Results 211 to 220 of about 20,601 (250)
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Molecular Pharmacology, 1990
Unlabeled p-iodoclonidine was efficacious in attenuating forskolin-stimulated cAMP accumulation in SK-N-SH neuroblastoma cells. Maximal attenuation was 76 +/- 3%, with an EC50 of 347 +/- 60 nM. Comparable values of epinephrine were 72 +/- 3% and 122 +/- 22 nM. Responses to both agonists were abolished by 10 microM phentolamine.
B M, Baron, B W, Siegel
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Unlabeled p-iodoclonidine was efficacious in attenuating forskolin-stimulated cAMP accumulation in SK-N-SH neuroblastoma cells. Maximal attenuation was 76 +/- 3%, with an EC50 of 347 +/- 60 nM. Comparable values of epinephrine were 72 +/- 3% and 122 +/- 22 nM. Responses to both agonists were abolished by 10 microM phentolamine.
B M, Baron, B W, Siegel
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[Adrenergic receptor and alpha 2 agonist--4: Applied and clinical pharmacology of alpha 2 agonist].
Masui. The Japanese journal of anesthesiology, 1997Alpha 2 adrenergic agonists currently are used in the anesthetic management of the surgical patient for their sedative/hypnotic, anesthetic-sparing, analgesic, and sympatholytic properties. Experimental and clinical studies have progressed to the point where anesthesiologists are now focusing on the use of these agents for their analgesic and ...
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Molecular Pharmacology, 1987
alpha 2-Adrenergic receptors in calf retina membranes can be specifically labeled with the tritiated antagonist 3H-RX 781094. Saturation binding occurs to a single class of noncooperative sites. The number of sites amounts to 1070 +/- 243 and 935 +/- 178 fmol/mg of protein, and the equilibrium dissociation constants equal 1.8 +/- 0.4 and 3.8 +/- 0.3 nM
A, Convents +3 more
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alpha 2-Adrenergic receptors in calf retina membranes can be specifically labeled with the tritiated antagonist 3H-RX 781094. Saturation binding occurs to a single class of noncooperative sites. The number of sites amounts to 1070 +/- 243 and 935 +/- 178 fmol/mg of protein, and the equilibrium dissociation constants equal 1.8 +/- 0.4 and 3.8 +/- 0.3 nM
A, Convents +3 more
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[Radiation-protective effect of agonists of alpha-2 adrenergic receptors. Methyldopa].
Radiatsionnaia biologiia, radioecologiia, 1997MethylDOPA has the considerable (60-80%) and lasting RPE at both intraperitoneal (0.5-3.8 mmol/kg) and per os (3.8-7.1 mmol/kg) introduction in radiation dose 8 Gr (LD97/30). Optimal time for introduction is 0.5-3.0 hours intraperitoneally and 3-6 hours per os. Evidently, methylDOPA RPE is realized via alpha 2-adrenoceptors.
V I, Kulinskiĭ +3 more
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[Protective effect of adrenergic alpha 2-receptor agonists in hypoxic hypoxia].
Biulleten' eksperimental'noi biologii i meditsiny, 1986The antihypoxic effect of alpha 2-adrenoceptor agonists was studied by two different approaches: reproduction of the effect by a number of alpha 2-agonists and its blockade with selective antagonists. The data obtained suggest that alpha 2-adrenoceptor agonists increase the survival and the lifespan of mice in all the models of acute hypoxic hypoxia ...
V I, Kulinskiĭ +2 more
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GTP regulates binding of agonists to alpha 2-adrenergic receptors in human platelets.
Archives internationales de pharmacodynamie et de therapie, 1982The potent alpha 2-adrenergic receptor antagonist 3H-yohimbine was used to characterize alpha-adrenergic receptors in human platelet membranes. Binding of 3H-yohimbine was at 25 degrees rapid (t 1/2 = 3 min) readily reversible (t 1/2 = 5.5 min), saturable with 221 +/- 38.9 fmoles bound/mg protein (N = 10) and of high affinity (KD = 1.97 nM). Inhibition
O E, Brodde +3 more
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Journal of cyclic nucleotide and protein phosphorylation research, 1985
Alpha 2-adrenergic receptors linked to inhibition of adenylate cyclase activity in human platelet membranes can be isolated using DEAE chromatography following solubilization into digitonin-containing buffers. This procedure permits resolution of agonist-occupied receptors from antagonist-occupied receptors.
L E, Limbird +2 more
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Alpha 2-adrenergic receptors linked to inhibition of adenylate cyclase activity in human platelet membranes can be isolated using DEAE chromatography following solubilization into digitonin-containing buffers. This procedure permits resolution of agonist-occupied receptors from antagonist-occupied receptors.
L E, Limbird +2 more
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Increase in human platelet alpha 2-adrenergic receptor affinity for agonist in unstable angina.
The Journal of laboratory and clinical medicine, 1986Spontaneous increase in platelet activity and change in coronary vasomotor tone have been implicated in the pathogenesis of acute myocardial ischemia. To define the mechanism of platelet "hypersensitivity" in acute myocardial ischemia, we examined the status of platelet alpha 2-adrenergic receptors in patients hospitalized with severe unstable angina ...
J, Mehta, P, Mehta, N, Ostrowski
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Analgesic and Side Effect Profiles of Novel Alpha-2 Adrenergic Receptor Agonists
The Journal of Pharmacology and Experimental Therapeutics, 2023Cristina D. Peterson +6 more
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[Adrenergic receptors and alpha 2 agonists--1) Molecular biological study of adrenoceptors].
Masui. The Japanese journal of anesthesiology, 1997Molecular biological studies have established classification of adrenergic receptors 40 years after Prof Ahlquist first classified them into alpha and beta. They are now classified into 9 subtypes consisting of 400 to 480 amino acids. They belong to a super-family of G-protein coupled receptors.
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