Results 241 to 250 of about 20,695 (270)
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Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2019
The mechanism of the neuroprotective action of α2-adrenergic receptor agonists in a model of oxygen-glucose deprivation (OGD) in vitro was investigated. Using fluorescent microscopy, immunostaining, inhibitor analysis, and real-time PCR analysis, we demonstrated that OGD evokes a biphasic [Ca2+]i increase in all cells.
S. G. Gaidin +5 more
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The mechanism of the neuroprotective action of α2-adrenergic receptor agonists in a model of oxygen-glucose deprivation (OGD) in vitro was investigated. Using fluorescent microscopy, immunostaining, inhibitor analysis, and real-time PCR analysis, we demonstrated that OGD evokes a biphasic [Ca2+]i increase in all cells.
S. G. Gaidin +5 more
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Cross‐dependence to opioid and α 2 ‐adrenergic receptor agonists in NG108‐15 cells
The FASEB Journal, 1988Clonidine, a partial α 2 agonist, has been used empirically to alleviate opiate withdrawal symptoms, but the mechanism of its effects is not completely understood. We studied the interactions of opioid and adrenergic receptor agonists in the NG108‐15 cells, which are a model of opiate ...
S, Lee, C R, Rosenberg, J M, Musacchio
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Brain Research Bulletin, 1989
Systemic (IV) administration of the alpha 2 receptor agonist clonidine is known to stimulate secretion of PRL and growth hormone (GH) suggesting a stimulatory role of the central alpha 2 receptors in the regulation of the two hormones. The present work confirms this notion for GH but indicates that the alpha 2 agonists stimulate PRL release by a ...
J, Jurcovicová, T, Le, L, Krulich
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Systemic (IV) administration of the alpha 2 receptor agonist clonidine is known to stimulate secretion of PRL and growth hormone (GH) suggesting a stimulatory role of the central alpha 2 receptors in the regulation of the two hormones. The present work confirms this notion for GH but indicates that the alpha 2 agonists stimulate PRL release by a ...
J, Jurcovicová, T, Le, L, Krulich
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GTP regulates binding of agonists to alpha 2-adrenergic receptors in human platelets.
Archives internationales de pharmacodynamie et de therapie, 1982The potent alpha 2-adrenergic receptor antagonist 3H-yohimbine was used to characterize alpha-adrenergic receptors in human platelet membranes. Binding of 3H-yohimbine was at 25 degrees rapid (t 1/2 = 3 min) readily reversible (t 1/2 = 5.5 min), saturable with 221 +/- 38.9 fmoles bound/mg protein (N = 10) and of high affinity (KD = 1.97 nM). Inhibition
O E, Brodde +3 more
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Journal of cyclic nucleotide and protein phosphorylation research, 1985
Alpha 2-adrenergic receptors linked to inhibition of adenylate cyclase activity in human platelet membranes can be isolated using DEAE chromatography following solubilization into digitonin-containing buffers. This procedure permits resolution of agonist-occupied receptors from antagonist-occupied receptors.
L E, Limbird +2 more
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Alpha 2-adrenergic receptors linked to inhibition of adenylate cyclase activity in human platelet membranes can be isolated using DEAE chromatography following solubilization into digitonin-containing buffers. This procedure permits resolution of agonist-occupied receptors from antagonist-occupied receptors.
L E, Limbird +2 more
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Increase in human platelet alpha 2-adrenergic receptor affinity for agonist in unstable angina.
The Journal of laboratory and clinical medicine, 1986Spontaneous increase in platelet activity and change in coronary vasomotor tone have been implicated in the pathogenesis of acute myocardial ischemia. To define the mechanism of platelet "hypersensitivity" in acute myocardial ischemia, we examined the status of platelet alpha 2-adrenergic receptors in patients hospitalized with severe unstable angina ...
J, Mehta, P, Mehta, N, Ostrowski
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[Adrenergic receptors and alpha 2 agonists--1) Molecular biological study of adrenoceptors].
Masui. The Japanese journal of anesthesiology, 1997Molecular biological studies have established classification of adrenergic receptors 40 years after Prof Ahlquist first classified them into alpha and beta. They are now classified into 9 subtypes consisting of 400 to 480 amino acids. They belong to a super-family of G-protein coupled receptors.
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[Adrenergic receptor and alpha 2 agonist--2: Structure-function relationship of adrenoceptors].
Masui. The Japanese journal of anesthesiology, 1997Recombinant DNA experiments using chimeric receptors containing portions of alpha 2 and beta 2 adrenoceptors demonstrated structure-function relationships of adrenoceptors. The seventh transmembrane domain determines the subtype ligand binding specificity between alpha 2 and beta 2 adrenoceptors.
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Analgesic and Side Effect Profiles of Novel Alpha-2 Adrenergic Receptor Agonists
The Journal of Pharmacology and Experimental Therapeutics, 2023Cristina D. Peterson +6 more
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Biological psychiatry, 1984
In an attempt to understand the dynamics of noradrenergic function in depression, we evaluated neuroendocrine, biochemical, cardiovascular, and behavioral responses to the acute intravenous administration of the alpha 2-adrenergic agonist, clonidine, in depressed patients and normal controls.
L J, Siever, T W, Uhde
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In an attempt to understand the dynamics of noradrenergic function in depression, we evaluated neuroendocrine, biochemical, cardiovascular, and behavioral responses to the acute intravenous administration of the alpha 2-adrenergic agonist, clonidine, in depressed patients and normal controls.
L J, Siever, T W, Uhde
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