Results 231 to 240 of about 20,695 (270)

Management of Traumatic Brain Injury Sequelae With Alpha-2 Adrenergic Receptor Agonists

Journal of Head Trauma Rehabilitation
Objective: To describe clinical uses of the class of alpha-2 receptor agonist medications in the treatment of traumatic brain injury sequelae. Clinicians treating patients with traumatic brain injuries (TBI) will often see patients who have been prescribed alpha-2 agonists or may consider initiating use.
Jamie L. Ott, Thomas K. Watanabe
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Different sedimentation properties of agonist- and antagonist-labelled platelet alpha2 adrenergic receptors

Biochemical and Biophysical Research Communications, 1981
Abstract Alpha2 adrenergic receptors were solubilized from human platelet particulate preparations with digitonin. The solubilized alpha2 receptors retained the essential binding specificity characteristics of the membrane-bound receptors. The alpha2 receptors could be labelled in platelet membranes with either agonist ([3H]epinephrine) or antagonist
T, Michel, B B, Hoffman, R J, Lefkowitz, M G, Caron   +3 more
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Structure—Activity Relationships for alpha-2 Adrenergic Receptor Agonists and Antagonists

1988
This chapter extends the discussion provided in Chapter 1 by providing an overview of the development of criteria for subclassification of alpha-adrenergic receptors into alpha-1 vs alpha-2 adrenergic receptor sybtypes and of more recent data suggesting the existence of subtypes of alpha-2 adrenergic receptors.
Robert R. Ruffolo, Robert M. DeMarinis, Margaret Wise, J. Paul Hieble   +3 more
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p-[125I]iodoclonidine, a novel radiolabeled agonist for studying central alpha 2-adrenergic receptors.

Molecular Pharmacology, 1990
Unlabeled p-iodoclonidine was efficacious in attenuating forskolin-stimulated cAMP accumulation in SK-N-SH neuroblastoma cells. Maximal attenuation was 76 +/- 3%, with an EC50 of 347 +/- 60 nM. Comparable values of epinephrine were 72 +/- 3% and 122 +/- 22 nM. Responses to both agonists were abolished by 10 microM phentolamine.
B M, Baron, B W, Siegel
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Tight agonist binding may prevent the correct interpretation of agonist competition binding curves for alpha 2-adrenergic receptors.

Molecular Pharmacology, 1987
alpha 2-Adrenergic receptors in calf retina membranes can be specifically labeled with the tritiated antagonist 3H-RX 781094. Saturation binding occurs to a single class of noncooperative sites. The number of sites amounts to 1070 +/- 243 and 935 +/- 178 fmol/mg of protein, and the equilibrium dissociation constants equal 1.8 +/- 0.4 and 3.8 +/- 0.3 nM
A, Convents, J P, De Backer, D, Convents, G, Vauquelin   +3 more
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[Radiation-protective effect of agonists of alpha-2 adrenergic receptors. Methyldopa].

Radiatsionnaia biologiia, radioecologiia, 1997
MethylDOPA has the considerable (60-80%) and lasting RPE at both intraperitoneal (0.5-3.8 mmol/kg) and per os (3.8-7.1 mmol/kg) introduction in radiation dose 8 Gr (LD97/30). Optimal time for introduction is 0.5-3.0 hours intraperitoneally and 3-6 hours per os. Evidently, methylDOPA RPE is realized via alpha 2-adrenoceptors.
V I, Kulinskiĭ, V Iu, Kovtun, V G, Iashunskiĭ, A L, Klimova   +3 more
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Moxonidine, a Mixed a₂‐Adrenergic and Imidazoline Receptor Agonist, Identifies a Novel Adrenergic Target for Spinal Analgesia

Annals of the New York Academy of Sciences, 2003
Abstract: Moxonidine is a mixed a2‐adrenergic and imidazoline receptor agonist with an improved side effect profile compared to clonidine. Intrathecal (i.t.) moxonidine has been found to possess analgesic activity that, in contrast to the majority of a2‐adrenoceptor (a2AR) agonists, does not require activation of the a2AAR subtype, which mediates many
Laura S, Stone, Carolyn A, Fairbanks, George L, Wilcox   +2 more
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Plasma thyrotrophin (TSH) response to intrahypothalamic injection of an α2-adrenergic receptor agonist (clonidine)

Acta Endocrinologica, 1986
Abstract. To delineate the site at which the central noradrenergic (NE) system may exert its stimulatory influence on the thyrotrophin (TSH) secretion, plasma TSH concentrations were measured before and after clonidine (an α2-agonist) administration to the hypothalamus of unanaesthetized, unrestrained rats.
K, Ishikawa, T, Kakegawa, M, Suzuki
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[Adrenergic receptor and alpha 2 agonist--4: Applied and clinical pharmacology of alpha 2 agonist].

Masui. The Japanese journal of anesthesiology, 1997
Alpha 2 adrenergic agonists currently are used in the anesthetic management of the surgical patient for their sedative/hypnotic, anesthetic-sparing, analgesic, and sympatholytic properties. Experimental and clinical studies have progressed to the point where anesthesiologists are now focusing on the use of these agents for their analgesic and ...
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[Protective effect of adrenergic alpha 2-receptor agonists in hypoxic hypoxia].

Biulleten' eksperimental'noi biologii i meditsiny, 1986
The antihypoxic effect of alpha 2-adrenoceptor agonists was studied by two different approaches: reproduction of the effect by a number of alpha 2-agonists and its blockade with selective antagonists. The data obtained suggest that alpha 2-adrenoceptor agonists increase the survival and the lifespan of mice in all the models of acute hypoxic hypoxia ...
V I, Kulinskiĭ, I A, Ol'khovskiĭ, A N, Kovalevskiĭ   +2 more
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