Meta-analysis of the efficacy and adverse drug reactions of adrenergic alpha-antagonists in treating children with ureteral calculi. [PDF]
Front Pediatr, 2023 This meta-analysis investigated the efficacy and adverse drug reactions (ADRs) of three different adrenergic alpha-antagonists during the treatment of pediatric ureteral stones.
Sun K, Zhang P, Sun Y, Wang Q, Xia Q.
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Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection [PDF]
eLife, 2021 In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death.
Allison Koenecke +24 more
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Efficacy and safety of adrenergic alpha-1 receptor antagonists in older adults: a systematic review and meta-analysis supporting the development of recommendations to reduce potentially inappropriate prescribing [PDF]
BMC Geriatrics, 2022 Background Adrenergic alpha-1 receptor antagonists (alpha-1 antagonists) are frequently used medications in the management of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) and in the management of therapy-resistant ...
Felix Mansbart +3 more
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Do adrenergic alpha-antagonists increase the risk of poor cardiovascular outcomes? A systematic review and meta-analysis. [PDF]
ESC Heart Fail, 2022 Due to concerns regarding neurohormonal activation and fluid retention, adrenergic alpha‐1 receptor antagonists (A1Bs) are generally avoided in the setting of heart disease, namely, symptomatic heart failure (HF) with reduced ejection fraction (HFrEF ...
Sousa JP +3 more
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The effects of alpha 2-adrenergic and serotonergic receptor antagonists on cyclic blood flow alterations in stenosed canine coronary arteries. [PDF]
Circulation Research, 1984 Platelets possess alpha 2-adrenergic and serotonergic (5-hydroxytryptamine) receptors which are thought to mediate the in vitro proaggregatory effects of epinephrine and serotonin, respectively.
Larry R. Bush +8 more
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Alpha-adrenergic antagonists and iris dynamics: Challenges and solutions in cataract surgery. [PDF]
BMC OphthalmolBackground Alpha-1 adrenergic receptor antagonists (α1-ARAs) are frequently used in treatment of Hypertension and symptomatic benign prostatic hypertrophy (BPH).
Kaushik J +5 more
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Rat cardiac muscle single cell automaticity responses to alpha- and beta-adrenergic agonists and antagonists. [PDF]
Circulation Research, 1982 Isolated cardiac muscle cells from neonatal rat ventricular myocardium have both alpha- and beta-adrenergic, positive chronotropic responses, with sensitivity to applied adrenergic agents more than 100 times greater than the intact neonatal heart.
Kent Hermsmeyer +3 more
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Analogs of phosphatidylcholine: alpha-adrenergic antagonists from the renal medulla. [PDF]
HYPERTENSION, 1981 Antihypertensive polar renomedullary lipid (APRL), a conglomerate of 1-0-alkyl-2-acetoyl-glycero-3-phosphocholine analogs, ws tested in 4- to 6-week-old spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats using microcirculatory ...
Keith A. Smith +3 more
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Frontiers in Medicine, 2021 Effective therapies for coronavirus disease 2019 (COVID-19) are urgently needed, and pre-clinical data suggest alpha-1 adrenergic receptor antagonists (α1-AR antagonists) may be effective in reducing mortality related to hyperinflammation independent of ...
Liam Rose +17 more
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The use of alpha-adrenergic antagonists in pediatric nephrolithiasis: a systematic review. [PDF]
Front PediatrObjectiveTo evaluate existing clinical evidence for the efficacy of alpha blockers in the management of pediatric stone disease.MethodsWe conducted a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA ...
Haddad F, Farhat WA, Cannon S.
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