Results 251 to 260 of about 41,601 (289)

Mechanism of agonist and antagonist binding to .alpha.2 adrenergic receptors: evidence for a precoupled receptor-guanine nucleotide protein complex

Biochemistry, 1988
The alpha 2 adrenergic receptor (AR) inhibits adenylate cyclase via an interaction with Ni, a guanine nucleotide binding protein. The early steps involved in the activation of the alpha 2 AR by agonists and the subsequent interaction with Ni are poorly understood.
R R, Neubig, R D, Gantzos, W J, Thomsen
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Management of Traumatic Brain Injury Sequelae With Alpha-2 Adrenergic Receptor Agonists

Journal of Head Trauma Rehabilitation
Objective: To describe clinical uses of the class of alpha-2 receptor agonist medications in the treatment of traumatic brain injury sequelae. Clinicians treating patients with traumatic brain injuries (TBI) will often see patients who have been prescribed alpha-2 agonists or may consider initiating use.
Jamie L. Ott, Thomas K. Watanabe
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Plasma thyrotrophin (TSH) response to intrahypothalamic injection of an α2-adrenergic receptor agonist (clonidine)

Acta Endocrinologica, 1986
Abstract. To delineate the site at which the central noradrenergic (NE) system may exert its stimulatory influence on the thyrotrophin (TSH) secretion, plasma TSH concentrations were measured before and after clonidine (an α2-agonist) administration to the hypothalamus of unanaesthetized, unrestrained rats.
K, Ishikawa, T, Kakegawa, M, Suzuki
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Cross‐dependence to opioid and α ₂ ‐adrenergic receptor agonists in NG108‐15 cells

The FASEB Journal, 1988
Clonidine, a partial α 2 agonist, has been used empirically to alleviate opiate withdrawal symptoms, but the mechanism of its effects is not completely understood. We studied the interactions of opioid and adrenergic receptor agonists in the NG108‐15 cells, which are a model of opiate ...
S, Lee, C R, Rosenberg, J M, Musacchio
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[Adrenergic receptor and alpha 2 agonist--4: Applied and clinical pharmacology of alpha 2 agonist].

Masui. The Japanese journal of anesthesiology, 1997
Alpha 2 adrenergic agonists currently are used in the anesthetic management of the surgical patient for their sedative/hypnotic, anesthetic-sparing, analgesic, and sympatholytic properties. Experimental and clinical studies have progressed to the point where anesthesiologists are now focusing on the use of these agents for their analgesic and ...
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Moxonidine, a Mixed a₂‐Adrenergic and Imidazoline Receptor Agonist, Identifies a Novel Adrenergic Target for Spinal Analgesia

Annals of the New York Academy of Sciences, 2003
Abstract: Moxonidine is a mixed a2‐adrenergic and imidazoline receptor agonist with an improved side effect profile compared to clonidine. Intrathecal (i.t.) moxonidine has been found to possess analgesic activity that, in contrast to the majority of a2‐adrenoceptor (a2AR) agonists, does not require activation of the a2AAR subtype, which mediates many
Laura S, Stone, Carolyn A, Fairbanks, George L, Wilcox   +2 more
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Functional α2-Adrenergic Receptor-Gs Coupling Undergoes Agonist-Promoted Desensitization in a Subtype-Selective Manner

Biochemical and Biophysical Research Communications, 1993
Recently it has become clear that alpha 2-adrenergic receptors (alpha 2AR) functionally couple to Gs as well as Gi, thus inducing a complex modulation of adenylyl cyclase activity. It is unknown whether alpha 2AR-Gs coupling undergoes agonist-promoted desensitization.
M G, Eason, S B, Liggett
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The resolution of agonist alpha 2-adrenergic receptor complexes from unoccupied receptors or antagonist-alpha 2 receptor complexes using DEAE chromatography.

Journal of cyclic nucleotide and protein phosphorylation research, 1985
Alpha 2-adrenergic receptors linked to inhibition of adenylate cyclase activity in human platelet membranes can be isolated using DEAE chromatography following solubilization into digitonin-containing buffers. This procedure permits resolution of agonist-occupied receptors from antagonist-occupied receptors.
L E, Limbird, S T, MacMillan, D L, Kalinoski   +2 more
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Interaction betweenα2- and β-adrenergic receptors in rat cerebral cortical membranes: clonidine-induced reduction in agonist and antagonist affinity for β-adrenergic receptors

Brain Research, 1991
The interaction between alpha 2- and beta-adrenergic receptors was investigated in rat cerebral cortical membranes. Clonidine inhibition of [3H]dihydroalprenolol ([3H]DHA) binding resulted in biphasic competition curves with a mean Hill coefficient of 0.45.
T, Nakamura, R, Tsujimura, J, Nomura
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GTP regulates binding of agonists to alpha 2-adrenergic receptors in human platelets.

Archives internationales de pharmacodynamie et de therapie, 1982
The potent alpha 2-adrenergic receptor antagonist 3H-yohimbine was used to characterize alpha-adrenergic receptors in human platelet membranes. Binding of 3H-yohimbine was at 25 degrees rapid (t 1/2 = 3 min) readily reversible (t 1/2 = 5.5 min), saturable with 221 +/- 38.9 fmoles bound/mg protein (N = 10) and of high affinity (KD = 1.97 nM). Inhibition
O E, Brodde, A, Hardung, H, Ebel, K D, Bock   +3 more
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