Results 201 to 210 of about 20,601 (250)
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Pharmacological screening of a new alpha-2 adrenergic receptor agonist, mafedine, in zebrafish
Neuroscience Letters, 2019Pharmacological agents acting at alpha-2 adrenergic receptors are widely used in physiology and neuroscience research. Mounting evidence of their potential utility in clinical and experimental psychopharmacology, necessitates new models and novel model organisms for their screening. Here, we characterize behavioral effects of mafedine (6-oxo-1-phenyl-2-
Yuriy I. Sysoev +5 more
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p-[125I]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor.
Molecular Pharmacology, 1990The binding properties of p-[125I]iodoclonidine [( 125I]PIC) to human platelet membranes and the functional characteristics of PIC are reported. [125I]PIC bound rapidly and reversibly to platelet membranes, with a first-order association rate constant (kon) at room temperature of 8.0 +/- 2.7 x 10(6) M-1 sec-1 and a dissociation rate constant (koff) of ...
M A, Gerhardt, S M, Wade, R R, Neubig
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Effects of an Alpha-2 Adrenergic Receptor Agonist in Spinal Rats
1988It is now several decades that diverse surgical and pharmacological treatments have been employed to prevent and/or ameliorate the sensory motor deficits which ensue an injury to the spinal cord. The restoration of impaired histological and physiologic parameters by compounds which are membrane stabilizers, antiinflammatory, and antioxidant, and which ...
N. E. Naftchi, R. Lehrer, J. A. Sleis
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Peripheral nociceptive effects of α2-adrenergic receptor agonists in the rat
Neuroscience, 1995We have previously shown that norepinephrine can produce hyperalgesia via an alpha 2-adrenergic receptor mechanism. The alpha 2-adrenergic receptor agonist clonidine has, however, also been shown to produce peripheral analgesia. In view of the multiple alpha 2-subtypes currently known (i.e.
S G, Khasar +3 more
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Archives des maladies du coeur et des vaisseaux, 1989
Imidazolines have been proposed as highly selective drugs for alpha 2-adrenergic receptors. However, we have recently showed that the imidazoline ligand 3H-RX 781094 (idazoxan) binds to both alpha 2-receptors and imidazoline guanidinium receptive substance (IGRS) in rabbit renal proximal tubule.
V, Lachaud +4 more
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Imidazolines have been proposed as highly selective drugs for alpha 2-adrenergic receptors. However, we have recently showed that the imidazoline ligand 3H-RX 781094 (idazoxan) binds to both alpha 2-receptors and imidazoline guanidinium receptive substance (IGRS) in rabbit renal proximal tubule.
V, Lachaud +4 more
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Management of Traumatic Brain Injury Sequelae With Alpha-2 Adrenergic Receptor Agonists
Journal of Head Trauma RehabilitationObjective: To describe clinical uses of the class of alpha-2 receptor agonist medications in the treatment of traumatic brain injury sequelae. Clinicians treating patients with traumatic brain injuries (TBI) will often see patients who have been prescribed alpha-2 agonists or may consider initiating use.
Jamie L. Ott, Thomas K. Watanabe
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The Journal of Pharmacology and Experimental Therapeutics, 1982
The alpha-1 and alpha-2 adrenergic effects of cirazoline were evaluated in guinea-pig aorta and field-stimulated guinea-pig ileum, respectively. Cirazoline was found to be a full agonist at alpha-1 receptors having an ED50, dissociation constant (KA) and relative efficacy similar to that of (-)-norepinephrine.
R R, Ruffolo, J E, Waddell
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The alpha-1 and alpha-2 adrenergic effects of cirazoline were evaluated in guinea-pig aorta and field-stimulated guinea-pig ileum, respectively. Cirazoline was found to be a full agonist at alpha-1 receptors having an ED50, dissociation constant (KA) and relative efficacy similar to that of (-)-norepinephrine.
R R, Ruffolo, J E, Waddell
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Biochemistry, 1988
The alpha 2 adrenergic receptor (AR) inhibits adenylate cyclase via an interaction with Ni, a guanine nucleotide binding protein. The early steps involved in the activation of the alpha 2 AR by agonists and the subsequent interaction with Ni are poorly understood.
R R, Neubig, R D, Gantzos, W J, Thomsen
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The alpha 2 adrenergic receptor (AR) inhibits adenylate cyclase via an interaction with Ni, a guanine nucleotide binding protein. The early steps involved in the activation of the alpha 2 AR by agonists and the subsequent interaction with Ni are poorly understood.
R R, Neubig, R D, Gantzos, W J, Thomsen
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Structure—Activity Relationships for alpha-2 Adrenergic Receptor Agonists and Antagonists
1988This chapter extends the discussion provided in Chapter 1 by providing an overview of the development of criteria for subclassification of alpha-adrenergic receptors into alpha-1 vs alpha-2 adrenergic receptor sybtypes and of more recent data suggesting the existence of subtypes of alpha-2 adrenergic receptors.
Robert R. Ruffolo +3 more
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Biochemical and Biophysical Research Communications, 1981
Abstract Alpha2 adrenergic receptors were solubilized from human platelet particulate preparations with digitonin. The solubilized alpha2 receptors retained the essential binding specificity characteristics of the membrane-bound receptors. The alpha2 receptors could be labelled in platelet membranes with either agonist ([3H]epinephrine) or antagonist
T, Michel +3 more
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Abstract Alpha2 adrenergic receptors were solubilized from human platelet particulate preparations with digitonin. The solubilized alpha2 receptors retained the essential binding specificity characteristics of the membrane-bound receptors. The alpha2 receptors could be labelled in platelet membranes with either agonist ([3H]epinephrine) or antagonist
T, Michel +3 more
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