Results 221 to 230 of about 20,695 (270)
alpha 1- and beta 2-adrenergic receptor expression in the Madin-Darby canine kidney epithelial cell line. [PDF]
Journal of Cell Biology, 1983 The Madin-Darby canine kidney (MDCK) cell line, derived from distal tubule/collecting duct, expresses differentiated properties of renal tubule epithelium in culture.
K E Meier, M D Snavely, S L Brown
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Alpha-2 Adrenergic Receptor Agonists are Neuroprotective in Experimental Models of Glaucoma
European Journal of Ophthalmology, 2001Purpose The glaucomas are characterized by chronic progressive ganglion cell loss over many years. A drug with neuroprotective activity should increase the resistance of retinal ganglion cells (RGC) to chronic stress or injury and therefore enhance survival.
L A, Wheeler, E, Woldemussie
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Different Affinities of α2-Agonists for Imidazoline and α2-Adrenergic Receptors
American Journal of Hypertension, 1989It has recently been shown that imidazoline alpha 2-adrenergic agonists, such as clonidine and UK 14,304, selectively bind to both alpha 2- and imidazoline receptors in basolateral membranes from rabbit renal proximal tubule. In order to define the relative affinity of three antihypertensive alpha 2-agonists for the two classes of receptors, we ...
I, Coupry +4 more
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Pharmacological screening of a new alpha-2 adrenergic receptor agonist, mafedine, in zebrafish
Neuroscience Letters, 2019Pharmacological agents acting at alpha-2 adrenergic receptors are widely used in physiology and neuroscience research. Mounting evidence of their potential utility in clinical and experimental psychopharmacology, necessitates new models and novel model organisms for their screening. Here, we characterize behavioral effects of mafedine (6-oxo-1-phenyl-2-
Yuriy I. Sysoev +5 more
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p-[125I]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor.
Molecular Pharmacology, 1990The binding properties of p-[125I]iodoclonidine [( 125I]PIC) to human platelet membranes and the functional characteristics of PIC are reported. [125I]PIC bound rapidly and reversibly to platelet membranes, with a first-order association rate constant (kon) at room temperature of 8.0 +/- 2.7 x 10(6) M-1 sec-1 and a dissociation rate constant (koff) of ...
M A, Gerhardt, S M, Wade, R R, Neubig
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Peripheral nociceptive effects of α2-adrenergic receptor agonists in the rat
Neuroscience, 1995We have previously shown that norepinephrine can produce hyperalgesia via an alpha 2-adrenergic receptor mechanism. The alpha 2-adrenergic receptor agonist clonidine has, however, also been shown to produce peripheral analgesia. In view of the multiple alpha 2-subtypes currently known (i.e.
S G, Khasar +3 more
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Effects of an Alpha-2 Adrenergic Receptor Agonist in Spinal Rats
1988It is now several decades that diverse surgical and pharmacological treatments have been employed to prevent and/or ameliorate the sensory motor deficits which ensue an injury to the spinal cord. The restoration of impaired histological and physiologic parameters by compounds which are membrane stabilizers, antiinflammatory, and antioxidant, and which ...
N. E. Naftchi, R. Lehrer, J. A. Sleis
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Archives des maladies du coeur et des vaisseaux, 1989
Imidazolines have been proposed as highly selective drugs for alpha 2-adrenergic receptors. However, we have recently showed that the imidazoline ligand 3H-RX 781094 (idazoxan) binds to both alpha 2-receptors and imidazoline guanidinium receptive substance (IGRS) in rabbit renal proximal tubule.
V, Lachaud +4 more
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Imidazolines have been proposed as highly selective drugs for alpha 2-adrenergic receptors. However, we have recently showed that the imidazoline ligand 3H-RX 781094 (idazoxan) binds to both alpha 2-receptors and imidazoline guanidinium receptive substance (IGRS) in rabbit renal proximal tubule.
V, Lachaud +4 more
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The Journal of Pharmacology and Experimental Therapeutics, 1982
The alpha-1 and alpha-2 adrenergic effects of cirazoline were evaluated in guinea-pig aorta and field-stimulated guinea-pig ileum, respectively. Cirazoline was found to be a full agonist at alpha-1 receptors having an ED50, dissociation constant (KA) and relative efficacy similar to that of (-)-norepinephrine.
R R, Ruffolo, J E, Waddell
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The alpha-1 and alpha-2 adrenergic effects of cirazoline were evaluated in guinea-pig aorta and field-stimulated guinea-pig ileum, respectively. Cirazoline was found to be a full agonist at alpha-1 receptors having an ED50, dissociation constant (KA) and relative efficacy similar to that of (-)-norepinephrine.
R R, Ruffolo, J E, Waddell
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Biochemistry, 1988
The alpha 2 adrenergic receptor (AR) inhibits adenylate cyclase via an interaction with Ni, a guanine nucleotide binding protein. The early steps involved in the activation of the alpha 2 AR by agonists and the subsequent interaction with Ni are poorly understood.
R R, Neubig, R D, Gantzos, W J, Thomsen
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The alpha 2 adrenergic receptor (AR) inhibits adenylate cyclase via an interaction with Ni, a guanine nucleotide binding protein. The early steps involved in the activation of the alpha 2 AR by agonists and the subsequent interaction with Ni are poorly understood.
R R, Neubig, R D, Gantzos, W J, Thomsen
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