Results 61 to 70 of about 41,637 (221)

Could dopamine agonists aid in drug development for anorexia nervosa? [PDF]

, 2014
Anorexia nervosa is a severe psychiatric disorder most commonly starting during the teenage-years and associated with food refusal and low body weight. Typically there is a loss of menses, intense fear of gaining weight, and an often delusional quality ...
Frank, Guido KW
core   +2 more sources

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation [PDF]

, 2010
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior ...
Arvanites, Anthony, Haggarty, Stephen J., Jang, Sumin, Kokel, David, Lam, Kelvin, Peterson, Randall T., Prober, David A., Rihel, Jason, Rubin, Lee L., Schier, Alexander F., Zimmerman, Steven   +10 more
core   +1 more source

Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review

Health Technology Assessment, 2016
Background: Care of critically ill patients in intensive care units (ICUs) often requires potentially invasive or uncomfortable procedures, such as mechanical ventilation (MV). Sedation can alleviate pain and discomfort, provide protection from stressful
Moira Cruickshank, Lorna Henderson, Graeme MacLennan, Cynthia Fraser, Marion Campbell, Bronagh Blackwood, Anthony Gordon, Miriam Brazzelli   +7 more
doaj   +1 more source

Micro-RNA family that modulates fibrosis and uses thereof [PDF]

, 2017
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response
Olson, Eric N., van Rooij, Eva
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The Effect of Dexmedetomidine on the Acute Pain After Cardiothoracic Surgeries: A Systematic Review

Brazilian Journal of Cardiovascular Surgery
Introduction: Acute post-operative pain remains a troublesome complication of cardiothoracic surgeries. Several randomized controlled trials have examined the efficacy of dexmedetomidine as a single or as an adjuvant agent before, during and after ...
Valiollah Habibi, Farshad Hasanzadeh Kiabi, Hassan Sharifi   +2 more
doaj   +1 more source

Alpha-adrenergic receptor agonists in terms of modern views on glaucoma monitoring and treatment [PDF]

РМЖ "Клиническая офтальмология", 2019
The article reviews historical aspects of direct and indirect (by reducing intraocular pressure (IOP)) neuroprotective effect of brimonidine in terms of modern views on glaucoma monitoring and treatment.
V.P. Erichev, S.Yu. Petrov, A.V. Volzhanin, D.M. Safonova, T.V. Yaremenko, S.A. Kazaryan   +5 more
doaj  

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]

, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E, Mahoney, Jacob P, Manglik, Aashish, Sunahara, Roger K, Traynor, John R   +4 more
core  

Current and prospective pharmacological targets in relation to antimigraine action [PDF]

