Results 201 to 210 of about 104,693 (298)

Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis.

Pharmacology and Therapeutics, 2009
C. Fairbanks, L. Stone, G. Wilcox
semanticscholar   +1 more source

The Allosteric Mechanism of G‐Protein‐Coupled Receptors is Induced Fit, Not Conformational Selection

BioEssays, Volume 47, Issue 12, December 2025.
Allosteric signaling of G‐protein‐coupled receptors (GPCRs) involves a population shift from inactive to active receptor conformations upon binding of ligand agonists. Kinetic and structural data indicate that this population shift is induced by ligand binding to inactive receptor conformations prior to the conformational change from inactive to active.
Kazem Asadollahi, Paul R. Gooley, Thomas R. Weikl   +2 more
wiley   +1 more source

β₂-Adrenergic Receptor Agonists in Diabetic Kidney Disease: Exploring a New Frontier. [PDF]

Biochem Res Int
Hegde S, Chogtu B, Magazine R, Magazine R, Prabhu R.   +4 more
europepmc   +1 more source

Effects of alpha-adrenoceptor agonists and antagonists on adrenergic neurotransmitter overflow from dog isolated saphenous veins [proceedings].

, 1980
G.M. Drew, Andrew T. Sullivan
openalex   +1 more source

Mechanism of amylase release by .ALPHA.-adrenergic and cholinergic agonists in rat parotid gland.

, 1986
Eriko NEZU
openalex   +2 more sources

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1463-1476, December 2025.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Bisphenol A‐Induced Vascular Endothelial Dysfunction: Protective Effects of Nigella sativa Oil and Thymoquinone

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
BPA exposure in rats and HUVECs impaired aortic contractility, increased lipid peroxidation, ROS, NO, VCAM‑1, and p‑eNOS, and blunted relaxant responses. Co‑treatment with NSO or TQ restored KCl/PE‑induced contractions, enhanced ACh‑ and SNP‑mediated vasorelaxation, and lowered oxidative/nitrosative stress and adhesion molecule expression.
Masoumeh Fadishei, Mahdieh Sadat Mohsenzadeh, Bibi Marjan Razavi, Mohsen Imenshahidi, Seyed Ahmad Mohajeri, Mahboubeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh   +6 more
wiley   +1 more source

Effects of the alpha 2‐adrenergic agonist clonidine and its antagonist idazoxan on the fetal lamb.

, 1986
O. S. Bamford, G. S. Dawes, Rachel R. Denny, Rob Ward   +3 more
openalex   +2 more sources

Alpha-2 agonists for refractory neurological symptoms in pediatric palliative care: a scoping review. [PDF]

Front Pediatr
Salerno A, Baratiri F, La Piana C, Bincoletto A, Benini F, Zanin A.   +5 more
europepmc   +1 more source

The nitric oxide-cGMP system of the locus coeruleus and the hypnotic action of alpha-2 adrenergic agonists

, 1999
Yvonne Vulliemoz, Robert A. Whittington, László Virág   +2 more
openalex   +1 more source