wiley   +1 more source

sAlpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failure. [PDF]

Front Pharmacol
Swiderski J, Gadanec LK, Hearth S, Rowlands BD, Murphy AJ, Apostolopoulos V, Zulli A.   +6 more
europepmc   +1 more source

Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy

Experimental Physiology, Volume 111, Issue 4, Page 1875-1890, 1 April 2026.
Abstract Attenuation of sympathetic vasoconstriction during exercise (functional sympatholysis) contributes to skeletal muscle oxygen delivery–utilization matching. However, the extent to which muscle contractions impact noradrenergic regulation of interstitial oxygen pressures (PO2is${P_{{{\mathrm{O}}_2}}}_{{\mathrm{is}}}$; the driving force for blood–
Edward T. N. Calvo, Jacob M. Pontorno, Benjamin Zeidler, Taciane M. M. Pejon, Michael D. Belbis, Scott K. Ferguson, Craig J. Goergen, Timothy P. Gavin, Bruno T. Roseguini, Igor A. Fernandes, Daniel M. Hirai   +10 more
wiley   +1 more source

Evaluation of the Effect of Alpha2-Adrenergic Receptor Stimulation on Prolactin Secretion Using the Clonidine Test in the Diagnosis of Children with Short Stature. [PDF]

Int J Mol Sci
Pakuła A, Fedorczak A, Kolasa-Kicińska M, Łupińska A, Hilczer M, Zygmunt A, Stawerska R.   +6 more
europepmc   +1 more source

The skeletal muscle–adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management

Experimental Physiology, Volume 111, Issue 4, Page 1700-1707, 1 April 2026.
Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su, Na Liu, Yang Liu, Yiqun Sun, Yike Jiao   +4 more
wiley   +1 more source