, 2008
Migraine is a recurrent incapacitating neurovascular disorder characterized by unilateral and throbbing headaches associated with photophobia, phonophobia, nausea, and vomiting. Current specific drugs used in the acute treatment of migraine interact with
A Bergerot, A Buchwalder, A Carlsson, A Carlsson, A Hughes, A MaassenVanDenBrink, A MaassenVanDenBrink, A May, A May, A May, A Pindon, A Rouleau, A Srikiatkhachorn, A Sudilovsky, A Tanoue, A Wackenfors, AC Honey, AD Bennett, AD Medhurst, AD Michel, AE Luebke, AH Bom, AH Calhoun, AJ Kaumann, AL Magos, AM Aloisi, AM Carruthers, AM Lands, AM Maagdenberg van den, Antoinette MaassenVanDenBrink, AP Ford, AP Silva, B Forssman, B Gómez-Mancilla, B Pouzet, B Schaerlinger, B Weiss, BB Fredholm, BB Hoffman, BJ Francken, BK Kobilka, BK Rasmussen, BW Somerville, BW Somerville, C Hofmann, C Hohoff, C Lampl, C Tzourio, CA Salvatore, Carlos M. Villalón, CG Dahlöf, CM Villalón, CM Villalón, CM Villalón, CM Villalón, CN Sang, CY Yu, D Centurión, D Hoyer, D Hoyer, D Sarsero, DA Curran, David Centurión, DB Bylund, DB Bylund, DB Bylund, DB Bylund, DB Bylund, DD Mitsikostas, DD Mitsikostas, DE Dluzen, DJ Goldstein, DJ Goldstein, DJ Goldstein, DL Jackson, DM Pérez, DR Poyner, DR Thomas, DR Thomas, DS Millson, DW Dodick, E Del Bene, E Enmark, E Fabbretti, E Fusayasu, E Tronvik, EA Barnard, EA MacGregor, EA MacGregor, EA MacGregor, EA MacGregor, EM Cassidy, EW Willems, EW Willems, EW Willems, EW Willems, F Facchinetti, F Facchinetti, F Marceau, F Martínez, FG Freitag, FM Cutrer, FM Cutrer, FM Cutrer, G Attali, G Burnstock, G D’Andrea, G Trapani Di, GA Lambert, GA Michelotti, GL Stiles, GM Terwindt, GW Price, GW Smith, H Doods, H Heyck, H Kaube, H Kowa, H Schrader, HC Diener, HM Vargas, HO Kalkman, HS Blaxall, I Jansen-Olesen, I Mody, IH Page, IT Forbes, J Galitzky, J Honkaniemi, J Olesen, J Olesen, JA Charles, JA Terrón, JB Becker, JC Jen, JC Shih, JD Carroll, JD Classey, JE Palmer, JJ Fernández-Ruíz, JL Brandes, JM Brundege, JM Cruickshank, JM Orshal, JP Dreier, JP Hieble, JP Hieble, JR Arch, JR Clements, JR Docherty, JR Fozard, JW Lomasney, JW Regan, K Kapoor, K Schmuck, K Zimmermann, KA Krobert, KA Petersen, KA Petersen, Kayi Y. Chan, KI Roon, KJ Powell, KL Hoskin, KMA Welch, KP Lesch, KR Oliver, KW Johnson, L Edvinsson, L Edvinsson, L Hein, LA Phebus, LE Limbird, LH Lassen, LH Lassen, LH Lassen, LJ Smith, LL Ven van de, LM McLatchie, M Anthony, M Anthony, M Boccuni, M Cyr, M Farkkila, M Gasparo De, M Hasselblatt, M Iovino, M Kallela, M Mochi, M Oshita, M Peeters, M Quartu, M Spedding, M Yanagisawa, MA Moskowitz, MA Moskowitz, MD Ferrari, MD Ferrari, ME Bigal, ME Erdal, ME Moreau, MG Garry, MG Hanna, MJ Kelly, ML Hernández, MM Rapport, MT Piascik, NG Bowery, NJ Colson, NJ Colson, NJ Giffin, NM Barnes, NM Ramadan, NM Ramadan, NM Ramadan, NT Mathew, O Blin, P Barbanti, P Barbanti, P Geppetti, P Kastner, P Roffey, P Sarchielli, P Sarchielli, P Tfelt-Hansen, P Tfelt-Hansen, P Vries De, P Vries De, PD Drummond, PD Drummond, PJ Goadsby, PJ Goadsby, PJ Goadsby, PJ Goadsby, PJ Goadsby, PJ Goadsby, PJ Goadsby, PJ Goadsby, PL Durham, PP Lakhlani, PR Saxena, PR Saxena, PR Saxena, PR Saxena, Pramod R. Saxena, PT Hurley, QP Ma, R Burstein, R Cerbo, R Hering-Hanit, R Lodi, R Quirion, R Rabkin, R Uddman, R Würz, RA Bond, RA Ophoff, RB Lipton, RB McCall, RE Widdop, RJ Storer, RJ Storer, RJ Storer, RL Weinshank, RO Millán-Guerrero, RO Millán-Guerrero, RP Ahlquist, RW Kimball, RWM Broek van den, S Akerman, S Akerman, S Akerman, S Akerman, S Akerman, S Cotecchia, S Ghelardoni, S Gupta, S Gupta, S Gupta, S Maude, S Mehrotra, S Mehrotra, S Nag, S Paterna, S Shepheard, S Stellar, Saurabh Gupta, SD Brain, SD Silberstein, SD Silberstein, SD Silberstein, SG Hamilton, SJ Hill, SJ Peroutka, SJ Peroutka, SJ Peroutka, SJ Peroutka, SJ Peroutka, SJ Peroutka, SJ Tallaksen-Greene, SJ Tepper, SM Lanier, SP Alexander, SP Cook, SP Cook, ST Lee, Suneet Mehrotra, T Attina, T Ishida, T Ishida, T Matsubara, T Takenaka, TJ Murphy, TM Buchanan, TW Ho, U Arulmani, U Arulmani, U Arulmani, V Erspamer, V Erspamer, V Johannsson, V Limmroth, V Shaygannejad, V Simonneaux, VT Martin, W Chai, WF Stewart, WI Bender, WL Hasler, WM Herrmann, WS Lee, Y Dumont, Y Sahara, Y Zhang, YT Lau, Z Cohen, Z Zhang   +335 more
core   +9 more sources

Dexmedetomidine as an Adjuvant in Peripheral Nerve Block

Drug Design, Development and Therapy, 2023
Zheping Chen, Zhenzhen Liu, Chang Feng, Yanwu Jin, Xin Zhao Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People’s Republic of ChinaCorrespondence: Yanwu Jin; Xin Zhao, Email ...
Chen Z, Liu Z, Feng C, Jin Y, Zhao X
doaj  

Molecular biology of amitraz resistance in cattle ticks of the genus Rhipicephalus [PDF]

, 2018
Amitraz is an important product for the control of cattle ticks around the world. In comparison with other products for the control of ticks, it is quite affordable and it has a rapid knock-down effect.
Berry, Christina M., Corley, Sean W., Jonsson, Nicholas N., Klafke, Guilherme, Koh-Tan, H.H. Caline, Tidwell, Jason   +5 more
core   +1 more source