Results 231 to 240 of about 41,601 (289)

Alpha-2 Adrenergic Receptor Agonists are Neuroprotective in Experimental Models of Glaucoma

European Journal of Ophthalmology, 2001
PurposeThe glaucomas are characterized by chronic progressive ganglion cell loss over many years. A drug with neuroprotective activity should increase the resistance of retinal ganglion cells (RGC) to chronic stress or injury and therefore enhance survival.
L A, Wheeler, E, Woldemussie
openaire   +2 more sources

Different Affinities of α2-Agonists for Imidazoline and α2-Adrenergic Receptors

American Journal of Hypertension, 1989
It has recently been shown that imidazoline alpha 2-adrenergic agonists, such as clonidine and UK 14,304, selectively bind to both alpha 2- and imidazoline receptors in basolateral membranes from rabbit renal proximal tubule. In order to define the relative affinity of three antihypertensive alpha 2-agonists for the two classes of receptors, we ...
I, Coupry, V, Lachaud, R A, Podevin, E, Koenig, A, Parini   +4 more
openaire   +2 more sources

Alpha-2 Adrenergic Receptor Agonists

2014
Alpha-2 adrenergic receptor agonists include clonidine, guanfacine, guanabenz, methyldopa, rilmenidine, and moxonidine. These are centrally active antihypertensive drugs.
Esen Özkaya, Kurtuluş Didem Yazganoğlu   +1 more
openaire   +1 more source

Pharmacological screening of a new alpha-2 adrenergic receptor agonist, mafedine, in zebrafish

Neuroscience Letters, 2019
Pharmacological agents acting at alpha-2 adrenergic receptors are widely used in physiology and neuroscience research. Mounting evidence of their potential utility in clinical and experimental psychopharmacology, necessitates new models and novel model organisms for their screening. Here, we characterize behavioral effects of mafedine (6-oxo-1-phenyl-2-
Yuriy I. Sysoev, Darya A. Meshalkina, Daniil V. Petrov, Sergey V. Okovityi, Pavel E. Musienko, Allan V. Kalueff   +5 more
openaire   +2 more sources

Peripheral nociceptive effects of α2-adrenergic receptor agonists in the rat

Neuroscience, 1995
We have previously shown that norepinephrine can produce hyperalgesia via an alpha 2-adrenergic receptor mechanism. The alpha 2-adrenergic receptor agonist clonidine has, however, also been shown to produce peripheral analgesia. In view of the multiple alpha 2-subtypes currently known (i.e.
S G, Khasar, P G, Green, B, Chou, J D, Levine   +3 more
openaire   +2 more sources

[Selectivity of alpha 2-adrenergic agonists for the imidazoline-guanidine and alpha 2-adrenergic receptors].

Archives des maladies du coeur et des vaisseaux, 1989
Imidazolines have been proposed as highly selective drugs for alpha 2-adrenergic receptors. However, we have recently showed that the imidazoline ligand 3H-RX 781094 (idazoxan) binds to both alpha 2-receptors and imidazoline guanidinium receptive substance (IGRS) in rabbit renal proximal tubule.
V, Lachaud, I, Coupry, R A, Podevin, E, Koenig, A, Parini   +4 more
openaire   +1 more source