Results 161 to 170 of about 20,601 (250)

The Effect of Dopaminergic Medication on Impulse Control and Compulsive Behaviour: A Translational Perspective. [PDF]

Basic Clin Pharmacol Toxicol
Wolfschlag M, Espa E, Hauer KO, Timpka J, Smith R, Odin P, Cenci MA, Håkansson A.   +7 more
europepmc   +1 more source

Heart‐Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Selective purification of heart‐specific spinal and vagal sensory neurons by retrograde labeling and FACS purification showed enhanced spontaneous, optogenetic, and chemically stimulated Ca2+ activity. Transcriptomic profiling identified distinct ion channel and GPCR signatures in heart‐specific sensory neurons.
T. Akgul Caglar, Y. E. Kazci, Z. B. Durdu, S. Sahoglu Goktas, S. Bay, E. Vatandaslar, M. U. Turhan, G. Ozturk, E. Cagavi   +8 more
wiley   +1 more source

Targeted Interventions in HAM/TSP: Emerging Therapies and Future Directions – A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aim Human T‐Lymphotropic virus type 1 (HTLV‐1) infection can lead to HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), a debilitating chronic neurological disease characterized by progressive lower limb spasticity and autonomic dysfunction.
Meygol Mirzaei Rezaei, Mahdi Khosravi Nia, Kasra Allaei Rouzbahani, Maryam Kazemi, Negar Asghari Hosori, Mehdi Norouzi, Farzaneh Sotoudegan, Narges Eslami, Negar Ariamand, Vahid Shahnavaz, Arash Letafati, Sayed‑Hamidreza Mozhgani   +11 more
wiley   +1 more source

Potential of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in Mitigating Metabolic Side Effects Associated With Clozapine or Olanzapine Therapy: A Literature Review. [PDF]

Cureus
Meftah A, Yoade B, Cowart C, Choi A, Popoola O, Afe O, Efremoff S, Ezema C, Johnson B, Lawrence J, Olupona T.   +10 more
europepmc   +1 more source

Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk

Immunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.
ABSTRACT Background Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction. Objective This review summarizes current evidence on the roles of ATMs in obese adipose tissue and examines how macrophage polarization and metabolic ...
Yuanyuan Li, Jingwei Mao, Yiwen Deng, Xiaobo Ge, Limin Nie, Qun Wang, Ruiqing Wang, Jiarun Zhang, Tianli Lyu, Luopeng Zhao, Lu Liu, Bin Li   +11 more
wiley   +1 more source

The NeuroImmunoEndocrine Circuit of Umami Peptides: A Systems Biology Approach. [PDF]

Nutrients
Hemmati S, Mohagheghzadeh A.
europepmc   +1 more source

The gut microbiome organ

iMeta, Volume 5, Issue 4, August 2026.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source

SENSIT, a Modular Single-Chain Fluorescent Integrator Platform for GPCR Ligands. [PDF]

ACS Chem Biol
Putansu A, Solowiej I, Rivett-Trznadel H, Lakkanasirorat B, Moran L, Kroning KE, Liu J, Li X, Li P, Wang W.   +9 more
europepmc   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

A Novel Small‐Molecule Dual Adiponectin Receptor 1/2 Agonist Induces Myogenesis and Ameliorates Skeletal Muscle Atrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy is a hallmark of ageing and chronic diseases, yet effective pharmacotherapies remain unavailable. Adiponectin signalling through AdipoR1 and AdipoR2 regulates skeletal muscle metabolism, regeneration and oxidative capacity, but the therapeutic use of adiponectin is limited by its large size and complex ...
Shubhrajyoti Das, Pallavi Awasthi, Md. Rameez Moin, Shyamal Pal, Anushka Talukdar, Akhilesh Kumar, Nikhil Nikolas, Shruti Suhas Varode, Shamima Khatoon, Nabanita Das, Sourav Chattopadhyay, Madhav Nilkanth Mugale, Rajdeep Guha, Sabyasachi Sanyal, Atul Goel   +14 more
wiley   +1 more source