Results 181 to 190 of about 36,879 (305)
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
Cell Proliferation, EarlyView.HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang +4 more
wiley +1 more source
European Journal of Clinical Investigation, EarlyView.This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone +28 more
wiley +1 more source
Effects of the alpha 2‐adrenergic agonist clonidine and its antagonist idazoxan on the fetal lamb.
, 1986 O. S. Bamford +3 more
openalex +2 more sources
The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments [PDF]
, 2023 Thijs Van de Vyver +6 more
openalex +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Sedation in horses is typically achieved using alpha‐2 adrenoceptor agonists, although their use is associated with multiple side effects. A peripheral alpha‐2 adrenoceptor antagonist, vatinoxan, can alleviate many of these. Objectives To evaluate the effects of vatinoxan infusion on gastrointestinal motility, sedation, and ...
Bartlomiej Obrochta +7 more
wiley +1 more source
Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera
The FEBS Journal, EarlyView.Here, we report KTX207, a previously undescribed cereblon‐based PDE4 PROTAC that can specifically target PDE4D shortform for degradation. We showed that KTX207 could improve selectivity, potency and enable a long‐lasting effect when used at a sub‐nanomolar concentration.
Yuan Yan Sin +16 more
wiley +1 more source
Analogs of phosphatidylcholine: alpha-adrenergic antagonists from the renal medulla. [PDF]
, 1981 Keith A. Smith +3 more
openalex +1 more source
Journal of the European Academy of Dermatology and Venereology, EarlyView.Multiple inflammatory, infectious and autoimmune dermato‐venereological conditions are associated with erectile dysfunction (ED) due to underlying intricate vasculogenic, neurogenic, endocrine and psychogenic mechanisms. It is recommended that practitioners screen dermatology patients for ED and associated comorbidities, provide personalized lifestyle ...
Andrei Tanasov, George‐Sorin Tiplica
wiley +1 more source
Mind the GAPS: Glia associated with psychological stress
Journal of Neuroendocrinology, EarlyView.Abstract Glial cells are an integral component of the nervous system, performing crucial functions that extend beyond structural support, including modulation of the immune system, tissue repair, and maintaining tissue homeostasis. Recent studies have highlighted the importance of glial cells as key mediators of stress responses across different organs.
Niklas Blank +4 more
wiley +1 more source