Results 91 to 100 of about 17,930 (241)

Effects of Alpha‐ and Beta‐Adrenergic Agonists and Antagonists on Growth Hormone Secretion in Man [PDF]

, 1990
Ezio Ghigo, J. Bellone, Emanuela Arvat, Enrico Mazza, S. G. Cellat, Frăncesca Brambilla, Eugenio E. Müller, F. Camanni   +7 more
openalex   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Acute Urinary Morbidity Following Stereotactic Body Radiation Therapy for Prostate Cancer with Prophylactic Alpha-Adrenergic Antagonist and Urethral Dose Reduction [PDF]

, 2016
Michael Repka, Shan Guleria, Robyn A. Cyr, Thomas Yung, Harsha Koneru, Leonard N. Chen, Siyuan Lei, Brian T. Collins, Pranay Krishnan, Simeng Suy, Anatoly Dritschilo, John H. Lynch, Sean P. Collins   +12 more
openalex   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Alpha-1 adrenergic antagonists use increases the risk of sleep apnea: implications for understanding the role of prazosin in posttraumatic stress syndrome [PDF]

, 2020
W. Vaughn McCall
openalex   +1 more source

3,4‐Methylenedioxymethamphetamine (MDMA) does not induce robust psychomotor activation and 50‐kHz ultrasonic vocalisations in tryptophan hydroxylase 2 (Tph2)‐deficient rats lacking serotonin in the central nervous system

British Journal of Pharmacology, EarlyView.
Background and Purpose 3,4‐Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, is a psychostimulant with entactogenic properties and known to induce arousal and euphoria. As an amphetamine derivate, MDMA acts on the monoamine systems in the brain and stimulates release of dopamine (DA), noradrenaline (NA) and serotonin (5‐HT), yet their ...
Tianhua Wang, Rainer K. W. Schwarting, Markus Wöhr   +2 more
wiley   +1 more source

1727: Effects of Alpha-1 Adrenergic Receptor Subtype· Selective Antagonists on Lower Urinary Tract Function in RATS with Bladder Outlet Obstruction [PDF]

, 2004
Baojun Gu, Jerome P. Reiter, Debra A. Schwinn, Michael P. Smith, Cees Korstanje, Karl B. Thor, Paul C. Dolber   +6 more
openalex   +1 more source

USE OF ALPHA-ADRENERGIC ANTAGONISTS FOR LOWER URINARY TRACT SYMPTOMS IS NOT ASSOCIATED WITH WORSENING COGNITIVE FUNCTION.

, 2023
Fernanda Gabrigna Berto, J. Andrew McClure, Jeffrey Campbell, Blayne Welk   +3 more
openalex   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, EarlyView.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source